Method for modifying function gelatin

A technology for modifying gelatin, which is applied in the field of functional gelatin modification, which can solve the problems of gelatin becoming brittle and unfavorable for capsule storage and transportation, and achieve the effects of controllable hydrolysis degree, long-term preservation, and abundant raw material sources

Inactive Publication Date: 2013-09-25
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the cross-linking modification of gelatin capsules by aldehydes, due to the residual aldehydes and other problems, the gelatin will become brittle, which is not conducive to the storage and transportation of capsules; and fatty acid modifiers are more used as plasticizers. Function, the modified gelatin is mostly used to make membrane materials

Method used

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  • Method for modifying function gelatin
  • Method for modifying function gelatin
  • Method for modifying function gelatin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The method for functional gelatin modification, it comprises the following steps:

[0037] 1) Hydroxyl protection of 3,4-dihydroxybenzoic acid: Take a 250mL round bottom flask, add 50g of 3,4-dihydroxybenzoic acid and 150mL of acetone, put it in a water bath at 40°C and stir until dissolved, then add acetic anhydride 60mL, reflux reaction at 60°C for 3h, after the reaction is complete, distill and separate the solvent acetone at 65°C, the obtained product is taken out and dried for use;

[0038] 2) Acyl chloride of 3,4-dihydroxybenzoic acid: Take a 250mL round-bottomed flask, add the product in step 1), stir and disperse with 180mL chloroform for 1h, add 23.5mL of thionyl chloride, and reflux at 65°C for 3h , the tail gas is absorbed with an appropriate amount of NaOH solution. After the reaction is complete, the solvent chloroform is separated by distillation at 70°C. The obtained product is taken out, dried, and ground into powder for use;

[0039] 3) Modification of...

Embodiment 2

[0042] The method for functional gelatin modification, it comprises the following steps:

[0043] 1) Hydroxyl protection of 3,4-dihydroxybenzoic acid: take a 250mL round bottom flask, add 50g of 3,4-dihydroxybenzoic acid and 180mL of acetone, put it in a water bath at 40°C and stir until dissolved, then add acetic anhydride 90mL, reflux reaction at 65°C for 6h, after the reflux reaction is completed, distill and separate the solvent acetone at 70°C, the obtained product is taken out and dried for use;

[0044] 2) Acyl chloride of 3,4-dihydroxybenzoic acid: Take a 250mL round-bottomed flask, add the product in step 1), stir and disperse with 150mL chloroform for 2h, add 35mL of thionyl chloride, reflux at 70°C for 6h, The tail gas is absorbed with an appropriate amount of NaOH solution. After the reflux reaction is completed, the solvent chloroform is separated by distillation at 75°C. The obtained product is taken out, dried, and ground into powder for use;

[0045] 3) Modifi...

Embodiment 3

[0048] The method for functional gelatin modification, it comprises the following steps:

[0049] 1) Hydroxyl protection of 3,4-dihydroxybenzoic acid: Take a 250mL round bottom flask, add 50g of 3,4-dihydroxybenzoic acid and 160mL of acetone, put it in a water bath at 40°C and stir until dissolved, then add acetic anhydride 75mL, reflux reaction at 70°C for 4h, after the reflux reaction is completed, the solvent acetone is separated by distillation at 60°C, and the obtained product is taken out and dried for use;

[0050] 2) Acyl chloride of 3,4-dihydroxybenzoic acid: take a 250mL round bottom flask, add the product in step 1), stir and disperse with 150mL chloroform for 1.5h, add thionyl chloride 30mL, reflux at 75°C for 5h , the tail gas is absorbed with an appropriate amount of NaOH solution. After the reflux reaction is completed, the solvent chloroform is separated by distillation at 65°C. The obtained product is taken out, dried, and ground into powder for use;

[0051]...

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Abstract

The invention relates to a method for modifying function gelatin. The method comprises steps of: (1) mixing and stirring 3,4-dihydroxybenzoic acid and an solvent (acetone) until the 3,4-dihydroxybenzoic acid is dissolved, adding acetic anhydride to carry out a reflux reaction, and separating the solvent here; (2) stirring and dispersing the product of the step (1) by trichloromethane, adding thionyl chloride to carry out a reflux reaction, and separating the solvent here, wherein the product here is a modifier; (3) heating swelling gelatin until the gelatin turns into a fusion state, adjusting the pH of the gelatin solution to an alkalescence condition by a NaOH solution, uniformly adding the modifier of the step (2) to the gelatin solution at the same time, and carrying out a reaction with stiring; and (4) precipitating the modified function gelatin solution by a sulfur acid solution, washing and fusing, adjusting the pH to 6.0-7.0, and freeze drying the solution here to obtain modified function gelatin. The gelatin modified by a 3,4-dihydroxybenzoic acid modifier provided by the invention is characterized in that, isoelectric points of the gelatin decrease to pH of 1.7-2.1, the gelatin forms a precipitate state in an artificial gastric juice with no disintegration, and the color presents uniform milk white or light red.

Description

technical field [0001] The invention relates to a method for modifying functional gelatin, which belongs to the field of functional gelatin materials. Background technique [0002] As a natural biodegradable, non-toxic and non-polluting polymer biomaterial, gelatin has attracted the attention of many scholars in recent years. Gelatin is a degradation product of collagen. It is composed of 20 common amino acids. It has many excellent physical and chemical properties. It has strong hydrophilicity and the ability to form jelly. The chain group has high reactivity, and the ampholyte properties that the charge changes with the change of the pH value of the medium, etc. Gelatin is rich in sources, but pure gelatin has disadvantages such as brittle texture after drying, poor ductility, poor forming ability, and poor water and acid resistance. Taking the rich functional groups on amino acid residues in gelatin molecules as a breakthrough, gelatin is usually modified and applied to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08H1/00
Inventor 刘善堂刘闯彭必先
Owner WUHAN INSTITUTE OF TECHNOLOGY
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