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Oral composition

A composition and oral technology, applied in oral care, drug combination, cosmetic preparations, etc., can solve the problem of not knowing the use of oral composition components

Active Publication Date: 2014-05-28
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its use as an ingredient in oral compositions is not yet known

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1～1-30 and comparative example 1-1～1-4

[0390] [Main raw materials used]

[0391] [(A) Component]

[0392] (1) Pyrrolidone carboxylic acid (γ-lactam compound):

[0393] Manufactured by Ajinomoto Co., Ltd., brand name "AJIDEW A-100 (registered trademark)"

[0394] (2) 6-oxo-2-piperidinecarboxylic acid (δ-lactam compound):

[0395] Manufactured by Sigma-Aldrich Japan Co., Ltd. (Japanese: Sigma Aldrich Japan Co., Ltd.), trade name "(S)-6-oxo-2-piperidine carboxylic acid ((S)-6-Oxo-2-piperidine carboxylic acid) "

[0396] (3) 3-(2-oxo-1-azepanyl)propanoic acid (ε-lactam compound):

[0397] Sigma-Aldrich Japan Co., Ltd., trade name "3-(2-oxoazepan-1-yl)propanoic acid (3-(2-Oxoazepan-1-yl)propanoic acid)"

[0398] [Comparison of (A) Component]

[0399] (4) Polyvinylpyrrolidone (lactam compound without acidic groups):

[0400] Manufactured by Wako Pure Chemical Industries, Ltd., brand name "polyvinylpyrrolidone K25 (Japanese: ポリビニルピロリドン K25)"

[0401] (5) Proline (cyclic amino acid):

[0402] Manufactured by Wako Pu...

Embodiment 2-1～2-36 and comparative example 2-1～2-6

[0532] [Main raw materials used]

[0533] [(A) Component]

[0534] (1) Pyrrolidone carboxylic acid (γ-lactam compound):

[0535] Manufactured by Ajinomoto Co., Ltd., brand name "AJIDEW A-100 (registered trademark)"

[0536] (2) 6-oxo-2-piperidinecarboxylic acid (δ-lactam compound):

[0537] Manufactured by Sigma-Aldrich Japan Co., Ltd., trade name "(S)-6-oxo-2-piperidinecarboxylic acid"

[0538] (3) 3-(2-oxo-1-azepanyl)propanoic acid (ε-lactam compound):

[0539] Manufactured by Sigma-Aldrich Japan Co., Ltd., trade name "3-(2-oxoazepan-1-yl)propionic acid"

[0540] [Comparison of (A) Component]

[0541](4) Polyvinylpyrrolidone:

[0542] Manufactured by Wako Pure Chemical Industries, Ltd., brand name "Polyvinylpyrrolidone K25"

[0543] [(2-B) Components]

[0544] (5) Longan core extract (used in Examples and Comparative Examples other than Examples 2-12 and 2-13):

[0545] Manufactured by Katakura Chikkarin Co., Ltd. (Japanese: Katakura Chikkarin Co., Ltd.), trade name...

Embodiment 12 and 13

[0547] (6) Longan core extract (used in Examples 12 and 13):

[0548] Manufactured by Katakura Chikkarin Co., Ltd., brand name "Longan Kernel Extract Powder SD"

[0549] Longan core extract content: 83%;

[0550] (7) Proanthocyanidins:

[0551] Manufactured by Kikkoman Co., Ltd. (Japanese: キッコーマン Co., Ltd.), trade name "Gravinol-SL"

[0552] Proanthocyanidin content: 82%

[0553] (8) Catechin:

[0554] Manufactured by Sun Chemical Co., Ltd., trade name "Sunphenon EGCG"

[0555] Catechin content: 95%

[0556] (9) Hesperidin:

[0557] Manufactured by Tokyo Chemical Industry Co., Ltd., trade name "methyl hesperidin (Japanese: メチルヘス ペ Lijin)”

[0558] Hesperidin content: 90%

[0559] [Comparative product for (2-B) component]

[0560] (10) Rosemary extract:

[0561] Manufactured by Maruzen Pharmaceutical Co., Ltd., brand name "RKC-87"

[0562] Rosemary extract content: 1.5%

[0563] The mixing rate of each polyphenol compound shown in Tables 12-16 is the mixing rate wh...

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Abstract

The purpose of the present invention is to provide a sole component that can exhibit a function as an oral composition, such as the prevention of dentinal caries, the prevention or amelioration of dentin hypersensitivity, the inhibition of the formation of stains, the removal of stains or the like, or a combination of two or more of such components. The present invention provides an oral composition containing a component (A) which is a compound having at least one lactam skeleton selected from the group consisting of a gamma-lactam skeleton, a delta-lactam skeleton and an epsilon-lactam skeleton and also having an acidic group and / or a salt of the compound.

Description

technical field [0001] The present invention relates to a composition for oral cavity. Background technique [0002] The gums in the oral cavity tend to shrink due to periodontal disease or aging of the body. If the gums recede, the roots (roots) of the teeth that were not exposed become exposed. The root of the tooth exists in the state where the dentin is not covered by the enamel. Because dentin has numerous small tubule structures, it also contains more organic matter layers mainly composed of collagen, so its mineral density is low, about 50%, which is about 97% of that of enamel. In comparison, it is physically and chemically fragile. Therefore, if the root of the tooth is exposed in the oral cavity due to receding gums, caries (dentine caries) is prone to occur. Such dentin caries of the tooth root starting from exposure of the tooth root is called root surface caries. [0003] The pathogenesis of dentin caries (root caries) is as follows: First, plaque is attach...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/21A61K8/64A61Q11/00
CPCA61K8/4913A61K8/4926A61K8/498A61K8/97A61Q11/00A61K8/24A61K8/365A61K8/4906A61K8/731A61K8/21A61P1/02A61P43/00A61K8/64
Inventor 井上志磨子藤川晴彦朝熊弘树鬼木隆行福田康
Owner LION CORP
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