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Preparation method of cyclodextrin-modified magnetic nano-adsorbent and its application in hemodialysis adsorption system

A magnetic nanometer and hemodialysis technology, applied in the field of biomedical materials, can solve the problems of high cost of separation and purification, and achieve the effects of convenient separation and purification, improved adsorption capacity, and strong magnetism

Active Publication Date: 2016-01-13
DALIAN UNIV OF TECH
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Problems solved by technology

[0005] The purpose and task of the present invention is to overcome the high separation and purification cost of the existing water-soluble adsorbent for hemodialysis to absorb and remove bilirubin, and to provide a kind of bilirubin with excellent adsorption performance, easy to separate and recover, and in water A method for preparing an adsorbent with high dispersion in the phase, especially the cyclodextrin-modified magnetic nano-adsorbent Fe of the present invention 3 o 4 -Preparation of β-CD and technical solutions for its application in hyperbilirubinemia hemodialysis adsorption system

Method used

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  • Preparation method of cyclodextrin-modified magnetic nano-adsorbent and its application in hemodialysis adsorption system
  • Preparation method of cyclodextrin-modified magnetic nano-adsorbent and its application in hemodialysis adsorption system
  • Preparation method of cyclodextrin-modified magnetic nano-adsorbent and its application in hemodialysis adsorption system

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Embodiment

[0025] 1. Preparation of magnetic nanoadsorbent based on cyclodextrin modification

[0026] ⑴ Preparation of Fe with better dispersibility and magnetic properties 3 o 4 -TSC magnetic nanoparticles

[0027] Weigh FeCl separately 3 ·6H 2 O1.3515g and FeCl 2 4H 2 O0.5681g, in N 2 Under the protection of the configuration Fe 3+ and Fe 2+ Mixed solution (precursor iron salt solution) 20ml. Weigh 1.4705g of sodium citrate dihydrate and dissolve it in 50ml of deionized water. Add 5ml of concentrated ammonia water into a 50ml three-neck flask, dilute to 30ml with deionized water, pass through N 2 . in N 2 Under the protection of the peristaltic pump, the precursor iron salt is pumped into the three-necked flask, the pumping time is controlled to be 270s and the rotation speed of the agitator is 1400rpm, the aging temperature is 25°C, the reaction is 10min, magnetic separation, and the upper layer of lye is poured out. Add 50ml of sodium citrate solution, and react for 2h ...

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Abstract

The invention discloses a preparation method of a cyclodextrin modified magnetic nano adsorbent and the application of the cyclodextrin modified magnetic nano adsorbent in a hemodialysis adsorption system, belonging to the field of biomedical material. The method takes FeCl3.6H2O, FeCl2.4H2O and ammonia water as raw materials, trisodium citrate (TSC) as a dispersing agent, polyethylene imine (PEI) as a modification substrate and beta-cyclodextrin (CD) as an adsorption functional group, and comprises the steps of synthesizing magnetic nanoparticles which are modified by the TSC and are small in particle sizes, good in dispersion and strong in magnetism by a reverse chemical coprecipitation method; enabling a PEI modified layer to be adsorbed onto the surface of Fe3O4-TSC by electrostatic interaction; grafting the beta-CD by a Schiff base reaction to obtain the cyclodextrin modified magnetic nano adsorbent-Fe3O4-beta-CD. The adsorbent has magnetism, so that the separation and purification process is more convenient and rapider, and the separation and purification cost is low; the cyclodextrin modified magnetic nano adsorbent has better adsorption capacity for hydrophobic toxin in the hemodialysis adsorption system.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a preparation method of a cyclodextrin-modified magnetic nanometer adsorbent and its application in a hemodialysis adsorption system. Background technique [0002] Bilirubin is a normal metabolite of hemoglobin in aging red blood cells. Due to liver damage and metabolic disorders, its concentration in the body will increase abnormally and become an endogenous toxin, causing irreversible damage to the brain and nervous system. And further damage the liver and other organs. At present, the blood purification techniques used to remove such hydrophobic toxins mainly include: hemofiltration, hemoperfusion, etc., and adsorption dialysis combined detoxification systems, such as Molecular Adsorbent Recirculating System (MARS). The conventional treatment method used in the early days was hemoperfusion, and the key to determine its effect was bilirubin adsorbents, including activated c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/14
Inventor 贾凌云褚四敏韩璐璐任军徐丽谢健
Owner DALIAN UNIV OF TECH
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