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Detection control device for anesthetics in blood

A technology for detection control and anesthetics, which is applied to measurement devices, flow monitors, and devices introduced into the body, etc., can solve the problems of poor accuracy of results, difficulty in obtaining medicine boxes, and lack of selectivity of RIA method, and achieve the effect of improving detection sensitivity.

Inactive Publication Date: 2014-06-25
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, GC determination is quite difficult, RIA method lacks selectivity, and it is also difficult to obtain a kit
In 1988, the use of high performance liquid chromatography (HPLC) was discussed, and it is still used today, but the accuracy of the results is very poor

Method used

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  • Detection control device for anesthetics in blood
  • Detection control device for anesthetics in blood
  • Detection control device for anesthetics in blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Propofol anesthetic sample obtained an ideal detection signal in negative ion mode, and the ion mobility spectrometry rapid detector used in the experiment was under the experimental operating conditions, and the air reagent ion peak appeared at about 5ms (such as Figure 10 ).

Embodiment 2

[0066] Take a blood sample of 1-50 μL with a micro-sampler at the sampling place of the sampling chip. In the negative ion mode, the ion mobility spectrometer is used as the detection instrument, and the carrier gas carries the thermally desorbed blood sample vapor into the ion mobility spectrometer for analysis and detection. There is no obvious background signal at 8.3ms to interfere with the detection of propofol anesthetics, such as Figure 11 shown. The blood blank background signal averages about 45mv at 8.3ms, which can be set as the background threshold for subtracting the background signal.

Embodiment 3

[0068] Qualitative analysis test: Take 1-50μL blood sample solution containing 0.5-20ppm anesthetics with a micro-sampler at the sampling place of the sampling piece. In the negative ion mode, the ion mobility spectrometer is used as the detection instrument, and the carrier gas carries the anesthetic sample vapor after thermal analysis into the ion mobility spectrometer for analysis and detection; the experiment takes a blood sample containing propofol anesthetic as an example, and the ion mobility Under the experimental operating conditions of the spectrum detector, the signal peak migration time of the propofol anesthetic sample is about 8.3ms. 1ppm, 5ppm, 10ppm, and 20ppm blood medicine are analyzed by the method of the present invention and the average signal (without deducting the background signal) is 100mv, 325mv, 526mv, 1120mv (such as Figure 12-15 shown).

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Abstract

The invention discloses a detection control device for anesthetics in blood. The detection control device comprises an anesthetic patient blood receiver (BR). Detection limit and qualitative and quantitative analytical concentration of the blood are detected, analyzed and acquired by the aid of an ion mobility spectrometry (IMS) system or a mass spectrometry (MS) system or an ion mobility spectrometry and mass spectrometry (IMS-MS) combination system, so that the requirement of the human blood on an administration concentration analysis range can be met, and an analytical method for quickly detecting the anesthetics in the blood can be created; analysis results are accurately displayed via a computer software system and include pharmacokinetic models and parameters relevant to medicine infusion; a medical target control infusion (TCI) system can be directly guided by the output results, and hardware of the medical target control infusion system comprises medical infusion pumps, a personal computer (PC) and a safety system mechanism, the infusion pumps can run under the control of the personal computer, and the personal computer can be switched off by the safety system mechanism when the errors occur. The detection control device has the advantages that the detection control device can be used easily and conveniently, is speedy, is high in efficiency and good in reliability, can be automatically controlled, can be widely applied to clinical administration depth analysis and can be used for guiding doctors to accurately apply medicine to the blood in an online manner.

Description

technical field [0001] The invention discloses a detection and control device for anesthetics in blood. The detection and control device includes: a blood receiver (BR) for an anesthetized patient; The combined system (IMS-MS) detection and analysis obtains the measurement detection limit and quantitative analysis concentration to meet the analysis range of human blood administration concentration, and establishes an analysis method for rapid detection of anesthetics in blood; at the same time, the analysis results are accurately displayed through the computer software system, including Pharmacokinetic model and parameters related to drug infusion; this output directly guides the medical target-controlled infusion system (TCI), whose hardware includes a medical infusion pump, a computer (PC) that controls the operation of the infusion pump, and A safety system mechanism that shuts down when an error occurs; the detection device is easy to use, fast, efficient, and reliable, an...

Claims

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Application Information

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IPC IPC(8): A61M5/172G01N27/62G01N27/623
Inventor 王新李海洋渠团帅李杭王祯鑫陈文东
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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