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Method for preparing drug sustained release nanofibers

A nanofiber and drug technology, applied in fiber processing, pharmaceutical formulations, fiber chemical characteristics, etc., can solve the problems of inability to meet the needs of drug efficacy, reduce the effect of porous structure, and large carrier size, so as to improve the efficiency of drug use and save time. and material cost, low cost effect

Inactive Publication Date: 2014-08-06
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is complicated to prepare, the size of the carrier is large, and there are still some problems in the fine control of the drug, which may reduce the effect of the porous structure on drug release.
At the same time, there is only a single-stage release process, and the release speed is faster than that of coaxial electrospun double-layer nanofibers, which cannot meet the needs of some long-acting drugs.

Method used

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  • Method for preparing drug sustained release nanofibers
  • Method for preparing drug sustained release nanofibers
  • Method for preparing drug sustained release nanofibers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Prepare polylactic-co-glycolic acid (PLGA, 50 / 50, MW40000Da) microspheres with a diameter of about 20 nm loaded with heparin by using the existing emulsification and solidification method, and place it in 10 ml of dichloromethane, Stirring and oscillating to mix evenly to prepare the core layer spinning solution;

[0036](2) Dissolve 1.0g of PGA (intrinsic viscosity: 1.4-1.8dL / g, melt index at 190°C: 0.4-0.7g / min) in 20ml of dichloromethane solvent, stir and oscillate evenly, and make a cortical spinning solution;

[0037] (3) Put the cortex spinning liquid and the core layer spinning liquid into the cortex liquid storage tank 2 and the core layer liquid storage tank 1 respectively, the flow rate of the cortex spinning liquid is 1.0mL / h, and the spinneret aperture is 1.2mm; The flow rate of the core layer spinning solution is 0.6mL / h, the diameter of the spinneret is 0.45mm; the applied voltage is 17kV, the receiving distance is 12cm, and electrospinning is carried ...

Embodiment 2

[0040] (1) Using the existing emulsification-solvent evaporation method to prepare polycaprolactone-polyethylene glycol-polycaprolactone triblock copolymer (PCL-PEG-PCL) nanoparticles with a diameter of about 20 nm loaded with curcumin Microspheres are placed in 10ml of aqueous solution solvent, stirred and oscillated to mix evenly to obtain the core layer spinning solution;

[0041] (2) 0.6g poly-L-lactic acid (PLLA) was dissolved in 10ml chloroform solvent, after stirring and oscillating evenly, a cortical spinning solution was made;

[0042] (3) Put the cortex spinning solution and the core layer spinning solution into the cortex liquid storage tank 2 and the core layer liquid storage tank 1 respectively, the flow rate of the cortex spinning solution is 1.0mL / h, and the diameter of the spinneret is 1.0mm; The flow rate of the core layer spinning solution is 0.4mL / h, the diameter of the spinneret is 0.9mm; the applied voltage is 18kV, the receiving distance is 12cm, and the ...

Embodiment 3

[0045] (1) Using the existing solvent evaporation method to prepare polylactic acid (PLA) microspheres with a diameter of about 36nm loaded with doxorubicin, disperse 3mg of the microspheres in 5ml of aqueous solution;

[0046] (2) 1.0g PLGA is dissolved in 10ml dichloromethane solvent, after stirring and oscillating evenly, make cortex spinning solution;

[0047] (3) Put the cortex spinning solution and the core layer spinning solution into the cortex storage tank 2 and the core layer storage tank 1 respectively, the flow rate of the cortex spinning solution is 1.2mL / h, and the diameter of the spinneret is 1.2mm; The flow rate of the core layer spinning solution is 0.5mL / h, the diameter of the spinneret is 0.8mm; the applied voltage is 18kV, the receiving distance is 15cm, and spinning is carried out. During the spinning process, the volatile solvent in the cortex spinning solution volatilizes to form a through hole holes, get as figure 2 The shown drug slow-release nanofib...

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Abstract

The invention provides a method for preparing drug sustained release nanofibers. The method is characterized by including the specific steps that (1) drug-carried micro-spheres are arranged in an organic solvent to be evenly stirred and vibrated to obtain core layer spinning solutions; (2) degradable solutes and volatile solvents are evenly mixed to prepare surface-layer spinning solutions; (3) the surface-layer spinning solutions and the core layer spinning solutions are injected into a surface-layer liquid storage tank and a core layer liquid storage tank of a coaxial spinning jet respectively, coaxial electrostatic spinning is carried out at the room temperature, and the volatile solvents in the surface-layer spinning solutions volatilize to form through holes in the spinning process to obtain the drug sustained release nanofibers with the porous surface layer and the drug-carried micro-sphere wrapped core layer. By means of the method, the obvious multi-stage drug release system is achieved, and the drug-carried micro-spheres are released in the core layer firstly to enter a hole channel in the surface layer and finally enter damaged target components of the nanofibers to give play to drug effects. The method is simple in operation and gentle in reaction condition. A drug sustained release curve is well controlled, and the drug using efficiency is improved.

Description

technical field [0001] The invention relates to a method for preparing sustained-release drug nanofibers for in vivo use, in particular to a method for preparing a multi-scale drug sustained-release system by coaxial electrospinning. Background technique [0002] At present, the traditional drug release system can be divided into the following three forms according to the different drug release methods and release mechanisms: the accumulative drug release system in which the drug is physically embedded in the polymer film; A homogeneous drug controlled release system mixed in a polymer matrix; a polymer drug controlled release system that combines drugs and polymers with chemical bonds. However, in the early stage of traditional drug administration, the drug concentration is very high, which easily exceeds the patient's tolerance dose, causing toxic and side effects; at the same time, the drug can only be kept in the body for a short time, and the drug concentration is low i...

Claims

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Application Information

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IPC IPC(8): D01D13/00D01D5/34D01D1/02D01F8/14D01F8/00A61K9/50A61K47/34
Inventor 王富军赵帆王璐李超婧葛鹏毛迎郭蕴仪刘婕妤
Owner DONGHUA UNIV
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