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Preparing method for small-sized pig 2-type diabetes model

A technology for type 2 diabetes and miniature pigs, which can be used in preparations for in vivo experiments, pharmaceutical formulas, animal feeds, etc., can solve the problems of immature production models of transgenic technology, the scarcity of spontaneously diabetic minipigs, and the high cost. The effect of strong repeatability, low cost and easy operation

Inactive Publication Date: 2014-06-18
GUANGXI UNIV
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Problems solved by technology

[0004] However, it is very difficult to establish a large animal type 2 diabetes model, establish a standard modeling scheme and judgment criteria, and the probability of obtaining a spontaneously diabetic miniature pig is very rare. The technology of using transgenic technology to make a model is not yet mature, and the cost is high

Method used

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  • Preparing method for small-sized pig 2-type diabetes model
  • Preparing method for small-sized pig 2-type diabetes model
  • Preparing method for small-sized pig 2-type diabetes model

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Experimental program
Comparison scheme
Effect test

Embodiment

[0040] 1. Preparation of mini-pig type 2 diabetes model and test indicators and methods

[0041] 1.1 Induced diabetes model

[0042] To avoid changes in the feed intake of miniature pigs caused by changes in diets, at the beginning of the experiment, the feeding requirements of miniature pigs were slowly transitioned from conventional diets to high-fat and high-sugar diets; the increment of sucrose per meal was 1.5% of the feeding amount , the lard increment was 0.5% of the feeding amount, until it was increased to the experimental level of high-fat and high-sugar diet.

[0043] The high-fat and high-sugar diet was fed at a rate of 3% of the body weight, fed twice a day in the morning and evening at fixed times, with free access to water, and fed for 300 days.

[0044] 1.2 Index determination and method

[0045] During the formal test period, blood was collected from the anterior vena cava every 30 days.

[0046] The animals were fasted for 16 hours, weighed, blood was coll...

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Abstract

The invention discloses a preparing method for a small-sized pig 2-type diabetes model. The method comprises the steps of feeding high-fat high-sugar daily feed to a small-sized pig, continuously feeding for 280-320 days, wherein the high-fat high-sugar daily feed comprises the following components of 55-65 parts of complete feed, 25-35 parts of sugar and 5-15 parts of animal source fat. The small-sized pig 2-type diabetes obtained by the preparing method can be used for screening medicines for treating the 2-type diabetes model. The method is simple in step, convenient to operate and lower in cost, can be used for inducing the small-sized pig to present the impaired glucose tolerance and insulin resistance, the clinical features of the 2-type diabetes occur, a modeling success judgment standard is determined, the repeatability is strong, and the obtained small-sized pig 2-type diabetes model can be used for researching and screening the medicines for treating the 2-type diabetes model and has wide application prospect.

Description

technical field [0001] The invention relates to a method for preparing a miniature pig type 2 diabetes model. Background technique [0002] In recent years, the global prevalence of diabetes has shown a rapid upward trend. Statistics from the World Health Organization in 2011 show that the number of diabetic patients in the world has reached 366 million, and it is estimated that the global incidence will reach 439 million by 2030. The prevalence of diabetes among residents aged 18 and over in my country is 9.7%, and the prevalence of elderly people over 60 years old is as high as 19.6%. There are about 97 million adult diabetic patients in the country. Diabetes has become a major threat to the health of our population, especially the health of the elderly Major diseases have greatly increased the cost of social pensions. This problem will become increasingly acute in the future with the increasing proportion of the elderly population in our country. According to the differen...

Claims

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Application Information

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IPC IPC(8): A01K67/02A23K1/18A23K1/16A61K49/00
Inventor 兰干球杨辉蒋钦杨郭亚芬陈江伟梁家充
Owner GUANGXI UNIV
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