A kind of Nimodipine/Ligustrazine dual-loaded PLGA nanoparticles and preparation method thereof
A dual-loaded drug and nanoparticle technology, which is applied in the direction of pharmaceutical formulations, drug combinations, and medical preparations of non-active ingredients, can solve the problems of normal cell or tissue toxicity, short drug half-life, and frequent drug administration, etc., to avoid Enhance liver first-pass effect, reduce toxic and side effects, and delay drug release
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[0019] 1. Apparatus and materials
[0020] 1.1 Instrument
[0021] UV-1700 ultraviolet spectrophotometer (Shimadzu Corporation, Japan); Agilent1200 high performance liquid chromatograph (Agilent Technologies, USA); 380ZLS laser particle size analyzer (Nico mp, USA); JEM-1200EX Transmission Electron Microscope (JEOL, Japan) ); Labconco freeze dryer (Labconco, USA); Mill-Q ultrapure water device (Millpore, USA); KQ5200DE CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); TGL-16B high-speed desktop centrifuge (Shanghai Anting Scientific Instrument Factory); CP225D Electronic Balance (Beijing Sartorius Scientific Instrument Co., Ltd.); Nitrogen Purging Device (Hangzhou Aosheng Instrument Co., Ltd.); Dialysis Bag (Shanghai Green Bird Technology Development Co., Ltd., Mw=14000Da); HZ-9212S water bath constant temperature oscillator (Jiangsu Taicang Hualida Experimental Equipment Company).
[0022] 1.2 Drugs and reagents
[0023] Nimodipine (Hubei Hengshuo Pharmaceutical Co....
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