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Collagen/hydroxyapatite composite coating joint prosthesis implant and preparation method thereof

A hydroxyapatite, artificial joint technology, applied in the direction of coating, can solve the problems of joint loosening, the material and human bone interface cannot be well combined, etc., to promote the link, prevent the prosthesis from loosening, and prolong the service life.

Active Publication Date: 2014-05-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it also has some problems. The incidence of prosthetic loosening can reach 2%-24%. The reason is that the interface between the material and the human bone cannot be perfectly combined, resulting in artificial joint problems such as osteolysis and joint loosening after replacement.

Method used

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  • Collagen/hydroxyapatite composite coating joint prosthesis implant and preparation method thereof
  • Collagen/hydroxyapatite composite coating joint prosthesis implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Commercially pure titanium was cut into 10mm×10mm×1mm square pieces, polished sequentially with 320#, 400#, 600# emery paper, and then placed in acetone, 75% ethanol by volume, and double distilled water for ultrasonic cleaning for 20, 15, After 20 minutes, a titanium plate with a smooth surface was obtained. Grind the smooth titanium plate with 0.25-0.5mm large-grain corundum, and then ultrasonically clean it with acetone, 75% ethanol by volume, and distilled water for 15 minutes each. Extract type I collagen from bovine tendon, mix equal volumes of type I collagen solution (5mg / ml) and carbodiimide solution (5mg / ml), immerse a titanium plate in the mixed solution, and maintain it in a water bath at 37°C for 18 hours to obtain collagen Coated titanium plate, then immerse the collagen-coated titanium plate in PBS solution and sonicate for 10min to remove collagen that is not tightly adhered; 20ml urease solution (1.5mg / ml) with 30ml carbodiimide solution (5mg / ml) Mix, ...

Embodiment 2

[0018] Bone cells were planted on the micro-nano active titanium plate obtained according to the method of Example 1. After culturing for 3 days, the adhesion of bone cells on the surface of the micro-nano-modified titanium plate was observed with a scanning electron microscope, and then the relationship between the titanium plate and bone was evaluated. The biocompatibility of the cells, results such as figure 2 As shown, the adhesion of bone cells on the surface of the titanium plate was good.

Embodiment 3

[0020] A micro-nano active artificial joint implant was implanted into the proximal femur of a dog for hip replacement, and the connection between the artificial joint implant and the surrounding bone tissue was observed. It is found that the composite coating of collagen and hydroxyapatite on the surface of the artificial joint makes the surface have the main components of the natural bone matrix, which promotes the growth of new bone, thereby promoting the link between the bone and the artificial joint.

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Abstract

The invention discloses a collagen / hydroxyapatite composite coating joint prosthesis implant and a preparation method thereof. The surface of a joint prosthesis material is coated with collagen and hydroxyapatite composite sequentially, wherein the thickness of the collagen coating is 10-20 mu m, the porosity of the collagen coating is 90-95 percent, the thickness of the hydroxyapatite coating is 20-50 mu m, and the porosity of the hydroxyapatite coating is 5-15 percent, so that the surface of the joint prosthesis contains a natural bone extracellular matrix ingredient, so that the function of inducing osteogenesis is enhanced, and thus the linkage of bone and an implanted titanium plate is promoted, the joint prosthesis is physiologically fixed, and the difficulty that the joint prosthesis is easy to loosen after being implanted inside in the prior art is effectively solved.

Description

technical field [0001] The invention belongs to the field of orthopedic joints, in particular to a collagen / hydroxyapatite composite coating artificial joint implant and a preparation method. Background technique [0002] With the aggravation of the aging population and the increase of joint damage caused by various injuries, it often leads to changes in the joint structure. Medication alone can only partially relieve pain symptoms, and it is difficult to improve joint function. Artificial joint replacement can achieve the purpose of relieving pain, stabilizing joints, correcting deformities, and improving joint function. Such as pain caused by rheumatoid arthritis, old joint dislocation, etc., through artificial joint surgery, joint deformities can be significantly corrected, and the original stiff joints can return to normal functions. Joint pain and severe dysfunction caused by many diseases are suitable for artificial joint replacement surgery. About 800,000 people arou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/34
Inventor 严伟祺齐义营
Owner ZHEJIANG UNIV
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