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3D-printing-based machining method of three-dimensional micro-fluidic chip and printing device

A microfluidic chip and 3D printing technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve problems such as easy collapse and lack of support, and achieve high production efficiency, low processing cost, Conducive to the effect of industrial batch manufacturing

Active Publication Date: 2014-07-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method prints a soluble three-dimensional microchannel solid structure at one time, but in the actual production process, there is a problem that the three-dimensional microchannel structure is easy to collapse due to the lack of necessary support.

Method used

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  • 3D-printing-based machining method of three-dimensional micro-fluidic chip and printing device
  • 3D-printing-based machining method of three-dimensional micro-fluidic chip and printing device
  • 3D-printing-based machining method of three-dimensional micro-fluidic chip and printing device

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Experimental program
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Effect test

Embodiment 1

[0042] 1) First, prepare a mixture of polydimethylsiloxane (PDMS) and a curing agent (the curing agent is a curing agent matched with polydimethylsiloxane in the prior art) with a mass ratio of 10:1, Used as a chip material, a layer of the above mixture is pre-cast on the molding substrate, and the bottom surface of the three-dimensional microfluidic chip is obtained after it is cured;

[0043] 2) Spray solvent-soluble microchannel solid materials layer by layer on the bottom surface of the chip to prepare a three-dimensional microchannel solid structure, including:

[0044] a) Use CAD software (CorelDraw) to design and draw a three-dimensional microfluidic diagram, the three-dimensional microfluidic diagram is as follows image 3 As shown, the flow channel inlet 31 and the flow channel outlet 32 ​​have been pre-designed, located on the same side of the chip, and adopt a vertical liquid inlet method;

[0045] b) Use commercial CAD software such as CorelDraw for preprocessing ...

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Abstract

The invention discloses a 3D-printing-based machining method of a three-dimensional micro-fluidic chip. The machining method comprises the following steps: (1) drawing a three-dimensional micro-runner figure; (2) layering three-dimensional runners in the three-dimensional micro-runner figure, and carrying out layer-by-layer slicing on the three-dimensional runners along the bottom surface direction parallel to a chip; (3) pouring a liquid-state chip material on a micro-runner solid structure at a previous layer, sequentially printing the micro-runner solid structure and pouring the chip material on each layer according to layering and slicing sequences of the runners, and sequentially finishing the shape printing of the runners, so as to obtain a three-dimensional runner solid structure; (4) dissolving the three-dimensional runner solid structure, so as to obtain the three-dimensional micro-fluidic chip. The invention further discloses a printing device for implementing the method. The 3D-printing-based machining method has the advantages that a machining process is simple, convenient and rapid, the production efficiency is high, the industrial mass production is easily realized, the obtained three-dimensional micro-fluidic chip does not need to be subjected to post-processing processes such as bonding, a packaging process is simplified, a three-dimensional micro-runner with a complex structure can be manufactured, and the shape and precision of the runner are controllable.

Description

technical field [0001] The invention relates to the field of micro-nano processing, in particular to a processing method and printing device for a three-dimensional microfluidic chip based on a 3D printing method. Background technique [0002] Microfluidics integrates the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis processes into one chip to automatically complete the analysis process. Due to its great potential in the fields of biology, chemistry, and medicine, it has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. [0003] Microfluidic chip is the main platform for the realization of microfluidic technology. The main characteristic of microfluidic chip is that its fluid-accommodating channels, reaction chambers and some other functional components are micron-scale in at least one latitude. Due to ...

Claims

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Application Information

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IPC IPC(8): B29C67/00B01L3/00
Inventor 贺永邱京江傅建中肖箫吴燕
Owner ZHEJIANG UNIV
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