Micro-fluidic serum extracting chip

Abstract

The invention aims to provide a micro-fluidic serum extracting chip. The chip is formed by a blood sample introduction pool, a micro channel, a serum separation chamber and a sample collecting pool, wherein the interior of the serum separation chamber is filled with two kinds of micro balls with different hole diameters. The operating principle of the chip is as follows: the whole blood is added from a sample introduction port, the blood sample flows through the serum separation chamber along the micro channel under the action of surface tension or certain negative pressure, hemocytes are intercepted by a micro ball structure, and the serum flows out from ventages among the micro balls, and finally enters the sample collecting pool. The chip provided by the invention can be used for rapidly extracting the serum on line, the operation is simple and convenient, the separation efficiency is high, and the further integration with other operation units is easy to realize.

Description

technical field [0001] The invention relates to a microfluidic chip, in particular to a serum extraction chip. Background technique [0002] Biochemical medical testing based on human body fluids such as blood, urine and saliva can provide important information that reflects people's health status. At present, blood testing is the most widely used sample testing in biomedicine, clinical diagnosis, health and quarantine diagnosis, but the presence of red blood cells has a great interference on the spectral analysis in blood testing, so how to quickly and easily separate serum from whole blood It has always been a hot and difficult issue in blood testing research. [0003] At present, most hospitals and laboratories still use large centrifuges to separate serum and blood cells. This method requires blood samples in milliliters to be drawn from patients, but the samples actually used for testing are only tens or even several microliters, resulting in A large amount of waste; ...

AI Technical Summary

Problems solved by technology

At present, blood testing is the most widely used sample testing in biomedicine, clinical diagnosis, health and quarantine diagnosis, but the presence of red blood cells has a great interference on the spectral analysis in blood testing, so how to quickly and easily separate serum from whole blood It has always been a hot and difficult issue in blood testing research

[0003] At present, most hospitals and laboratories still use large centrifuges to separate serum and blood cells. This method requires blood samples in milliliters to be drawn from patients, but the samples actually used for testing are only tens or even several microliters, resulting in A large amount of waste; and this kind of centrifuge equipment is large in size and complex in mechanical structure. The serum separation process and detection are carried out separately and independently, which is easy to cause the loss and contamination of blood samples. It is not suitable for the integration of clinical diagnosis and micro-analysis systems, and cannot meet medical The need for the development of micro-analysis system in diagnosis, so it is necessary to develop a new micro-separation technology

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