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Dendritic polyketal as well as preparation method and application thereof

A dendritic and polyketal technology, which is applied in the field of preparation of dendritic polyketals and derivatives, can solve problems such as blank application research and no relevant reports, and achieve the effect of wide application prospects

Active Publication Date: 2014-05-21
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on dendritic polyketals has just started, especially the preparation of dendritic polyketals with completely regular structures has not yet been reported, and its application research is completely blank.

Method used

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  • Dendritic polyketal as well as preparation method and application thereof
  • Dendritic polyketal as well as preparation method and application thereof
  • Dendritic polyketal as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Preparation of dendritic polyketal G1-[ene] with algebra G=1 4 (The core (C) in the general structural formula I of the aforementioned dendritic polyketal is butanediamine; the terminal group TF is an alkenyl group; D in the general structural formula II of the branch unit is a nitrogen atom, A and B is an alkylene group containing an ester bond, X and Y are a hydrogen atom and a methyl group, respectively).

[0110] 1) Preparation of monomers containing ketal groups (acrylate)-ketal-(methacrylate)

[0111] Dissolve hydroxyethyl acrylate, hydroxyethyl methacrylate, and acetaldehyde in tetrahydrofuran at a molar ratio of 1:1:1, add 0.1 equivalent of pyridinium p-toluenesulfonate (PPTS) and an appropriate amount of 5A molecular sieve, at room temperature After reacting for 3 hours, potassium carbonate was added to terminate the reaction, and the filtrate was retained after filtration to obtain the crude product, and then the crude product was passed through silica gel co...

Embodiment 2

[0117] Preparation of dendritic polyketal G1'-[NH with algebra G=1' 2 ] 4 (The core (C) in the general structural formula I of the aforementioned dendritic polyketal is butanediamine; the terminal group TF is an amine group; D in the general structural formula II of the branch unit is a nitrogen atom, A and B is an alkylene group containing an ester bond, X and Y are a hydrogen atom and a methyl group, respectively).

[0118] The dendritic polyketal G1-[ene] of the algebra G=1 that step (2) obtains in embodiment 1 4 Dissolve cysteamine and cysteamine in dimethyl sulfoxide at a molar ratio of 1:6, and react for 30 minutes at room temperature; after the reaction, add 10 times the volume of dimethyl sulfoxide to dichloromethane for dilution, and then wash with water three times , the organic phase was dehydrated and vacuum dried to obtain a light yellow viscous liquid, which is the dendritic polyketal G1'-[NH 2 ] 4 .

Embodiment 3

[0120] Preparation of dendritic polyketal G2-[ene] with algebra G=2 8 (The core (C) in the general structural formula I of the aforementioned dendritic polyketal is butanediamine; the terminal group TF is an alkenyl group; D in the general structural formula II of the branch unit is a nitrogen atom, A and B is an alkylene group containing an ester bond, X and Y are a hydrogen atom and a methyl group, respectively).

[0121] Repeat the reaction of step (2) in Example 1, only change the charge ratio wherein into the dendritic polyketal G1 '-[NH 2 ] 4 The molar ratio of the ketal group-containing monomer (acrylate)-ketal-(methacrylate) obtained in step (1) in Example 1 is 1:16, and the dendritic polymer with algebra G=2 can be obtained. Ketal G2-[ene] 8 .

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Abstract

The invention relates to dendritic polyketal as well as an application thereof and a preparation method of the dendritic polyketal and a derivative. According to the preparation method, firstly, a monomer R1-ketal-R2 containing a ketal group which is highly sensitive to acid is designed, and subsequently the dendritic polyketal (including the derivative) which is tidy in structure, contains a great amount of tail end active groups or molecules, is highly sensitive to acid and has the structure of the formula in the specification is obtained by using a chemical synthesis method. Due to the property of high sensitivity to acid and the unique structure and property advantages of a dendritic polymer, the dendritic polyketal has a wide potential application prospect in fields such as biologic medicine carriers, gene transfection, bioimaging and medical diagnosis.

Description

technical field [0001] The invention relates to a dendritic polyketal and its application, as well as a preparation method of the dendritic polyketal and its derivatives. Background technique [0002] Dendrimers (Dendrimers) are a new class of synthetic polymer materials that have been booming in recent years. It is a class of polymers with highly branched and completely regular structures obtained through stepwise and repeated reactions of branch units. Due to their many unique properties, such as good monodispersity, a large number of terminal functional groups, numerous internal cavities, good solubility, low viscosity, and easy rheology, dendrimers are now recognized as the next The fourth type of polymer materials after linear polymers, branched polymers and crosslinked polymers. [0003] Since the advent of dendrimers, due to its large number of internal cavities and perfect monodispersity, it has been considered to have good application prospects in the field of biom...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61K47/48A61K49/00C12N15/87
Inventor 吴德成黄达
Owner INST OF CHEM CHINESE ACAD OF SCI
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