Preparing method of compound brucea javanicaseed oil liposome freeze-dried powder

Abstract

The invention provides a preparing method of a compound brucea javanicaseed oil liposome freeze-dried powder, and belongs to the technical field of traditional Chinese medicine preparation. The preparing method is characterized by comprising the following steps: 1) weighing soybean phospholipids, cholesterol, vitamin E and brucea javanicaseed oil, dissolving by ethanol, and taking as an oil phase; 2) measuring a toad venom aqueous extract, adding mannitol and sucrose, and adding distilled water to as an aqueous phase; 3) injecting the oil phase into the aqueous phase, and extruding by a micropore filter membrane to obtain a suspension; 4) filling a penicillin bottle with the suspension, carrying out freeze drying, and thus obtaining the compound brucea javanicaseed oil liposome freeze-dried powder. The preparation method of the compound brucea javanicaseed oil liposome freeze-dried powder adopts the brucea javanicaseed oil and toad venom for combined application, the average encapsulation rate of the prepared liposome freeze-dried powder is 91.90%, the average content of indole alkaloids is 5.19*10<-3> mg.g<-1>, the average content of oleic acid is 79.08 mg.g<-1>, the average content of linoleic acid is 50.41 mg.g<-1>, the antitumor effect is good, and toxic and side effects are small.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of compound brucea javanica oil liposome freeze-dried powder. Background technique [0002] With the change of economy and life structure, the morbidity and mortality of cancer have been continuously rising. Therefore, the research and development of anticancer drugs has become an urgent worldwide issue. Modern medicine has developed rapidly in the diagnosis and pathogenesis of malignant tumors, but the treatment methods have shown limitations. After more than half a century of continuous development and improvement, chemotherapy has become one of the important means of comprehensive treatment of malignant tumors. However, the curative effect of chemotherapy has always been at a low level. The reason is that the amount of chemotherapy drugs is large, most of which lack specific pharmacological activity, have extensive an...

AI Technical Summary

Problems solved by technology

However, the curative effect of chemotherapy has always been at a low level. The reason is that the amount of chemotherapy drugs is large, most of which lack specific pharmacological activity, have extensive and strong cytotoxicity, and have serious side effects on cancer tissues and normal tissues. Prone to allergic reactions and multidrug resistance during medication