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Preparation of Glabridin dispersible tablets and use of the tablets in reducing blood sugar as medicament active composition

A technology of licorice flavonoids and drug activity, which is applied in the field of experimental research on hypoglycemic activity of licorice flavonoids dispersible tablets, can solve the problems of high price, cannot be used for a long time, large toxic and side effects, etc., achieves low cost, is suitable for long-term use, and has toxic and side effects. low effect

Active Publication Date: 2009-01-21
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs are not only expensive, but also have large toxic and side effects in clinical application, so they cannot be used for a long time

Method used

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  • Preparation of Glabridin dispersible tablets and use of the tablets in reducing blood sugar as medicament active composition
  • Preparation of Glabridin dispersible tablets and use of the tablets in reducing blood sugar as medicament active composition
  • Preparation of Glabridin dispersible tablets and use of the tablets in reducing blood sugar as medicament active composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 2000g of licorice slices, reflux and extract 3 times according to the ratio of 1:4 of licorice and 95% ethanol, each time for 2h, combine the filtrates 3 times, and recover the solvent by distillation under reduced pressure to obtain 356g of extract, pass the obtained extract through 30-60 mesh Polyamide column chromatography, eluted with water and 95% ethanol in sequence, detected by hydrochloric acid-magnesium powder reaction, combined to obtain total flavonoids. After concentration and freeze-drying, 82.45 g of total flavonoid powder was obtained, with a yield of 4.12%. Weigh 4% CMS-Na, 4% L-HPC, 1.5% SLS and 20% flavonoid powder according to the prescription quantity, add appropriate amount of MCC, pass through a 100 mesh sieve and mix evenly, after drying at 60°C, directly compress into tablets (each tablet contains effective ingredients 250mg).

[0020] Preparation technology of licorice flavone dispersible tablet (LFT)

[0021] (1) optimization of prepara...

experiment example 2

[0050] Experimental Example 2 Application of Licorice Flavone Dispersible Tablets as Active Ingredients in Hypoglycemia

[0051] (1) Experimental study on the effect of licorice flavone dispersible tablet (LFT) on blood sugar in mice

[0052] (1) Effect of Licorice Flavone Dispersible Tablets on Blood Glucose in Alloxan-Induced Diabetic Mice

[0053] Take 85 Kunming mice, half male and half female, and fast for 12 hours. Except for the normal control group, each group is intraperitoneally injected with alloxan (200ml / kg), and the normal control group is intraperitoneally injected with the same amount of normal saline. Glucose level, select the blood glucose value to carry out the test more than 16mmol / L, mice are divided into normal control group, model group, Baitangoping group (25mg / kg), LFT high-dose group (150ml / kg), LFT middle-dose group ( 100mg / kg), the LFT low-dose group (50mg / kg), intragastric administration once a day, the control group and the model group were given...

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Abstract

The present invention discloses a preparation process of glycyrrhiza flavonoid dispersible tablet and the application of the tablet as the active component in decreasing blood sugar. The activity test proves three dosage groups of the glycyrrhiza flavonoid dispersible tablet all play a significant role in decreasing blood sugar of hyperglycemic model mice caused by alloxan, adrenalin and dextrose; the role in decreasing blood sugar is equal to or more significant than similar sugar-reducing medicines in clinical use. At the same time, the 'three more and one less' symptom of the diabetic model mouse is obviously relieved and especially the drinking amount is obviously reduced. The mouse acute toxicity test proves that under the maximum dosage, the mouse has no toxic side effect and the weight growth is normal. The source of raw materials is wide, the main sugar-reducing component is taken from natural medicines and the sugar-reducing effect is obvious; therefore, the present invention is suitable for long-term use. The present invention with simple preparation technology and low production cost is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a method for separating and purifying effective hypoglycemic components of the licorice flavonoid dispersible tablet, preparation of the licorice flavonoid dispersible tablet and experimental research on the hypoglycemic activity of the licorice flavonoid dispersible tablet. Background technique [0002] Diabetes mellitus is an endocrine metabolic disease characterized by hyperglycemia due to absolute or relative insufficiency of insulin secretion. If the body is in a state of high blood sugar for a long time, it can lead to various complications such as blindness, renal failure, neuropathy, cardiovascular and cerebrovascular diseases, and gangrene of limbs. It has become the third major disease that seriously endangers human health after cardiovascular and cerebrovascular diseases and cancer. For the treatment of type I diabetes, the research direction is to develop convenient and effective insulin preparations and substitute...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K9/20A61P3/10
Inventor 倪京满王锐许有瑞董莉姚世霞
Owner JIANGSU KANION PHARMA CO LTD
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