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Functionalized mesoporous bioglass porous scaffolds as well as preparation method and application thereof

A bioglass and porous scaffold technology, applied in medical science, prosthesis, etc., can solve problems such as limited bone repair ability, mesoporous structure damage, and small load capacity, and achieve enhanced hydrophilicity, enhanced adsorption, and increased load capacity Effect

Active Publication Date: 2014-03-12
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] The purpose of the present invention is to provide a functionalized mesoporous bioglass porous scaffold and its preparation method and application, thereby solving the problem that the mesoporous bioglass porous scaffold in the prior art has low strength, low porosity, and destroyed mesoporous structure. And the defects of small loading capacity and limited bone repair ability

Method used

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  • Functionalized mesoporous bioglass porous scaffolds as well as preparation method and application thereof
  • Functionalized mesoporous bioglass porous scaffolds as well as preparation method and application thereof
  • Functionalized mesoporous bioglass porous scaffolds as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033](1) Add 4g P123 (a three-block copolymer, full name: polyethylene oxide-polypropylene oxide-polyethylene oxide three-block copolymer, its molecular formula is: PEO-PPO-PEO) , 6.7g ethyl orthosilicate, 1.4g Ca(NO 3 ) 2 4H 2 O, 0.73g of triethyl phosphate and 1.0g of 0.5M hydrochloric acid were added to 60.0g of absolute ethanol, stirred at 30°C for 18h to form a transparent sol, and the obtained sol was placed in a petri dish and volatilized at 27°C for 48h to form gel, and then roast the obtained gel in a muffle furnace at 600°C for 5 hours, take it out and grind it to obtain mesoporous bioglass powder;

[0034] (2) Mix 0.3g of mesoporous bioglass powder, 0.05g of polyvinylpyrrolidone powder and 0.3g of polyethylene glycol particles evenly, put them into a cylindrical steel mold with a diameter of 0.5cm, and press them under a pressure of 3MPa. The formed mesoporous bioglass was put into a muffle furnace at 500° C. for 6 hours and fired for 6 hours to obtain a cylindr...

Embodiment 2

[0041] (1) Mix 4g P123, 7.5g tetraethyl orthosilicate, 0.5g Ca(NO 3 ) 2 4H 2 O, 0.73g of triethyl phosphate and 1.0g of 0.5M hydrochloric acid were added to 60.0g of absolute ethanol, stirred at 28°C for 24h to form a transparent sol, and the obtained sol was placed in a petri dish and volatilized at 25°C for 36h to form gel, and then roast the obtained gel in a muffle furnace at 500°C for 5 hours, take it out and grind it to obtain mesoporous bioglass powder;

[0042] (2) Mix 0.4g of mesoporous bioglass powder, 0.1g of polyvinylpyrrolidone powder and 0.4g of polyethylene glycol particles evenly, put it into a cylindrical steel mold with a diameter of 1cm, and press it under a pressure of 4MPa. The shaped mesoporous bioglass was placed in a muffle furnace at 600°C for 5 h and fired to obtain a cylindrical mesoporous bioglass scaffold MBG-SCA with a diameter of 1 cm and a thickness of 0.3 cm.

[0043] Such as figure 1 As shown in B in , it can be roughly observed that there...

Embodiment 3

[0045] (1) Mix 8g P123, 5.8g tetraethyl orthosilicate, 2.4g Ca(NO 3 ) 2 4H 2 O, 0.73g of triethyl phosphate and 1.0g of 0.5M hydrochloric acid were added to 60.0g of absolute ethanol, stirred at 32°C for 12h to form a transparent sol, and the obtained sol was placed in a petri dish and volatilized at 30°C for 72h to form gel, and then roast the obtained gel in a muffle furnace at 700°C for 5 hours, take it out and grind it to obtain mesoporous bioglass powder;

[0046] (2) Mix 0.5g of mesoporous bioglass powder, 0.15g of polyvinylpyrrolidone powder and 0.5g of polyethylene glycol particles evenly, put it into a cylindrical steel mold with a diameter of 1.5cm, and press it under a pressure of 5MPa. The shaped mesoporous bioglass was put into a muffle furnace at 700°C for 4 hours and fired for 4 hours to obtain a cylindrical mesoporous bioglass scaffold MBG-SCA with a diameter of 1.5 cm and a thickness of 0.3 cm.

[0047] Such as figure 1 As shown in C in , it can be roughly...

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Abstract

The invention provides functionalized mesoporous bioglass porous scaffolds as well as a preparation method and an application thereof. The preparation method comprises the following steps: (1) providing mesoporous bioglass powder; (2) uniformly mixing the mesoporous bioglass powder, a binding agent and a pore-foaming agent in a mass ratio of (0.3-0.5): (0.05-0.15): (0.3-0.5) so as to obtain mixed powder, putting the mixed powder into a mold, and pressing at the pressure of 2-5 Mpa; (3) putting and baking materials obtained by pressing in a muffle furnace so as to obtain porous scaffolds; (4) respectively putting the scaffolds into a methylbenzene solution containing a silane coupling agent APS (aminopropyltriethoxysilane) and a methylbenzene solution containing 3-(triethoxysilyl)propylsuccinic anhydride (TESPSA), refluxing, and drying in a vacuum so as to respectively obtain the amination mesoporous bioglass porous scaffold and the carboxylation mesoporous bioglass porous scaffold. The porous scaffolds provided by the invention have the advantages that the mesoporous structure of mesoporous bioglass is maintained, and the porous scaffolds are relatively high in porosity and large in capacity, have relatively high strength and can be used for bone tissue repairing.

Description

technical field [0001] The present invention relates to the field of nanometer and biomaterials, and more specifically relates to a functionalized mesoporous biological glass porous support and its preparation method and application. Background technique [0002] Bone tissue damage caused by diseases, trauma, and population aging seriously endangers human health, and there is a huge demand for bone tissue repair materials. Therefore, it is urgent to develop efficient bone tissue repair materials. [0003] Bone tissue repair materials are divided into metal materials, inorganic non-metal materials and polymer materials according to the type of materials. Among them, inorganic non-metallic materials have been widely used because of their good biocompatibility and good bonding with tissues, among which bioactive glass is the most widely used. [0004] In 1971, Hench et al. (Hench LL, Splinter RJ, Allen WC, Greenlee TK.J Biomed Mater Res. 1971, 2, 117) used the fusion method to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/12
Inventor 李永生张兴棣李楠施剑林
Owner EAST CHINA UNIV OF SCI & TECH
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