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Pharmaceutical composition for treating insomnia

A composition and drug technology, applied in the field of drugs for the treatment of insomnia, orally disintegrating tablets of vilazodone hydrochloride, which can solve the problems of no research reports on the application progress of vilazodone hydrochloride

Inactive Publication Date: 2014-07-02
BEIJING KEYUAN CHUANGXIN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the application progress of vilazodone hydrochloride in the treatment of insomnia and improvement of sleep quality

Method used

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  • Pharmaceutical composition for treating insomnia
  • Pharmaceutical composition for treating insomnia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]

[0019] Preparation method: Airflow pulverize vilazodone hydrochloride to 1 micron to 20 microns (90% of the particle size should fall within the required particle size range) for later use; take the prescribed amount of vilazodone hydrochloride and the wood added in the prescription Sugar alcohol, lactose, cross-linked sodium carboxymethyl cellulose, aspartame, and citric acid are mixed evenly, and an appropriate amount of purified water is added to wet granulate, dried, and an additional amount of cross-linked carboxymethyl cellulose is added to the dry granules Sodium cellulose and cherry essence are mixed evenly, pressed into tablets, and made into 1000 tablets.

Embodiment 2

[0021]

[0022] The preparation method is as follows: crush vilazodone hydrochloride by air flow to 1 micron to 20 microns (90% of the particle size should fall within the required particle size range) for later use; take the prescribed amount of vilazodone hydrochloride and the The water-soluble filler, disintegrating agent, flavoring agent, lubricant, and glidant are mixed evenly, and directly compressed into 1000 tablets.

Embodiment 3

[0023] Example 3 Animal experiment of vilazodone hydrochloride sedative hypnosis and improvement of sleep quality.

[0024] Experimental materials: clean male SD rats (SPF grade, from the Experimental Animal Center of Beijing Medical University), weighing 180-200g, feeding conditions: room temperature (22±1)°C, humidity (50.4±10)%, 12 hours of light -Dark rhythmic cycle, free drinking and eating.

[0025] Experimental method: The administration groups are: normal saline blank control group, vilazodone hydrochloride low, medium and high dose groups, the doses are 5mg / kg, 7.5mg / kg, 10mg / kg, the corresponding doses of virazodone hydrochloride The ketone suspension was administered by intragastric administration in an appropriate amount of normal saline. Record the time when the righting reflex disappears and the time when the righting reflex begins for each rat. The time from intragastric administration of vilazodone hydrochloride to the disappearance of righting reflex was cou...

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Abstract

The invention discloses use of a pharmaceutical composition in a medicament for treating insomnia. The study finds that a novel medicament vilazodone hydrochloride for treating a major depressive disorder generates sedative-hypnotic action and treats insomnia of animals at the dosage lower than the clinical recommended dose. The invention also discloses preparation forms of the pharmaceutical composition for treating insomnia, preferably orally disintegrating tablets, components of the disintegrating tablets, and a preparation method thereof. The clinical research shows that the medicament disclosed by the invention is free of obvious toxic and side effects, significant in effect on treatment of insomnia, quick to take effect, convenient to use, and easy to accept by a sufferer. A new choice is provided for treatment of insomnia, and the pharmaceutical composition has a broad market prospect.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the use of a pharmaceutical composition in a medicine for treating insomnia, and more specifically designs the use of an orally disintegrating tablet of vilazodone hydrochloride in a medicine for treating insomnia. Background technique [0002] Insomnia is the inability to fall asleep or stay asleep, resulting in a lack of sleep. Disorders of initiating and maintaining sleep (DIMS), also known as disorders of initiating and maintaining sleep (DIMS), is a disease characterized by frequent inability to obtain normal sleep, difficulty in falling asleep, deep or frequent sleep, early awakening, and insufficient or poor quality sleep caused by various reasons Common causes of insomnia mainly include environmental factors, individual factors, physical factors, mental factors, emotional factors, etc. With the acceleration of industrialization, the intensification of work pressure a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/20A61P25/20
Inventor 李晓红
Owner BEIJING KEYUAN CHUANGXIN TECH
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