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Curcumin solid lipid nanoparticle with P-gp inhibiting effect and preparation method thereof

A solid lipid nanometer and inhibition technology, which is applied in the directions of non-active ingredients such as medical preparations, pharmaceutical formulations, ketone active ingredients, etc. Effect

Inactive Publication Date: 2014-03-26
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key to solving this problem at present is to adopt P-gp inhibitors, commonly used inhibitors such as ketoconazole have certain side effects in clinic

Method used

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  • Curcumin solid lipid nanoparticle with P-gp inhibiting effect and preparation method thereof
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  • Curcumin solid lipid nanoparticle with P-gp inhibiting effect and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1 curcumin solid lipid nanoparticle and preparation method thereof

[0034] Curcumin 10mg, Glyceryl Monostearate 60mg, Soy Lecithin 90mg, Brij 7890mg, TPGS 60mg, Distilled Water 15mL;

[0035] The method for preparing above-mentioned curcumin solid lipid nanoparticles:

[0036] (1) Weigh Brij78 and TPGS, add distilled water and ultrasonically disperse until completely dissolved to form an aqueous phase; weigh curcumin, glyceryl monostearate, and soybean lecithin, and dissolve them in the organic phase at a temperature of 75-80°C to form an organic phase. phase solution;

[0037] (2) Heat the water phase and the oil phase in a water bath to 75-80°C respectively, then add the oil phase dropwise into the water phase under constant temperature magnetic stirring at a stirring speed of 1000 rpm, and keep stirring at a constant temperature for 20 minutes to remove the organic solvent to obtain colostrum;

[0038] (3) Place the prepared colostrum in an ice-water ba...

Embodiment 2

[0040] Embodiment 2 curcumin solid lipid nanoparticles and preparation method thereof

[0041] Curcumin 10mg, Glyceryl Monostearate 60mg, Soy Lecithin 90mg, Brij 5890mg, TPGS 60mg, Distilled Water 15mL;

[0042] The method for preparing above-mentioned curcumin solid lipid nanoparticles:

[0043] (1) Weigh Brij58 and TPGS, add distilled water and ultrasonically disperse until completely dissolved to form an aqueous phase; weigh curcumin, glyceryl monostearate, and soybean lecithin, and dissolve them in the organic phase at a temperature of 75-80°C to form an organic phase. phase solution;

[0044] (2) Heat the water phase and the oil phase in a water bath to 75-80°C respectively, then add the oil phase dropwise into the water phase under constant temperature magnetic stirring at a stirring speed of 1200 rpm, and keep stirring at a constant temperature for 20 minutes to remove the organic solvent to obtain colostrum;

[0045](3) Place the prepared colostrum in an ice-water ba...

Embodiment 3

[0047] Embodiment 3 curcumin solid lipid nanoparticles and preparation method thereof

[0048] Curcumin 10mg, Glyceryl Monostearate 60mg, Soy Lecithin 90mg, Brij 3890mg, TPGS 60mg, Distilled Water 15mL;

[0049] The method for preparing above-mentioned curcumin solid lipid nanoparticles:

[0050] (1) Weigh Brij38 and TPGS, add distilled water and ultrasonically disperse until they are completely dissolved to form an aqueous phase; weigh curcumin, glyceryl monostearate, and soybean lecithin, and dissolve them in the organic phase at a temperature of 75-80°C to form an organic phase. phase solution;

[0051] (2) Heat the water phase and the oil phase in a water bath to 75-80°C respectively, then add the oil phase dropwise into the water phase under constant temperature magnetic stirring, the stirring speed is 1500rpm, and keep stirring at constant temperature for 20min to remove the organic solvent to obtain colostrum;

[0052] (3) Place the prepared colostrum in an ice-water ...

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Abstract

The invention relates to a curcumin solid lipid nanoparticle with a P-gp inhibiting effect, and a preparation method and application thereof. The curcumin solid lipid nanoparticle comprises the following components according to mass ratio: 0.05-1% of curcumin, 5-15% of lipid material, 5-15% of an emulgator and the balance of water. According to the invention, the solid lipid nanoparticle technology is adopted to encapsulate curcumin, so that the stability of medicine is increased, the solubility of medicine is improved, the excretion function of small intestines is reduced, and the bioavailability of curcumin is improved. In addition, the preparation method of the curcumin solid lipid nanoparticle, disclosed by the invention, is the emulsification evaporation and low temperature solidification method which is simple and convenient and suitable for being used in a laboratory, and has low requirements for an apparatus.

Description

technical field [0001] The invention belongs to the field of nanometer traditional Chinese medicine preparations, in particular to a solid lipid nanoparticle preparation of traditional Chinese medicine curcumin with P-gp inhibitory effect and a preparation method thereof. Background technique [0002] Curcumin is an orange-yellow crystalline powder extracted from turmeric. Curcumin has a diketone structure and is a polyphenolic compound. In recent years, studies have found that it has a wide range of pharmacological activities, such as anti-inflammatory and anti-oxidation, anti-tumor, anti-hyperlipidemia, etc., especially in the prevention and treatment of tumors. A large number of studies have shown that curcumin has an inhibitory effect on a variety of tumor cells, such as: breast cancer, prostate cancer, skin cancer, lymphoma and leukemia. In addition, curcumin has very little toxic and side effects on rodents and humans, and even at very high doses, there is no obvious...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/12A61K47/34A61K47/24A61P29/00A61P39/06A61P35/00A61P3/06
Inventor 纪宏宇李梦婷吴琳华唐景玲崔超任金妹
Owner HARBIN MEDICAL UNIVERSITY
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