Medicine coated support frame of blood vessel
A vascular stent and drug technology, applied in the field of medical devices, can solve problems such as the incidence of vascular restenosis not being effectively controlled
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0056] Embodiment 1: As shown in Figure 3, a porous adsorbed drug-coated stent, the surface of the stent 4 is coated with a polymer coating 6 with micropores 5, and the drug is absorbed on the polymer coating 6 by dip coating of microwell 5. Specifically: add 10g of tetraethyl orthosilicate (TEOS) to 10g of water, then add 0.1g of HCL, mix and disperse evenly at 40°C, form a sol in 2 hours, then spray on the surface of the stent, and then place the stent in an oven at 80°C , cured for 24 hours, and then dried at 250-800°C to densify it to form a porous silica gel ceramic-coated scaffold. Then soak the stent in 1%-80% Valsartan (valsartan) or Losartan (losartan) ethanol solution for 1min-60min. After the stent is taken out, the stent is vacuum-dried at 40° C. to remove the solvent, and the valsartan or losartan drug-coated stent adsorbed by porous silica gel ceramics is prepared.
Embodiment 2
[0057] Embodiment 2: As shown in Figure 3, a porous adsorbed drug-coated stent, the surface of the stent 4 is coated with a polymer coating 6 with micropores 5, and the drug is absorbed on the polymer coating 6 by dip coating of microwell 5. Specifically: add 10g of tetraethyl orthosilicate (TEOS) to 10g of water, then add 0.1g of HCL, mix and disperse evenly at 40°C, form a sol in 2 hours, then spray on the surface of the stent, and then place the stent in an oven at 80°C , cured for 24 hours, and then dried at 250-800°C to densify it to form a porous silica gel ceramic-coated scaffold. Then immerse the stent in a dichloromethane solution of Irbesartan (irbesartan) with a concentration of 1%-60% for 1min-60min. After the stent was taken out, the stent was vacuum-dried at 40° C. to remove the solvent, and the irbesartan drug-coated stent adsorbed by porous silica gel ceramics was prepared.
Embodiment 3
[0058]Embodiment 3: As shown in Figure 3, a porous adsorbed drug-coated stent, the surface of the stent 4 is coated with a polymer coating 6 with micropores 5, and the drug is absorbed on the polymer coating 6 by dip coating of microwell 5. Specifically: add 10g of tetraethyl orthosilicate (TEOS) to 10g of water, then add 0.1g of HCL, mix and disperse evenly at 40°C, form a sol in 2 hours, then spray on the surface of the stent, and then place the stent in an oven at 80°C , cured for 24 hours, and then dried at 250-800°C to densify it to form a porous silica gel ceramic-coated scaffold. Then immerse the stent in a methanol solution of Candesartan (Candesartan) with a concentration of 1%-60% for 1min-60min. After the stent is taken out, the solvent is removed by vacuum drying at 40° C., and the candesartan drug-coated stent adsorbed by porous silica gel ceramics is prepared.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com