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A kind of purification method of 3-hydroxybutanone

A technology of hydroxybutanone and purification method, which is applied in the separation/purification of carbonyl compounds, organic chemistry, etc., and can solve the problem of no concentration

Active Publication Date: 2016-06-08
SHANDONG LUBEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The object of the present invention is to provide a kind of processing method for separating and purifying 3-hydroxybutanone from biological fermentation liquid, which is characterized by the extraction process combining vacuum distillation and osmotic distillation, and solves the problem that simple vacuum distillation has no concentrating effect. problem, increasing the commercial value of 3-hydroxybutanone

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Embodiment 13

[0015] A kind of purification method of embodiment 13-hydroxybutanone, carry out successively according to the following steps:

[0016] 1. Distillation under reduced pressure of fermentation broth: Centrifuge 70L of fermentation broth containing 56.5g / L of 3-hydroxybutanone to remove bacteria, distill under reduced pressure at 90°C, recover the condensate, and measure the content of 3-hydroxybutanone to be 58.1 g / L.

[0017] 2. Osmotic distillation (OD) concentration: polyethylene hollow fiber membrane, CaCl 2 As extractant (salt solution), with CaCl 2 Solution - distilled water for saline solution system, CaCl 2 The concentration is 55% (W / W), the temperature of the salt solution and 3-hydroxybutanone distillate is 50° C., and the feed rate is 70 L / h.

[0018] After vacuum distillation and osmotic distillation, 58.6 L of distillate was finally obtained, the content of 3-hydroxybutanone was 62.3 g / L, the purification yield was 92.3%, and the product purity was 99.2%.

Embodiment 23

[0019] A kind of purification method of embodiment 23-hydroxybutanone, carry out successively according to the following steps:

[0020] 1. Distillation under reduced pressure of fermentation broth: Centrifuge 70L of fermentation broth containing 56.2g / L of 3-hydroxybutanone to remove bacteria, distill under reduced pressure at 80°C, recover the condensate, and measure the content of 3-hydroxybutanone to be 57.5 g / L.

[0021] 2. Osmotic distillation (OD) concentration: polyethylene hollow fiber membrane is used, NaCl is used as the extractant (salt solution), NaCl solution-distilled water is the salt solution system, the concentration of NaCl is 20% (W / W), the salt solution and The temperature of the 3-hydroxybutanone distillate was 55° C., and the feed rate was 60 L / h.

[0022] After vacuum distillation and osmotic distillation, 59.3 L of distillate was finally obtained, the content of 3-hydroxybutanone was 61.4 g / L, the purification yield was 92.6%, and the product purity w...

Embodiment 33

[0023] A kind of purification method of embodiment 33-hydroxybutanone, carry out successively according to the following steps:

[0024] 1. Distillation of fermentation broth under reduced pressure: Centrifuge 70L of fermentation broth containing 56.8g / L of 3-hydroxybutanone to remove bacteria, distill under reduced pressure at 90°C, recover the condensate, and measure the content of 3-hydroxybutanone to be 58.5 g / L.

[0025] 2. Osmotic distillation (OD) concentration: use polytetrafluoroethylene hollow fiber membrane, CaCl 2 As extractant (salt solution), with CaCl 2 Solution - distilled water for saline solution system, CaCl 2 The concentration is 50% (W / W), the temperature of the salt solution and 3-hydroxybutanone distillate is 45° C., and the feed rate is 65 L / h.

[0026] After vacuum distillation and osmotic distillation, 57.9 L of distillate was finally obtained, the content of 3-hydroxybutanone was 62.2 g / L, the purification yield was 90.6%, and the product purity w...

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Abstract

The invention relates to a purification method of 3-hydroxy butanone, and belongs to the technical field of industrial microorganisms. The method comprises the following steps: firstly, centrifuging a fermentation liquor to remove thallus, carrying out vacuum distillation, recovering condensate, and then carrying out osmotic distillation (OD) concentration on the condensate, wherein the purification yield can be up to over 90.0%; the purity of the 3-hydroxy butanone product can be up to over 98.0%. According to the purification method, the problem that no concentration action exists in pure vacuum distillation is solved by taking a technology of combining vacuum distillation with osmotic distillation as the characteristic; the commercial value of 3-hydroxy butanone is improved; the purification method has the advantages of being simple in technology, mild in conditions, friendly to environment, high in product purity, easy in extraction at a large scale, and the like.

Description

technical field [0001] The invention relates to a method for separating and purifying 3-hydroxybutanone from fermentation liquid, belonging to the technical field of industrial microbes. Background technique [0002] 3-Hydroxybutanone (acetoin), also known as acetoin and methyl acetylmethanol, is widely found in corn, grapes, cocoa, apples, bananas, malt, and animal tissues, and is also an intermediate metabolite of a variety of microbial sugar metabolism. 3-Hydroxybutanone is a main aroma substance produced during the process of fermenting milk by lactic acid bacteria. It has a unique creamy aroma and is mostly used as an aroma enhancer for cream, cheese, and coffee. As a flavoring agent, the American Food and Extraction Association ( FEMA) has been approved for use in food, and its safety number is 2008, and my country's GB2760-1996 has also clearly stipulated that it is allowed to be eaten. [0003] The molecular formula of 3-hydroxybutanone is C 4 h 8 o 2 , molecular ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/17C07C45/82C07C45/78
CPCC07C45/82C07C49/17
Inventor 王克柳王美海
Owner SHANDONG LUBEI PHARMA
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