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Compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury and preparation method

A technology of lipopolysaccharide selenate and radiation damage, which is applied in the direction of medical preparations containing active ingredients, ointment delivery, and pharmaceutical formulations, can solve the problems of difficult skin healing, unsmooth treatment, and skin burns of patients, and is easy to promote , easy to make, strong applicability

Inactive Publication Date: 2013-09-18
秦小林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Cause radiation damage, the damage of radiation to normal tissue cells and tumor tissue cells is divided into direct and indirect effects, of which free radicals account for 70%. Skin damage at the irradiation site is inevitable in tumor radiation therapy, especially at high local doses. Electron beams and X-rays are used to treat skin burns, which are particularly serious. The dry and wet reaction of the patient's skin causes severe pain and difficult healing, which makes the treatment unable to proceed smoothly.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0019] The component of the compound lipopolysaccharide selenate emulsifiable cream of preventing and treating radiation injury is as follows:

[0020] Selenate lipopolysaccharide (calculated as selenium) 2.28g Vitamin E 100g

[0021] Urea 50g Stearic acid 150g

[0022] Lanolin 20g Liquid Paraffin 250g

[0023] Glycerin 50g Sodium Benzoate 1g

[0024] Triethanolamine 20g distilled water to make up to 1000g

[0025] The preparation method of the compound lipopolysaccharide selenate emulsifiable paste of preventing and treating radiation damage is as follows:

[0026] A. Melt stearic acid, lanolin and liquid paraffin into oil phase at 70°C, slowly add vitamin E;

[0027] B. Grind urea, sodium benzoate and glycerin into a fine paste in a mortar;

[0028] C. Stir and dissolve lipopolysaccharide selenate, triethanolamine and distilled water at a constant temperature to 70°C;

[0029] D. Slowly add B and A to C under constant stirring, and stir and cool to room temperature aft...

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PUM

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Abstract

The invention provides a compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury and a preparation method. The compound selenic acid lipopolysaccharide emulsifiable paste for preventing and treating radioactive injury takes selenic acid lipopolysaccharide as a main formula for improving the immunocompetence of skins and antioxidant ability, and is compounded with an external emulsifiable paste with vitamin E-assisted potentiation. The compound selenic acid lipopolysaccharide emulsifiable paste through verification of clinical results has protective effect on radioactive injury of skins, and vitamin E and selenic acid lipopolysaccharide have the antioxidant effect by adjusting the immune metabolism and enhancing the activity of GSH-PX (Glutathione Peroxidase). The compound selenic acid lipopolysaccharide emulsifiable paste provided by the invention has the advantages of simpleness in manufacturing, low cost, strong applicability, convenience in popularization and the like, and no adverse reactions appear in clinical use.

Description

technical field [0001] The invention relates to a compound lipopolysaccharide selenate cream for preventing and treating radiation damage and its preparation, and belongs to the technical field of medicine and health care products. Background technique [0002] Vitamin E is a fat-soluble vitamin with 8 forms. It is an important antioxidant and has antioxidant properties. Selenate lipopolysaccharides can enhance the body's immune response and antioxidant capacity. These have been reported in the literature; selenate lipids Polysaccharides can scavenge free radicals in the body and enhance the degradation of oxides to protect the human body from the carcinogenic effect of ultraviolet rays. Radiotherapy is one of the main treatment methods for malignant tumors. Normal skin at the site irradiated during radiation therapy is easily [0003] Cause radiation damage, the damage of radiation to normal tissue cells and tumor tissue cells is divided into direct and indirect effects, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/739A61K9/06A61P17/16A61P37/04A61K31/355
Inventor 秦小林
Owner 秦小林
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