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Composition of active ingredients of rubia cordifolia as well as application of composition in medicines

A composition and active technology, applied in the field of madder active ingredient composition, can solve problems such as large side effects, high price, and restrictions on drug promotion

Active Publication Date: 2014-02-05
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, batyl alcohol, lexogen, Ruibai and other drugs are often used for treatment, but the curative effect is poor and the side effects are relatively large
Although the granulocyte colony factor used in recent years has a certain curative effect, it is expensive and has many side effects, which limits the promotion of the drug

Method used

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  • Composition of active ingredients of rubia cordifolia as well as application of composition in medicines
  • Composition of active ingredients of rubia cordifolia as well as application of composition in medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of extract extract: Take 10kg of dry roots or rhizomes of Rubia cordifolia L., add 6 times the amount of 95% ethanol to heat and reflux for extraction twice, each time for 2 hours, add 6 times the amount of 75% ethanol to the residue Heat and reflux for extraction twice, each time for 2h. The ethanol was combined to reflux the extracts, and the ethanol was recovered under reduced pressure to obtain 1285.6 g of extract.

Embodiment 2

[0046]Preparation of extract extract: Take 10kg of dried root or rhizome of Rubia cordifolia L., add 8 times the amount of water to decoct twice for 2 hours each time, add 8 times the amount of 95% ethanol to the residue and heat and reflux to extract 2 times, 2 hours each time. Combine the water decoction and the ethanol reflux extract, and recover the ethanol under reduced pressure to obtain 1497.2 g of extract.

Embodiment 3

[0048] Preparation of 1,3,6-trihydroxy-2-methylanthraquinone-3-O-α-rhamnose (1→2)-β-glucoside: Weigh 200 g of the extract from Example 1 and add 10 times A certain amount of n-butanol was shaken and extracted 3 times, the extracts were combined, and n-butanol was recovered to obtain 62.7 g of extract. Put on a silica gel column (100g) and elute with dichloromethane, then dichloromethane-methanol (2:1), 200ml as a fraction, detect by HPLC, collect fractions 65-169, and depressurize The eluent was recovered to obtain 2.4 g of yellow powder. According to the aforementioned purity determination method, it was identified as 1,3,6-trihydroxy-2-methylanthraquinone-3-O-α-rhamnose (1→2)-β-glucoside with a purity of 96.89%.

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Abstract

The invention relates to an active extract composition of rubia cordifolia with exact pharmacologic action. The composition is characterized by comprising 1, 3, 6-trihydroxyl-methyl anthraquinone-3-O-alpha-rhamnose (1->2)-beta-glucoside and mollugin, and the total content of the two active ingredients is greater than 90%. The weight ratio of the 1, 3, 6-trihydroxyl-methyl anthraquinone-3-O-alpha-rhamnose (1-2)-beta-glucoside to the mollugin in the composition is 1:(0.5-5). The invention further relates to an application of the active extract composition of rubia cordifolia in preparing medicines for treating leucopenia.

Description

technical field [0001] The invention relates to a madder active ingredient composition and its application in medicine. The composition contains 1,3,6-trihydroxy-methylanthraquinone-3-O-α-rhamnose (1→2)-β-glucoside and rubidin, and the total weight of the two active ingredients is The content is greater than 90%. The composition can be used to prepare oral preparations for treating leukopenia. Background technique [0002] Where the number of white blood cells in peripheral blood is continuously lower than 4×10 9 / L, collectively referred to as leukopenia. The main clinical manifestations are fatigue and dizziness, often accompanied by symptoms such as loss of appetite, limp limbs, insomnia and dreaminess, low-grade fever, palpitations, chills and backache. Leukopenia is a common blood disease, especially in elderly patients. It happens because chemotherapy destroys normal cells as well as cancer cells. According to the American Cancer Society survey, there were 1,529,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P7/00A61K31/352
Inventor 单鸣秋丁安伟张丽陈佩东曹雨诞于生包贝华
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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