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Complex bone cement

A bone cement and composite technology, applied in the field of bone cement, can solve the problems such as side effects caused by fluctuation of drug concentration and inconvenient operation, and achieve the effects of inhibiting bone erosion, improving efficiency and high biological activity.

Inactive Publication Date: 2014-03-26
FAR EASTERN MEMORIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Clinically, calcistatin is usually administered by intramuscular injection. This method is not only inconvenient to operate, but also the concentration fluctuation of the drug in the blood is more likely to cause side effects

Method used

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  • Complex bone cement
  • Complex bone cement
  • Complex bone cement

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Embodiment Construction

[0053] The "Composite Bone Cement" in this case will let those skilled in the art understand its creative spirit through the description of the following examples, and can complete it accordingly. The implementation of this case is not limited by the following implementation modes.

[0054] In order to confirm that the bone cement composition proposed by the present invention has osteoinductive ability and other favorable properties, experiments were carried out on the physical properties of bone cement, such as setting time, mechanical strength, porosity, crystal structure, water absorption, and degradation rate in vitro. confirm. The release rate of calcistatin in bone cement and the effect of its extract on the osteosclerotic differentiation of stem cells were also discussed. Finally, animal experiments were carried out, and the bone cement without calcistatin and calcistatin were implanted into the bone defect at the same time, and the bone tissue was taken out after a ce...

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Abstract

The present application provides a complex bone cement including a powder mixture and an aqueous solution. The powder mixture includes calcium sulfate and a calcium phosphate salt. The aqueous solution includes water, collagen and a pharmaceutical ingredient in effective dose. By adding collagen and the pharmaceutical ingredient to the aqueous solution of the bone cement, the drug will release in a long-acting manner and induce differentiation of osteoblast as well as the healing of bone defects.

Description

technical field [0001] The invention relates to a bone cement, especially a composite bone cement which can be used as a carrier of medical components. Background technique [0002] Clinically, common bone defects caused by trauma or tumor removal, as well as the loss of bone matrix caused by osteoporosis, will cause the bones to lose their supporting strength, thereby affecting the daily life of patients. In order to solve the above problems, bone filling materials have been developed for implanting bone defects to speed up bone tissue repair and restore the normal function of healthy bone tissue. [0003] A good bone substitute should be osteoconductive, osteoinductive, biocompatible, bioabsorbable, structurally similar to bone tissue, easy to use, and inexpensive. Ceramic materials composed of calcium salts have been used in dentistry and orthopedics since the 1980s, and their good biocompatibility and mechanical properties are their main advantages. Calcium salts that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/42A61L27/24A61L27/12
Inventor 张至宏许元铭方旭伟
Owner FAR EASTERN MEMORIAL HOSPITAL
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