Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Implantation fiber membrane used for pelvic floor dysfunction repair, preparation method and medical apparatus containing implantation fiber membrane used for pelvic floor dysfunction repair

A technology for implanting medical devices and dysfunction, applied in medical science, prosthesis, surgery, etc., can solve problems such as unsatisfactory performance of fiber membranes, and achieve favorable adhesion and proliferation, close fit, and large specific surface area Effect

Active Publication Date: 2014-05-21
MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
View PDF7 Cites 25 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the performance of fiber membranes for tissue repair formed by existing weaving or electrospinning techniques is not ideal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Implantation fiber membrane used for pelvic floor dysfunction repair, preparation method and medical apparatus containing implantation fiber membrane used for pelvic floor dysfunction repair
  • Implantation fiber membrane used for pelvic floor dysfunction repair, preparation method and medical apparatus containing implantation fiber membrane used for pelvic floor dysfunction repair
  • Implantation fiber membrane used for pelvic floor dysfunction repair, preparation method and medical apparatus containing implantation fiber membrane used for pelvic floor dysfunction repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] (1) Dissolve polyvinylidene fluoride (PVDF) in a mixed solvent of N,N-dimethylformamide / acetone with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 18g / 100mL to obtain a uniform Fiber material solution A; L-polylactic acid (PLLA) was dissolved in hexafluoroisopropanol (HFIP) solution, so that the concentration of PLLA in the solution was 5g / 100mL, and a uniform fiber material solution B was obtained.

[0131] (2) The above two homogeneous fiber material solutions A and B were filled into five electrospinning syringes respectively, among which 4 syringes were filled with PVDF solution and one syringe was filled with PLLA solution. 4 injection needles corresponding to PVDF solution and 1 injection needle corresponding to PLLA are evenly arranged on the high-voltage power supply board, adjust the rate of the micro-injection pump to 5mL / hour, adjust the voltage of the high-voltage generator to 30KV, and adjust the receiving distance of the receiv...

Embodiment 2

[0135] (1) Dissolve PVDF material in N,N-dimethylformamide / acetone mixed solvent with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 20g / 100mL; prepare a uniform fiber material solution.

[0136] (2) Put the fiber material solution obtained in step (1) into the electrospinning syringe, adjust the rate of the micro-injection pump to 6mL / hour, adjust the voltage of the high-voltage generator to 30KV, and adjust the receiving distance of the receiving device to 25cm , electrospinning is carried out to obtain fiber filaments, and the fiber filaments are received into a film-like structure, and the electrospinning is stopped after spinning until the thickness of the film layer is about 0.5 mm to obtain a fiber film.

[0137] The fiber membrane obtained here has an average fiber diameter of 2 μm, a membrane thickness of 0.5 mm, an average pore diameter of 150 μm, a tensile strength of 32 N / cm, and a bulkiness of 110 cm 3 / g, the softness is 740 millinewt...

Embodiment 3

[0141] (1) Dissolve PVDF material in N,N-dimethylformamide / acetone mixed solvent with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 18g / 100mL; prepare a uniform fiber material solution;

[0142] (2) Put the fiber material solution obtained in step (1) into the electrospinning syringe, adjust the rate of the micro-injection pump to 6mL / hour, adjust the voltage of the high-voltage generator to 30KV, and adjust the receiving distance of the receiving device to 20cm , electrospinning is carried out to obtain fiber filaments, and the fiber filaments are received into a film-like structure, and the electrospinning is stopped after spinning until the thickness of the film layer is about 0.5 mm to obtain a fiber film.

[0143] The fiber membrane obtained here has an average fiber diameter of 2 μm, a membrane thickness of 0.5 mm, an average pore diameter of 190 μm, a tensile strength of 43 N / cm, and a bulkiness of 170 cm 3 / g, the softness is 930 millinewt...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Loftaaaaaaaaaa
Average pore sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides an implantation fiber membrane used for female pelvic floor dysfunction tissue repair. The implantation fiber membrane is characterized by comprising a fluffy fibrous layer (A), wherein the fluffy fibrous layer (A) is formed by interweaving cellosilks with the diameters of 10 nanometers-100 micrometers, and is of a porous structure, the filling power is 400-1500 cm<3> / g, and the softness is 50-500 millinewton. Preferably, the implantation fiber membrane further comprises a directed fibrous layer (B), and the directed fibrous layer (B) is a layer which is formed by the directional alignment of the cellosilks and is of a porous three-dimensional structure.

Description

technical field [0001] The invention relates to an implanted diaphragm, in particular to an implanted diaphragm for treating female pelvic floor dysfunction diseases, a preparation method and a medical device containing the same. Background technique [0002] Affected by factors such as childbirth, disease, and aging, the soft tissue around the pelvic floor is weakened in supporting the pelvic organs, leading to various pelvic floor dysfunction diseases. Pelvic floor dysfunction is a common and frequently-occurring disease in women. Female pelvic floor dysfunction (Pelvic Floor Dysfunction disease, PFD), also known as pelvic floor defect or pelvic floor support tissue relaxation, mainly manifests as prolapse of pelvic organs (such as bladder, uterus, rectum, vagina and small intestine, etc.) Sagging, bulge (Pelvic OrganProlapse, POP) and stress urinary incontinence (Stress Urinary Incontinence, SUI). Both POP and SUI are closely related and have a serious impact on women's...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61F2/02A61B17/00A61L27/50A61L27/54A61L27/40A61L27/18A61L27/20A61L27/22A61L27/24
Inventor 王国帅郭泽跃赖奎霖徐弢袁玉宇
Owner MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com