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NK (Natural Killer) cell new technology for treating tumor

A technology of NK cells and tumor treatment, applied in the fields of basic medicine and tumor science, can solve the problems of cytotoxicity and large net activation

Inactive Publication Date: 2013-10-30
孙勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

When tumor cells are recognized by NK cells, the expression of HLA molecules on the surface of target cells is down-regulated, and the inhibitory receptors mainly bind to HLA molecules (such as HLA-Cw2, HLA-Cw4, HLA-Cw5, HLA-Cw6, KIR2DL1 receptors, Whereas HLA-Cw1, HLA-Cw3, HLA-Cw7, HLA-Cw8 bind KIR2DL2 and KIR2DL3 receptors), activating receptors bind only a few HLA molecules (HLA-C and HLA-E), resulting in a net activation Greater than inhibitory effect, NK cells produce cytotoxic effect on target cells

Method used

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Examples

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Embodiment Construction

[0006] This example specifically illustrates the new technology of NK cells for tumor treatment of the present invention. Let's take umbilical cord blood as an example. Umbilical cord blood is the umbilical cord tissue that connects the placenta and the fetus when the pregnant woman gives birth. The umbilical cord is cut off when the fetus is born. It contains a large number of umbilical cord blood stem cells. These cells contain a large number of NK cells and are used for tumor transplantation. The operating steps of the present invention are as follows:

[0007] (1) Umbilical cord blood stem cell expansion and culture, sign a healthy (HBsAg, HCV-Ab, TP-Ab, HIV1 / 2-Ab, CMV-IgM are negative) maternal umbilical cord and cord blood donation consent, in sterile conditions in the delivery room Obtain the maternal umbilical cord and cord blood, and process the umbilical cord and cord blood separately in the 100-level laminar flow hood in the GMP workshop within 36 hours. Cord bloo...

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Abstract

Hematopoietic stem cells of healthy volunteers are separated and purified in a 100 grade GMP (Good Manufacturing Practice) plant, and are induced to divide to NK cells under a special condition of culture. Qualified NK cells are put in storage or KIR-matched with HLA (Human Leukocyte Antigen) and KN cells of the patients. The qualified NK cells are intravenously infused to tumor patients to prevent recurrence and metastasis of cancer cells of the tumor patients. The hematopoietic stem cells used by the method have the advantages of abundant source, material object storage and the like, are free from toxic and side effects and adverse reaction for treating tumor, and remarkably improve the survival quality of the tumor patients.

Description

technical field [0001] The invention belongs to the third type of medical technology, in particular to a new technology of NK cells for tumor treatment, and relates to the fields of basic medicine and tumor science. Background technique [0002] Cancer has become the number one killer of human beings. According to statistics, there are about 12.7 million new cases and 760 deaths in the world every year, and the number is increasing year by year. Clinical treatment is mainly based on surgery, radiotherapy and chemotherapy, but although surgery and radiotherapy have a good effect on controlling the local lesions of the tumor, they are powerless in preventing the recurrence and metastasis of the tumor. [0003] The purpose of tumor immunotherapy is to stimulate or mobilize the body's immune system, enhance the anti-tumor immunity of the tumor microenvironment, and thus control and kill tumor cells. The combination of tumor immunotherapy and modern biological high-tech technolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/44A61K35/14A61P35/00C12N5/0783A61K35/17
Inventor 孙勇
Owner 孙勇
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