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Preparation method of pH sensitive multistage polymer composite nanospheres

A nano-microsphere and polymer technology is applied in the field of preparation of multi-level polymer composite nano-microspheres, which can solve the problems of lack of environmental responsiveness, and achieve the effects of simple preparation method, high application value and uniform particle size.

Active Publication Date: 2014-05-14
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of composite microspheres can encapsulate and release drugs, and the drug loading efficiency can be achieved by controlling the size of the microspheres and other factors, but it also lacks environmental responsiveness.

Method used

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  • Preparation method of pH sensitive multistage polymer composite nanospheres
  • Preparation method of pH sensitive multistage polymer composite nanospheres
  • Preparation method of pH sensitive multistage polymer composite nanospheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of functional core-shell nanospheres:

[0022] Add 8 mL of 0.1 mol / L HCl aqueous solution into a 150 mL three-neck flask, seal it with a stopper, place it in a water bath and raise the temperature to 75°C. Slowly drop 200 μL of 4-vinylpyridine into the above aqueous HCl solution. Continue to heat at a constant temperature of 75°C for 10 minutes, add 32 mL of deionized water, and let it fully dissolve for use. Return condensed water to the system at room temperature, and purge with nitrogen protection for 15 minutes, turn on magnetic stirring, slowly add 1000 μL of styrene, and start to heat up. Add accurately weighed 0.04g of potassium persulfate to a 10mL serum bottle, add 10mL of deionized water, and place in an ultrasonic instrument at room temperature for 5 minutes of ultrasonic oscillation. After the temperature of the above system is constant at 75°C, add it quickly. Keep the above conditions unchanged, react for 24h.

[0023] (2) Preparation o...

Embodiment 2～5

[0028] (1) Adjust the volume of the aqueous HCl solution of the same concentration as in Example 1 to 10 mL, 12 mL, and 15 mL, respectively, and add 30 mL, 28 mL, and 25 mL of deionized water, respectively. All the other are with embodiment 1.

[0029] (2) Same as embodiment 1.

[0030] (3) Same as embodiment 1.

[0031] The structures of the obtained monodisperse functional core-shell polymer nanospheres were observed and characterized by transmission electron microscope and scanning electron microscope respectively. From figure 1 A clear core-shell structure can be seen in the medium, and the particle size is less than 200nm. Wherein, the core layer is polystyrene, and the shell layer is poly-4-vinylpyridine. From figure 2 It can be seen that the obtained functional polymer nanospheres have uniform particle size and good dispersion. From image 3 It can be observed that there is a remarkable pH responsiveness when the pH is changed.

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Abstract

The invention provides a preparation method of pH sensitive multistage polymer composite nanospheres and belongs to the technical field of functional polymer materials. The preparation method comprises the steps of adding 4-vinylpyridine to an HCl aqueous solution at 75 DEG C and then adding deionized water, keeping a temperature constant for 10min so that the 4-vinylpyridine is dissolved, removing oxygen by blowing nitrogen, next, adding styrene, stirring, and increasing the temperature to 75 DEG C to obtain a mixed solution A, next, dissolving potassium peroxodisulfate in deionized water, ultrasonically shaking, and after the temperature of the reaction system is constant at 75 DEG C, adding the mixed solution A for continuous reaction to obtain core-shell structured polymer nanospheres, dissolving the emulsion of the polymer nanospheres in HCl solutions different in pH value, and stirring to obtain the pH sensitive multistage polymer composite nanospheres. The preparation method is simple and does not need auxiliaries such as an emulsifier and a surfactant, and the obtained nanospheres are even in particle size and have obvious core-shell structure. When the change of pH is capable of resulting in assembling and disassembling, the pH sensitive multistage polymer composite nanospheres have extremely high application value.

Description

technical field [0001] The invention belongs to the technical field of functional macromolecular materials, and relates to the preparation of multi-level polymer composite nano-microspheres with pH sensitivity. Background technique [0002] With the continuous development of polymer science and technology, the research on polymer composite microspheres is deepening day by day. Polymer composite microspheres refer to microspheres composed of two or more polymers. Using the different characteristics of the polymers, the complementarity between hydrophilicity and hydrophobicity, rigidity and flexibility can be realized. Among them, functional polymer nanocomposite microspheres have become a very important new class of polymer materials due to their special nanoscale size and diverse structures, and are widely used in many fields such as biomedicine, optoelectronics, and magnetism. high research value. [0003] Self-assembly technology is the use of spontaneous mutual recognit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/08C08F226/06C08J3/16
Inventor 戴李宗谢泓辉袁丛辉毛杰罗伟昂何凯斌刘新瑜许一婷曾碧榕
Owner XIAMEN UNIV
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