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Endotracheal tube with long-acting bacterial adhesion prevention and preparation method of endotracheal tube

An anti-bacterial adhesion, endotracheal catheter technology, applied in catheters, coatings, etc., can solve the problem of difficult treatment of BCI, and achieve the effect of lasting antibacterial effect, good visible light-induced sterilization performance, and high chemical stability.

Inactive Publication Date: 2014-07-23
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These factors make BF on the surface of PVC tracheal tube an important and continuous source of BCI pathogenic bacteria, making BCI difficult to treat effectively with drugs in clinical practice

Method used

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  • Endotracheal tube with long-acting bacterial adhesion prevention and preparation method of endotracheal tube
  • Endotracheal tube with long-acting bacterial adhesion prevention and preparation method of endotracheal tube
  • Endotracheal tube with long-acting bacterial adhesion prevention and preparation method of endotracheal tube

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] 2. Preparation of iodine-containing photocatalytic antibacterial sol

[0031] Firstly, Ti(OH) was prepared by the traditional sol-gel method. 4 , Zn(OH)2 , Al(OH) 3 Sol, and then these sols and iodine compound solutions are mixed evenly, and then these mixed solutions are placed in a stainless steel high-pressure reaction kettle with a polytetrafluoroethylene lining and carried out airtight heat treatment at a certain temperature, and the treatment time is 12- 48h. The semiconductor composite oxide antibacterial sol containing different forms of iodine was prepared.

Embodiment 1

[0032] Example 1 Iodine-containing Ti(OH) 4 Sol preparation

[0033] Using tetrabutyl titanate as raw material, add the ethanol solution of tetrabutyl titanate dropwise to the aqueous solution under acidic conditions, and stir vigorously at room temperature for 24-36 h to obtain light blue Ti(OH) 4 Sol, the particle size distribution of the sol is 20-40 nm. Then, measure 1ml of an aqueous solution with a concentration of 1M potassium periodate and slowly add it dropwise to the Ti(OH) 4 sol, and then heat-treated in an autoclave at a temperature of 120-180°C for 12-30 h to obtain iodine-containing Ti(OH) 4 Sol antibacterial sol, denoted as I / Ti(OH) 4 .

Embodiment 2

[0034] Example 2 Iodine-containing Ti(OH) 4 -Al(OH) 3 Sol preparation

[0035] First, weigh 0.05mol of Al(NO) 3 Dissolve it in 100 ml deionized water, slowly add ammonia water dropwise under strong stirring at 40 °C to pH=8~9, and then stir at constant temperature for 3 h to obtain Al(OH) 3 Sol. Then, take 10ml Al(OH) 3 The sol was slowly added dropwise to 100ml Ti(OH) with vigorous stirring 4 Sol, after stirring evenly, according to Example 1, the iodine solution is mixed with the composite sol to obtain iodine-containing Ti(OH) 4 -Al(OH) 3 Mixed sol, denoted as I / Ti(OH) 4 -Al(OH) 3 .

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Abstract

The invention provides an endotracheal tube with long-acting bacterial adhesion prevention and a preparation method of the endotracheal tube. A surface chemical self-assembling method is adopted to carry out surface modification on a medical PVC endotracheal tube; by virtue of steps such as surface modification of the PVC endotracheal tube, synthesis of antibacterial sol, chemical reaction of a substrate surface and surface of antibacterial liquor, so that photocatalysis antibacterial components are uniformly and firmly loaded on the surface of the endotracheal tube to form a film, so that the surface-modified endotracheal tube has good bacterial adhesion prevention and visible-light induced sterilization performance, is lasting in antibacterial effect and high in chemical stability.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, and in particular relates to a trachea tube with long-acting anti-bacterial adhesion and a preparation method thereof. Background technique [0002] Biomedical materials are an important branch of materials science, and they have been widely used in many aspects such as artificial organs, surgical repair, physical therapy rehabilitation, diagnosis, and treatment of diseases. The medical application of these materials has greatly promoted the rapid improvement of medical treatment, but at the same time it also provides opportunities for bacteria to invade the host. According to reports, the number of cases of Biomaterial centered infections (BCI) has increased year by year in recent years. The study of the nature of bacterial adhesion on the surface of biomaterials and the development of new antibacterial biomaterials have attracted more and more attention. [0003] Among many biological ...

Claims

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Application Information

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IPC IPC(8): A61L29/16C08J7/12C08J7/04
Inventor 林华香邓韦华王绪绪龙金林张子重林群
Owner FUZHOU UNIV
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