Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof

A technology for diabetic nephropathy and a composition is applied in the field of traditional Chinese medicine compositions for the treatment of diabetic nephropathy and the field of preparation thereof, which can solve problems such as incomplete elucidation of the pathogenesis, and achieve the effects of improving renal function, easy preparation and molding, and reducing urinary protein.

Active Publication Date: 2014-06-04
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diabetic nephropathy is the most important cause of end-stage renal disease (ESRF), and one of the main causes of death in diabetic patients. A lot of research has been done on this at home and abroad, but the pathogenesis has not been fully elucidated so far, and there is no effective drug prevent its occurrence and deterioration

Method used

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  • Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof
  • Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof
  • Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] (1) Weigh Chinese herbal medicines according to the following weight proportions, 20 parts of Astragalus membranaceus, 10 parts of Rosa laevigata, 10 parts of Rhizoma Chuanxiong, 15 parts of hollyhock flower, 5 parts of rhubarb, 15 parts of Dahuacao, and 10 parts of Pueraria lobata.

[0107] (2) Add astragalus, kudzu root, chuanxiong, and hollyhock flowers to 12 times the weight of 63% ethanol for reflux extraction twice, each time for 150 minutes, and collect the extract.

[0108] Determination of the contents of astragaloside IV, hyperoside and puerarin by high performance liquid chromatography. Determination of the content of astragaloside IV, detector: evaporative light scattering detector; the chromatographic column of high performance liquid chromatography is C 18 ; Mobile phase: acetonitrile-water (32:68); Mobile phase flow rate: 1.0 mL / min; Drift tube temperature: 101° C.; Carrier gas flow rate: 2.7 L / mL; Determination of hyperin and puerarin content, detector:...

Embodiment 2

[0117] The Chinese medicinal materials were weighed according to the following weight proportions, 15 parts of Astragalus membranaceus, 13 parts of Fructus Rosa, 7 parts of Rhizoma Chuanxiong, 15 parts of Sunflower of hollyhock, 3 parts of rhubarb, 15 parts of Rhizoma chinensis, and 13 parts of Pueraria lobata.

[0118]Add Radix Astragali, Pueraria Radix Puerariae, Ligusticum Chuanxiong, and hollyhock flowers by weight to 14 times of 50% ethanol to reflux and extract once, each time for 180 minutes, collect the extract, and use the same method as in Example 1 to measure the content of astragaloside IV as 1.3074mg / g, the content of puerarin is 39.6242mg / g, the content of hyperin is 7.1072mg / g, be concentrated to the clear cream that relative density is 1.1; Water reflux extraction 2 times, each 1 hour, collect extract, adopt the method identical with embodiment 1 to measure the content of rhein to be 2.7084mg / g, be concentrated to the clear cream that relative density is 1.1; ...

Embodiment 3

[0120] The Chinese medicinal materials were weighed according to the following weight proportions, 20 parts of Astragalus membranaceus, 7 parts of Fructus Rosa, 10 parts of Rhizoma Chuanxiong, 10 parts of hollyhock flower, 3 parts of rhubarb, 10 parts of Rhizoma chinensis, and 7 parts of Pueraria lobata.

[0121] Astragalus, Radix Puerariae, Rhizoma Chuanxiong, and hollyhock flowers were added by weight with 8 times of 70% ethanol to reflux and extract 4 times, each time for 30 minutes, the extract was collected, and the content of astragaloside IV was measured in the same way as in Example 1 to be 1.2099mg / g, the content of puerarin is 40.2475mg / g, the content of hyperin is 7.0431mg / g, be concentrated to the clear paste that relative density is 1.1; Add rhubarb, Rosa laevigata, Scutellaria chinensis 8 times by weight Water reflux extracts 4 times, each 0.5 hour, collects extract, adopts the method identical with embodiment 1 to measure the content of rhein to be 2.5489mg / g, b...

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Abstract

The invention relates to a Chinese medicinal composition for treating diabetic nephropathy. The Chinese medicinal composition is prepared from the following Chinese medicinal decoction pieces in parts by weight: 15-25 parts of astragalus, 7-13 parts of cherokee rose fruit, 7-13 parts of Szechuan lovage rhizome, 10-20 parts of sunset abelmoschus flower, 2-8 parts of rhubarb, 7-13 parts of kudzuvine root and 10-20 parts of common achyranthes herb. An oral preparation of the traditional Chinese medicine is prepared by the following steps: extracting the astragalus, the Szechuan lovage rhizome, the sunset abelmoschus flower and the kudzuvine root by using ethanol; collecting an extracting solution and concentrating into clear paste of which the relative density is 1.08-1.15; extracting together with the cherokee rose fruit, the rhubarb and the common achyranthes herb by using water; collecting an extracting solution and concentrating to clear paste of which the relative density is 1.08-1.5; mixing the two clear pastes; continually concentrating into thick paste of which the relative density is 1.30-1.40; adding auxiliary materials to obtain a dosage form suitable for clinical application. A prepared Chinese medicinal oral preparation has the advantages of high extraction efficiency of effective components, stable content, good medicinal effect, low dosage and easiness in preparation and formulation.

Description

technical field [0001] The invention relates to traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating diabetic nephropathy and a preparation method thereof. Background technique [0002] Diabetic nephropathy (DN) is one of the common and serious chronic complications of diabetes, and it is also the main cause of death in diabetic patients. Diabetes lasts for 10-20 years. It is reported that the incidence of DN is about 40-50% in type 1 diabetes and 30-40% in type 2 diabetes. DN is the main microvascular complication of diabetes, mainly referring to diabetic glomerulosclerosis, a glomerular lesion mainly caused by vascular damage. It is mostly asymptomatic in the early stage, and its incidence increases with the prolongation of the course of diabetes. In the early stage of diabetes, the kidney volume increases, the glomerular filtration rate increases, and it is in a state of high filtration. Later, intermittent proteinuria ...

Claims

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Application Information

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IPC IPC(8): A61K36/738A61K9/16G01N30/02A61P3/10A61P13/12
Inventor 龚慕辛翟永松尚雅文高彦彬
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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