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Microstress-induced reaction method and preparation method of pointer nuclear-shell microparticles using same

A micro-stress and reaction technology, applied in the field of micro-machining, can solve the problems of reducing the dimensional accuracy of the product structure, high production cost and difficulty, increasing operation time and difficulty, etc., achieving huge application potential, strong directivity, and traceability strong effect

Active Publication Date: 2014-08-13
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the production cost and difficulty of this kind of microfluidic chip are relatively high, and it is necessary to purchase a photolithography machine, a corresponding photolithography mask, a PDMS substrate, etc.; The potential application in the field is limited; in addition, this method controls the shape change of the particles through the drying method, which increases the operation time and difficulty, and reduces the dimensional accuracy of the product structure

Method used

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  • Microstress-induced reaction method and preparation method of pointer nuclear-shell microparticles using same
  • Microstress-induced reaction method and preparation method of pointer nuclear-shell microparticles using same
  • Microstress-induced reaction method and preparation method of pointer nuclear-shell microparticles using same

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preparation example Construction

[0050] Preparation method of pointer core-shell microparticles

[0051] In a second aspect of the present invention, a method for preparing pointer core-shell microparticles is provided, the method comprising the following steps:

[0052] (1) Droplet preparation: Utilizing the mechanism of droplet manipulation, through the shrinkage of the geometric size of the microchannel in the microfluidic device and the mutual shearing and sticking effects of the internal phase, the intermediate phase, and the external phase fluid, a microfluidic device is formed. Water-in-oil-in-water (W / O / W) composite emulsion droplets containing an inner droplet;

[0053] (2) Emulsion collection: the emulsion droplets obtained in step (1) are collected in a container containing the receiving phase; and

[0054] (3) Droplet polymerization reaction and formation of pointer microparticles: the emulsion obtained in step (2) is placed under ultraviolet light, and the outer droplet part undergoes polymeri...

Embodiment 1

[0087] Preparation and parameter regulation of pointer microparticles:

[0088] The particle preparation process is as follows figure 2 As shown, the microfluidic device used is as image 3 shown. The inner phase solution is an aqueous solution of surfactant 1% Pluronic F-127 (Sigma-Aldrich, U.S.), 5% glycerol and 1% carbon ink, and the middle phase is 5% PGPR90 (polyglyceryl ricinoleate). , Denmark Danisco company), 1% HMPP (2-hydroxy-2-methyl-1-phenyl-1-propanone, EGDMA (ethylene glycol dimethacrylate, Sigma-Aldrich, USA) company) solution, the internal phase solution is an aqueous solution that is dissolved with surfactant 1% Pluronic F-127 and 5% glycerin, and the receiving phase is dissolved with surfactant 1% Pluronic F-127, 5% glycerin and 1mol / L chloride An aqueous solution of calcium. The internal phase, intermediate phase, and external phase were passed into the microfluidic device at flow rates of 50 μL / h, 800 μL / h, and 4000 μL / h, respectively, and the receivin...

Embodiment 2

[0090] Preparation and Characterization of Magnetically Responsive Functionalized Pointer Microparticles:

[0091] The particle preparation process is as follows figure 2 As shown, the microfluidic device used is as image 3 shown. The internal phase solution is dissolved in surfactant 1% Pluronic F-127, 5% glycerin, 1% carbon ink and 50% Fe 3 o 4 The aqueous solution of magnetic nanoparticles, the middle phase is EGDMA solution dissolved with PGPR90 and HMPP, the inner phase solution is an aqueous solution dissolved with surfactant Pluronic F-127 and glycerin, and the receiving phase is dissolved with surfactant 1% Pluronic F-127 , 5% glycerin and 1mol / L calcium chloride aqueous solution. The internal phase, intermediate phase, and external phase were passed into the microfluidic device at flow rates of 100 μL / h, 1000 μL / h, and 6000 μL / h, respectively, and the receiving phase was poured into a petri dish. The droplet formation process in the microfluidic device is as fo...

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Abstract

The invention relates to a microstress-induced reaction method and a preparation method of pointer nuclear-shell microparticles using the same, and provides a microstress-induced reaction method, which comprises the following steps: inducing the stress applied to a structure in a microspace so as to change the morphology of the structure, wherein the structure in the microspace is coated by a completely sealed medium so as to separate from an outside space; the concentration of a liquid at the outer side of the medium is higher than that of the liquid at the inner side. The invention further provides a preparation method of pointer nuclear-shell microparticles.

Description

technical field [0001] The invention belongs to the field of micromachining, and relates to a micro-stress-induced reaction and a method for preparing non-spherical core-shell microparticles. Specifically, the invention relates to a micro-stress-induced reaction, and a method based on microfluidic technology and utilizing The microstress-induced reaction is a method for preparing core-shell microparticles with a special pointer structure. Background technique [0002] Microstructure refers to various heterogeneous structures in the crystal structure at the micron or nanometer scale, which has important application significance in the fields of microelectromechanical systems, microreactors, and biomedicine. The research on its deformation laws and morphology control methods is the condition for determining whether to develop complex functional microstructures. [0003] At present, the morphology control of the microstructure is mainly realized by physical or chemical methods...

Claims

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Application Information

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IPC IPC(8): B81C1/00
Inventor 邱阳汪华林王飞白志山张艳红杨强
Owner EAST CHINA UNIV OF SCI & TECH
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