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Oral composition

A composition and oral cavity technology, applied in the directions of oral care, drug combination, cosmetic preparations, etc., can solve the problems of unknown use of oral composition components and the like

Active Publication Date: 2016-04-06
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its use as an ingredient in oral compositions is not yet known

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1～1-30 and comparative example 1-1～1-4

[0394] [Main raw materials used]

[0395] [(A) ingredient]

[0396] (1) Pyrrolidone carboxylic acid (γ-lactam compound):

[0397] Manufactured by Ajinomoto Co., Ltd., brand name "AJIDEWA-100 (registered trademark)"

[0398] (2) 6-oxo-2-piperidinecarboxylic acid (δ-lactam compound):

[0399] Sigma Aldrich Japan Co., Ltd. (Japanese: Sigma Aldrich Japan Co., Ltd.), brand name "(S)-6-Oxo-2-piperidinecarboxylic acid ((S)-6-Oxo-2-piperidinecarboxylic acid)"

[0400] (3) 3-(2-oxo-1-azepanyl)propanoic acid (ε-lactam compound):

[0401] Sigma-Aldrich Japan Co., Ltd., trade name "3-(2-oxoazepan-1-yl) propanoic acid (3-(2-Oxoazepan-1-yl) propanoic acid)"

[0402] [comparison product of (A) ingredient]

[0403] (4) Polyvinylpyrrolidone (lactam compound without acidic groups):

[0404] Manufactured by Wako Pure Chemical Industries, Ltd., brand name "polyvinylpyrrolidone K25 (Japanese: ポリビニニルピロリドン K25)"

[0405] (5) Proline (cyclic amino acid):

[0406] Manufactured by Wako Pure Chemi...

Embodiment 2-1～2-36 and comparative example 2-1～2-6

[0536] [Main raw materials used]

[0537] [(A) ingredient]

[0538] (1) Pyrrolidone carboxylic acid (γ-lactam compound):

[0539] Manufactured by Ajinomoto Co., Ltd., brand name "AJIDEWA-100 (registered trademark)"

[0540] (2) 6-oxo-2-piperidinecarboxylic acid (δ-lactam compound):

[0541] Sigma-Aldrich Japan Co., Ltd., trade name "(S)-6-oxo-2-piperidinecarboxylic acid"

[0542] (3) 3-(2-oxo-1-azepanyl)propanoic acid (ε-lactam compound):

[0543] Sigma-Aldrich Japan Co., Ltd., trade name "3-(2-oxoazepan-1-yl)propionic acid"

[0544] [comparison product of (A) ingredient]

[0545](4) Polyvinylpyrrolidone:

[0546] Manufactured by Wako Pure Chemical Industries, Ltd., brand name "Polyvinylpyrrolidone K25"

[0547] [(2-B) component]

[0548] (5) Longan core extract (used in Examples and Comparative Examples other than Examples 2-12 and 2-13): manufactured by Katakura Chikkarin Co., Ltd. (Japanese: Katakura Chikkarin Co., Ltd.), trade name "AGETECT (Japanese : エイジテクト)"

...

Embodiment 12 and 13

[0550] (6) Longan nucleus extract (used in embodiment 12 and 13):

[0551] Manufactured by Katakura Chikkarin Co., Ltd., brand name "Longan Kernel Extract Powder SD"

[0552] Longan core extract content: 83%;

[0553] (7) Proanthocyanidins:

[0554] Manufactured by Kikkoman Co., Ltd. (Japanese: キッコーマン Co., Ltd.), trade name "Gravinol-SL"

[0555] Proanthocyanidin content: 82%

[0556] (8) Catechin:

[0557] Sun Chemical Co., Ltd., trade name "SunphenonEGCG"

[0558] Catechin content: 95%

[0559] (9) Hesperidin:

[0560] Manufactured by Tokyo Chemical Industry Co., Ltd., trade name "Methylhesperidin (Japanese: メチルヘスペリジン)"

[0561] Hesperidin content: 90%

[0562] [comparison product of (2-B) ingredient]

[0563] (10) Rosemary extract:

[0564] Manufactured by Maruzen Pharmaceutical Co., Ltd., brand name "RKC-87"

[0565] Rosemary extract content: 1.5%

[0566] The mixing rate of each polyphenol compound shown in Tables 12-16 is the mixing rate which the polyphenol ...

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Abstract

The purpose of the present invention is to provide a sole component that can exhibit a function as an oral composition, such as the prevention of dentinal caries, the prevention or amelioration of dentin hypersensitivity, the inhibition of the formation of stains, the removal of stains or the like, or a combination of two or more of such components. The present invention provides an oral composition containing a component (A) which is a compound having at least one lactam skeleton selected from the group consisting of a gamma-lactam skeleton, a delta-lactam skeleton and an epsilon-lactam skeleton and also having an acidic group and / or a salt of the compound.

Description

[0001] This application is a divisional application based on the following Chinese patent application: [0002] Application date of the original case: September 28, 2012 [0003] Original application number: 201280047777.2 (PCT / JP2012 / 075223) [0004] Original application name: Composition for oral cavity technical field [0005] The present invention relates to a composition for oral cavity. Background technique [0006] The gums in the oral cavity tend to shrink due to periodontal disease or aging of the body. If the gums recede, the roots (roots) of the teeth that were not exposed before become exposed. The root of the tooth exists in the state where the dentin is not covered by the enamel. Since dentin has numerous small tubule structures, it also contains a large amount of organic matter layer mainly composed of collagen, so its mineral density is low, about 50%, which is about 97% of the mineral density of enamel. In comparison, it is physically and chemically fra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/97A61Q11/00A61P1/02
CPCA61K8/4913A61K8/4926A61K8/498A61K8/97A61Q11/00A61K8/24A61K8/365A61K8/4906A61K8/731A61K8/21A61P1/02A61P43/00A61K8/64
Inventor 井上志磨子藤川晴彦朝熊弘树鬼木隆行福田康
Owner LION CORP
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