Chinese patent medicine for treating Type II diabetic nephropathy and preparation method thereof

Abstract

The invention discloses a Chinese patent medicine for treating Type II diabetic nephropathy and a preparation method thereof. The Chinese patent medicine is prepared by the following raw materials in parts by weight: 15-35 parts of astragalus membranaceus, 10-15 parts of radix pseudostellariae, 12-15 parts of radix puerariae, 15-30 parts of semen coicis, 10-15 parts of radix rehmanniae, 12-15 parts of achyranthes root, 12-30 parts of serissa serissoide, 10-15 parts of winged euonymus twig, 12-15 parts of capparidaceae, 10-15 parts of rhizoma cyperi, 6-10 parts of rheum officinale, 6-10 parts of semen brassicae, and 2-6 parts of leech. The Chinese patent medicine for treating Type II diabetic nephropathy has effects of tonifying qi and yin, eliminating turbid fluid and dredging collaterals, and can be used for relieving the clinical symptoms of diabetic nephropathy patients, lowering fasting blood-glucose, creatinine and urea nitrogen, and improving the excretion rate of beta2-microglobulin and urine microalbumin, and the cystatin level, the total effective rate is 93.06%c, so that the Chinese patent medicine has reliable effect in treating diabetic nephropathy, has no obvious toxic and side effects, has high biological availability, and has good controllability and stability.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a Chinese patent medicine for treating type II diabetic nephropathy and a preparation method thereof. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN) is a severe complication of diabetes mainly caused by glomerular sclerosis, which is caused by diabetic microangiopathy and has become an important cause of end-stage renal failure and one of the leading causes of death in diabetes . The clinical manifestations are proteinuria, edema, hypertension and progressive damage of renal function. The main pathological manifestations of DN are glomerular hypertrophy, hyperplasia of extracellular matrix, widening of glomerular mesangial area and thickening of capillary basement membrane, and finally progress to glomerulosclerosis. Its pathogenesis involves genetics, glucose metabolism disorders, hemodynamic changes, cytokines, inflammatory ...

AI Technical Summary

Problems solved by technology

Although ACEI and ARB are the drugs of choice for the treatment of DN, when serum creatinine is greater than 265 μmol L -1 , it cannot be applied

Renal replacement therapy for end-stage renal failure, such as hemodialysis, peritoneal dialysis, kidney or combined pancreas-kidney transplantation, but there are problems such as high cost and poor patient compliance

In recent years, although there have been some Chinese patent medicines for the treatment of diabetes, such as Jiangtangning Capsules, Jinqi Jiangtang Tablets, Jiangtang Tongmai Tablets, etc., the above reports are some clinical trials, and even the combination of Chinese medicine and Western medicine has different effects. The repeatability is not good, and there are few basic experiments. At present, there is still a lack of Chinese patent medicines for the treatment of diabetic nephropathy.

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