Compound containing Lafutidine and preparation containing Lafutidine

A technology for lafutidine and a composition is applied in the field of lafutidine preparations, which can solve the problems of difficult absorption, poor water solubility of lafutidine, etc., and achieves excellent effect, low impurity content, and stable high temperature and high humidity conditions. Effect

Active Publication Date: 2013-12-04
YOUCARE PHARMA GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Experiments have confirmed that lafutidine has slightly poor water solubility. Although the currently marketed varieties are made into capsules, it is found that lafutidine is not easily absorbed by the human body because of its slightly poor water solubility.

Method used

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  • Compound containing Lafutidine and preparation containing Lafutidine
  • Compound containing Lafutidine and preparation containing Lafutidine
  • Compound containing Lafutidine and preparation containing Lafutidine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: lafutidine capsules

[0033] 1. Composition: Lafutidine 5kg, lactose 106kg, Tween-803kg, hydroxypropyl cellulose 4kg, talcum powder 55kg.

[0034] 2. Preparation method:

[0035] 1) Pulverize lafutidine, pass through a 100-mesh sieve, and set aside;

[0036] 2) Grind talcum powder, lactose, and hydroxypropyl cellulose separately, and pass through an 80-mesh sieve;

[0037]3) Weigh each component according to the composition, mix the main drug and auxiliary materials for 15-20 minutes by equal amount addition method, and fill 3# capsules.

Embodiment 2

[0038] Embodiment 2: lafutidine capsules

[0039] 1. Composition: Lafutidine 5kg, lactose 120kg, Tween-803kg, hydroxypropyl cellulose 5kg, talcum powder 60kg.

[0040] 2. Preparation method:

[0041] 1) Pulverize lafutidine, pass through a 100-mesh sieve, and set aside;

[0042] 2) Grind talcum powder, lactose, and hydroxypropyl cellulose separately, and pass through an 80-mesh sieve;

[0043] 3) Weigh each component according to the composition, mix the main drug and auxiliary materials for 15-20 minutes by equal amount addition method, and fill 3# capsules.

Embodiment 3

[0044] Embodiment 3: lafutidine capsules

[0045] 1. Composition: Lafutidine 5kg, lactose 85kg, Tween-802kg, hydroxypropyl cellulose 3kg, talc 50kg.

[0046] 2. Preparation method:

[0047] 1) Pulverize lafutidine, pass through a 100-mesh sieve, and set aside;

[0048] 2) Grind talcum powder, lactose, and hydroxypropyl cellulose separately, and pass through an 80-mesh sieve;

[0049] 3) Weigh each component according to the composition, mix the main drug and auxiliary materials for 15-20 minutes by equal amount addition method, and fill 3# capsules.

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Abstract

The invention relates to a compound containing Lafutidine and a preparation containing Lafutidine. The compound comprises Lafutidine, lactose, tween-80, hydroxypropyl cellulose and talcum powder. Compared with the prior art, the compound is evidently faster in capsule dissolution rate and low in impurity content. In addition, the results of various detection of the compound meet the specification.

Description

technical field [0001] The invention relates to the field of lafutidine preparations, in particular to a composition containing lafutidine and a preparation containing the same. Background technique [0002] Peptic ulcer is a common chronic and recurrent digestive system disease. It is the result of the invasive factors of the gastrointestinal mucosa exceeding the defense ability of the mucosa's own protective factors. Its incidence rate accounts for about 10% of the total population. Peptic ulcer can occur in any part of the gastrointestinal tract that is in contact with acidic gastric juice, and the main diseased sites are the stomach and duodenum, with an incidence rate of 98%, and the number of patients with duodenal ulcer is far greater in patients with gastric ulcer. [0003] The formation of peptic ulcers is related to the digestion of gastric acid and pepsin, as well as local mucosal damage (ulcer-causing) factors of the stomach and duodenum (including gastric acid,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/4545A61K47/26A61K47/38A61K47/04A61P1/04
Inventor 李琦杨磊
Owner YOUCARE PHARMA GROUP
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