Animal sleep deprivation device and application thereof

Abstract

The invention relates to an animal sleep deprivation device and application of the animal sleep deprivation device. The animal sleep deprivation device is provided with a stimulation occurrence base plate and a multi-lead program control instrument. The stimulation occurrence base plate is sequentially provided with a sieve plate, a stimulation plate and a supporting plate from top to bottom. The sieve plate is provided with sieve holes. The upper end face of the stimulation plate is provided with stimulation columns which correspond to the sieve holes in position and can penetrate through the sieve holes. A mechanical power device is arranged between the stimulation plate and the supporting plate, and is connected with the multi-lead program control instrument through a guide line. The multi-lead program control instrument is provided with a switch key, a guide line interface and a parameter adjusting panel. When the animal sleep deprivation device is used for building an insomnic animal model, no harmful stimulation is produced on experimental animals, experimental results are more accurate and reliable, the repeatability is good, multiple insomnia models can be obtained, and operation is convenient. The animal sleep deprivation device is simple in structure and low in cost.

Description

technical field [0001] The invention relates to an animal experiment device, in particular to an animal sleep deprivation device and its application. Background technique [0002] Insomnia is a common clinical disease and problem that plagues modern people. According to reports, about 30% of adults in the world suffer from insomnia, and 20%-30% in my country, of which 1 / 3 is severe insomnia. Therefore, the research and prevention of insomnia is imminent. [0003] In biomedical research, we often rely on the use of animal models to verify experimental hypotheses and clinical hypotheses, in order to more effectively understand the occurrence and development of human diseases, and study prevention and treatment measures. Therefore, the use of animal models has become an extremely important experimental method and means in modern biomedical research, and rats and mice are currently the most commonly used experimental animals, accounting for more than 90% of experimental animals....

AI Technical Summary

Problems solved by technology

The obvious disadvantage of this device is that the animals are subjected to a series of stimuli such as isolation, braking, and immersion in water, and can only be used to deprive REM sleep; ground movement, making it impossible to fall asleep, the more representative ones are the horizontal turntable sleep deprivation method and the intermittent treadmill deprivation method

The disadvantage of this device is that the experimental device is complicated, and the animal is subject to a series of reactions caused by long-term exercise; 3) The drug model achieves the purpose of insomnia through drug administration, but the disadvantage is that the drug has obvious toxic and side effects, and the long-term drug administration has a large manual workload; 4) Stimulation, using tactile, sound, or light stimulation to keep animals from falling asleep, can encourage rats to stay awake by gently tapping the rat cage or using sound stimulation

The disadvantage of this type of device is that the parallel repeatability of the experiment is poor, and the manual workload is too large, making it difficult to build a chronic model

[0005] In summary, there is an urgent need for an animal body that suffers less adverse stimuli, can obtain a more accurate sleep deprivation model, has little impact on experimental results, and can construct a variety of insomnia animal models, and has a simple structure and an easy-to-operate device and method , but there are no reports on such devices and methods

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