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Multi-functional ionic liquid compositions

一种离子液体、离子的技术，应用在药物组合、杂环化合物有效成分、重金属化合物有效成分等方向，能够解决溶解度低、难制剂、低生物利用度等问题

Inactive Publication Date: 2013-09-04
UNIVERSITY OF ALABAMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Another common problem with many drugs is low solubility
Low solubility can make certain compounds difficult to formulate, and often low solubility means low bioavailability

Method used

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  • Multi-functional ionic liquid compositions
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  • Multi-functional ionic liquid compositions

Examples

Experimental program
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specific example

[1001] The disclosed ionic liquid compositions may also include energetic components as well as explosive species. The ability to prepare specific compositions with high energy content substituents on one ion (fuel) and high oxygen balance on the other (oxidant) has led to widespread applications in today's high energy compound industry. The ability to independently form ionic groups of different functionalizations, then select two desired ones and combine them as needed to form energetic species of desired strength (Scheme 1), opens up the rapid preparation of species with customizable energy (e.g., with Explosives of predetermined power) and technologies for the safer storage of these energetic substances, since the components are separated prior to use. The disclosed compositions can be prepared according to one of the following reaction schemes.

[1002] Scenario 1: Route 1

[1003]

[1004] Wherein En is an energy functional group containing high oxygen or nitrogen c...

specific Embodiment approach

[1125] The following examples are given to illustrate the methods and results of the disclosed subject matter. These examples are not intended to cover all aspects of the subject matter disclosed herein, but are intended to illustrate representative methods and results. These examples are not intended to exclude equivalents and modifications of the invention which are obvious to those skilled in the art.

[1126]Efforts have been made to ensure accuracy with respect to data (eg, amounts, temperature, etc.), but certain errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, temperature is in °C or is at room temperature, and pressure is at or near atmospheric. There are many variations and combinations of reaction conditions such as component concentrations, temperatures, pressures, and other reaction ranges and conditions that can be used to optimize the product purity and yield obtained by the described process. Only reasonable...

Embodiment I

[1127] Example I: Didecyldimethylammonium saccharinate [DDA][Sac]

[1128] A reaction flask equipped with a stir bar and a thermometer was charged with 0.03 mol of didecyldimethylammonium bromide and 0.03 mol of saccharin sodium salt and 50 mL of water. The mixture was stirred vigorously at room temperature for one hour. Then 50 mL of chloroform was added. After phase separation, the chloroform phase is isolated (separated) and washed (multiple times) with fresh distilled water until all chloride ions are washed out (removed). Chloroform was distilled off (evaporated) and the residue (residue) was dried under vacuum at 60°C. High viscosity, liquid form of saccharinate was obtained in 95% yield. It is a hydrophobic liquid (fluid), lighter than water, and poorly soluble in cold and warm water. The thermal stability of this salt is listed in Table 2. Synthetic salts have been shown to have sweet taste and antimicrobial activity. Higher activity compared to the starting mate...

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PUM

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Abstract

Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

Description

[0001] Cross-references to related applications [0002] This application is a divisional application of the invention patent application titled "Multifunctional Ionic Liquid Composition" and application number 200680046195.7, which was submitted on June 6, 2008. This patent application claims the benefit of U.S. Provisional Application 60 / 764,850 filed on February 2, 2006, U.S. Provisional Application 60 / 724,604 filed on October 7, 2005, and U.S. Provisional Application 60 / 724,605 ​​filed on October 7, 2005 priority, the entire texts of these applications are each incorporated by reference into this specification. Technical field [0003] The subject matter disclosed herein relates generally to ionic liquids, and methods of preparing ionic liquid compositions containing active pharmaceutical ingredients, biological ingredients, nutritional ingredients, and energy ingredients. The subject matter disclosed herein also generally relates to methods of using compositions describe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N57/20A01N47/36A01N43/653A01N43/90A01N33/18A01N37/48A01N41/10A01N43/50A01N43/70A01N47/30A01N43/64A01N43/707A01N47/06A01N37/40A01N47/34A01N43/40A01N47/12A01N43/76A01N37/26A01N43/10A01N43/824A01N43/78A01N37/22A01N43/56A01N47/24A01N57/16A01P13/00A23L27/00
CPCA61K9/143A61K9/145A61K31/14A61K31/167A61K31/19A61K31/192A61K31/216A61K31/28A61K31/305A61K31/341A61K31/4174A61K31/43A61K31/44A61K31/451A61K31/465A61K31/496A61K31/519A61K31/5415A61K31/555A61K31/60A61K31/635A61K31/7036A61K45/06C07D239/34A61P17/16A61P23/00A61P3/02A61P31/00A61P31/04A61P31/12A61P43/00A61K2300/00A01N43/58A01N33/12A01N43/40
Inventor R·D·罗杰斯D·T·戴利R·P·斯沃特洛斯基W·L·霍夫J·H·戴维斯M·斯密格莱克J·珀耐克S·K·斯皮尓
Owner UNIVERSITY OF ALABAMA
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