Method for synthesizing diaryl ether compounds
A technology for diaryl ethers and compounds, which is applied in the field of preparation of synthetic compounds, can solve the problems of harsh reaction conditions, many by-products, complicated preparation processes, etc., and achieves the effects of mild reaction conditions, improved selectivity and simple operation.
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specific Embodiment approach 1
[0034] Specific embodiment one: a kind of method for synthesizing diaryl ether compound described in this embodiment is specifically carried out according to the following steps:
[0035] 1. Preparation of crude diaryl ether compound: Add picolinic acid, cesium carbonate, sodium ascorbate, polyethylene glycol 400 and dimethyl sulfoxide to copper trifluoroacetate in sequence, and stir and mix for 10-20 minutes, then add phenol Classes and aryl iodides, and then heated from room temperature to 40-60°C under the protection of nitrogen, and reacted at a temperature of 40-60°C for 10h-18h to obtain crude diaryl ether compounds;
[0036] The mol ratio of described phenols and aryl iodide is 1:(1~1.5); The mol ratio of described copper trifluoroacetate and phenols is 1:(5~15); Described picolinic acid and The mol ratio of phenols is 1:(3~8); The mol ratio of described cesium carbonate and phenols is (1.5~2.5):1; The mol ratio of described sodium ascorbate and phenols is 1:(4 ~8); th...
specific Embodiment approach 2
[0043] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the phenols described in step one are phenol, o-cresol, m-cresol, p-cresol, o-methoxyphenol, m-cresol Methoxyphenol or p-methoxyphenol. Others are the same as in the first embodiment.
specific Embodiment approach 3
[0044] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the aryl iodide described in step 1 is iodobenzene, m-chloroiodobenzene, p-chloroiodobenzene or p-bromoiodobenzene. Others are the same as in the first or second embodiment.
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