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Targeted drug release intervened medical appliance and preparation method thereof

A technology for medical devices and drugs, applied in the field of medical devices, can solve the problems affecting the drug treatment effect of the device and low surface bonding strength, and achieve the effects of good drug treatment effect, high bonding strength, and ensuring the drug dosage range.

Active Publication Date: 2014-07-30
上海赢生医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a targeted drug release interventional medical device and its preparation method, which solves the problem that the drug coating and the surface of the interventional medical device generally have low bonding strength under the current technology, thereby affecting the therapeutic effect of the device.

Method used

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  • Targeted drug release intervened medical appliance and preparation method thereof
  • Targeted drug release intervened medical appliance and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: A targeted drug release interventional medical device and its preparation method

[0034] The interventional medical device used is a coronary balloon dilatation catheter. Dissolve 100mg of paclitaxel, 30mg of polylactic acid, and 5mg of polymethyl methacrylate in 2ml of acetone, formic acid and vitamin E solution (volume ratio: acetone: formic acid: vitamin E=8:1:1), ultrasonic After 10 minutes, a uniformly dispersed drug coating stock solution was obtained. Spray the above solution on the surface of the balloon with a size specification of 3.0×20mm to make the drug loading amount reach 3μg / mm 2 left and right, dried, folded, and the drug balloon is obtained, with figure 1 The SEM picture of the surface of the drug coating before folding, we can see from the picture that the surface of the balloon is smooth, without cracks, and without debris. figure 2This is the SEM picture of the surface of the drug coating after folding. From the picture, we can see t...

Embodiment 2

[0035] Example 2: A targeted drug release interventional medical device and its preparation method

[0036] The interventional medical device used is a balloon dilatation catheter for peripheral blood vessels. Dissolve 200mg of paclitaxel, 50mg of chitin, and 18mg of polybutylmethacrylate in 10ml of a solution of ethanol, acetic acid, and vitamin E (volume ratio: ethanol: acetic acid: vitamin E=7:2:1), and ultrasonically After 10 minutes, a uniformly dispersed drug coating stock solution was formed. Dip-coat the above solution on the surface of the balloon with a size specification of 4.0x100mm to make the drug loading amount reach 2μg / mm 2 left and right, dried, folded, and the drug balloon is obtained.

Embodiment 3

[0037] Example 3: A targeted drug release interventional medical device and its preparation method

[0038] The interventional medical device used is a urethral expansion stent. Dissolve 400mg of plicamycin, 700mg of iodixanol, and 400mg of polyisobutylmethacrylate in 2ml of a solution of glycerol, acetone, and butylhydroxyanisole (volume ratio: glycerol: acetone : Butylated hydroxyanisole=3:6:1), ultrasonic 10min to form a uniformly dispersed drug coating stock solution. The above solution was absorbed and coated on the surface of the biliary dilatation stent, so that the drug loading amount reached 9 μg / mm 2 left and right, and dried to obtain the drug sustained-release urethral expansion stent.

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Abstract

The invention provides a targeted drug release intervened medical appliance and a preparation method thereof. The medical appliance is characterized by comprising an intervening medical appliance and a sustained-release drug coating, wherein the sustained-release drug coating is applied to the surface of the intervening medical appliance. The preparation method comprises a step of applying drugs to the intervening medical appliance to form the targeted drug release intervened medical appliance, wherein the sustained-release drug coating consists of a medicinal material, a medicinal carrier material, antioxidant and adhesive, and the drug application to the intervening medical appliance sequentially comprises the following steps: (1) preparing the sustained-release drug coating; (2) applying the sustained-release drug coating; (3) drying. According to the targeted drug release intervened medical appliance, the binding strength between the sustained-release drug coating and the surface of the intervening medical appliance is high, the medicinal material is prevented from being lost in the subsequent processing process, and the targeted drug release intervened medical appliance has a good drug treatment effect.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a device for intracavity therapy with an integrated structural design capable of targeted and fixed-point administration and slow release of therapeutic drugs in targeted lesion areas and a preparation method thereof. Background technique [0002] With the wide application of drug sustained-release stent systems and the continuous development of new technologies, the research on drug sustained-release stent systems has become more in-depth. During the operation, it was found that when the stent is implanted in the blood vessel, due to the expanded support of the metal or non-metallic stent, the inner wall of the blood vessel will inevitably be scratched, thereby causing damage. After surgery, patients need to take anticoagulant drugs to prevent blood clots from forming. Compared with bare stents without drug coating, vascular endothelial cells can heal automatically within 30 days...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/16A61L29/08A61L29/16
Inventor 陈毅生胡铁锋张秀丽
Owner 上海赢生医疗科技有限公司
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