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Nano multi-coating medicine stent and preparation method thereof

A multi-coating and coating technology, applied in the field of medical devices, can solve the problems of the degradable coating degrading too fast and cannot effectively inhibit the proliferation of smooth muscle cells, so as to inhibit the proliferation of smooth muscle cells, reduce the risk of bleeding, and reduce the medical burden Effect

Inactive Publication Date: 2014-03-26
中国医科大学附属第四医院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most degradable coatings have the problem that the degradation rate is too fast and cannot effectively inhibit the proliferation of smooth muscle cells.

Method used

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  • Nano multi-coating medicine stent and preparation method thereof
  • Nano multi-coating medicine stent and preparation method thereof
  • Nano multi-coating medicine stent and preparation method thereof

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Embodiment Construction

[0027] The present invention is specifically described below in conjunction with accompanying drawing, figure 1 It is a schematic diagram of the stent structure of the present invention; a nano multi-coated drug stent comprising a stainless steel metal stent 1 covered by a nano ceramic coating 2 covered with a REDV monolayer 3. The REDV monolayer 3 is covered with a PLGA-rapamycin coating 4 .

[0028] The nanocoating 2 includes TiO 2 coating and the TiO 2 The polydopamine film that forms on the coating; The preparation method comprises the following steps:

[0029] 1) Making stainless steel metal brackets: using medical 316L ultra-low carbon stainless steel tubes as raw materials, using laser technology to etch and electropolish to make stainless steel metal brackets;

[0030] 2) Preparation of TiO 2 Coating: TiO was prepared on a 316L support by radio frequency reactive magnetron sputtering 2 coating;

[0031] 3) On TiO 2 Polydopamine film formed on the coating: will h...

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Abstract

The invention discloses a nano multi-coating medicine stent and a preparation method thereof. A stainless steel metal stent is covered by a nano ceramic coating, wherein an REDV (Arg-Glu-Asp-Val) mono-molecule layer is covered outside the nano ceramic coating; a PLGA (Polylactic-co-Glycolic Acid)-rapamycin coating is covered outside the REDV mono-molecule layer. The preparation method of the nano multi-coating medicine stent comprises the following steps: 1) manufacturing the stainless steel metal stent; 2) preparing a TiO2 coating; 3) forming a polydopamine film on the TiO2 coating; 4) creating the REDV mono-molecule layer on the surface of the polydopamine film; 5) preparing a PLGA-RAPA (Rapamycin) solution; 6) forming a medicine coating. The nano multi-coating medicine stent and the preparation method thereof have the advantages of further reducing occurrence rate of in-stent restenosis after a stent implanting operation, suppressing proliferation of smooth muscle cells, accelerating vascular endothelium process, reducing hemorrhage risk caused due to long-term antithrombotic therapy, reducing medical cost of operators and being significant in economic and social benefits.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug support and a preparation method. Background technique [0002] Currently commonly used drug-eluting stents are mainly composed of three parts: (1) Bare metal stent platform: Commonly used bare metal stent materials include 316L stainless steel, cobalt-chromium alloy, etc., because stainless steel materials have good support and X-ray visibility Factors such as low price and low price have become the main material of the bracket platform. However, stainless steel materials contain a variety of metal elements, such as nickel, chromium, and molybdenum, especially the contact allergy caused by the release of nickel ions aggravates the inflammatory response, stimulates the excessive proliferation of vascular tissue fibroblasts around the stent, and increases the regeneration of the stent. narrow. (2) Drug carrier: The drug carrier of drug-eluting stents currently used is mainl...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/16A61F2/91
Inventor 金元哲徐香山
Owner 中国医科大学附属第四医院
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