Synthesis method for 2-arylbenzofuran and derivative thereof
A derivative, arylbenzene technology, applied in the field of organic synthesis, can solve the problems of expensive catalyst, poor substrate adaptability, difficult raw material preparation, etc. Effect
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Embodiment 1
[0052] This example describes the synthesis test carried out in the reaction system A and in the preferred mode of staged temperature rise.
[0053] The reaction system includes: raw material (1 mmol), inorganic base, copper catalyst, ligand, and reaction medium. Raw material: inorganic base: copper catalyst: ligand: reaction medium=1:3:(0.1~10):0.15:5.
[0054] The raw materials specifically relate to 3-aryl coumarin and its derivatives a1-a10.
[0055] Reaction process: Add the reaction system to the reaction bottle, and add crushed molecular sieves (6 4A molecular sieves) at the same time, connect the drying tube; place the reaction bottle at a temperature of W°C and stir for X hours, then raise the temperature to a temperature of Y°C, and react for Z hours . Keep the system open to the atmosphere during the reaction process.
[0056] Extraction of the crude product: After the reaction, the reaction solution was adjusted to pH=2.0 with hydrochloric acid (6mol / L), extract...
Embodiment 2
[0062] This example describes the synthesis test carried out in the preferred mode of staged temperature rise with the reaction system B.
[0063] The reaction system includes: raw material (1 mmol), copper hydroxide or / and cuprous hydroxide, ligand, and reaction medium. Raw material: copper hydroxide or / and cuprous hydroxide: ligand: reaction medium=1: (2~10): (0.15~10): (5~100).
[0064] Synthesis and product extraction and purification operations are the same as in Example 1.
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