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Preparation method of composite microgel with temperature, pH and magnetic field sensitivities

A microgel, sensitive technology, applied in the field of materials, to achieve the effect of simple operation, reasonable design, extensive research and application value

Inactive Publication Date: 2013-08-14
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no precipitation polymerization method has been used to directly encapsulate superparamagnetic ferric oxide particles in a poly(N-isopropylacrylamide-methacrylic acid)-based microgel network to form a simultaneous Related Chinese Patent Reports on Composite Microgels with Triple Sensitivity to Temperature, pH and Magnetic Field

Method used

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  • Preparation method of composite microgel with temperature, pH and magnetic field sensitivities
  • Preparation method of composite microgel with temperature, pH and magnetic field sensitivities
  • Preparation method of composite microgel with temperature, pH and magnetic field sensitivities

Examples

Experimental program
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Effect test

Embodiment 1

[0024] The structure of the composite microgel with triple sensitivity to temperature, pH and magnetic field and the process of swelling state / shrinking state adjusted by temperature / pH can be found in figure 1 , the detailed preparation steps are as follows: Dissolve 0.2mol ferric chloride, 0.1mol ferrous sulfate and 0.3mol thioglycolic acid in 100mL deionized water, raise the temperature to 60°C under magnetic stirring, add NaOH solution dropwise to adjust the reaction system If the pH is 7.5, a large number of black iron ferric oxide nanoparticles are obtained, and the temperature is raised to 80°C for aging for 30 minutes, then high-speed centrifugation, repeated washing, and vacuum drying to obtain dry powder of magnetic particles. Weigh 10 mg of magnetic particle dry powder and dissolve it in 100 mL of deionized water, add 20 mg of potassium persulfate, pass nitrogen gas for 30 min, raise the temperature to 70 °C under magnetic stirring and keep it for 10 min. Finally, 1...

Embodiment 2

[0027] The detailed preparation steps are as follows: Dissolve 0.3mol ferric chloride, 0.2mol ferrous sulfate and 0.5mol thioglycolic acid in 100mL deionized water, raise the temperature to 75°C under magnetic stirring, add NaOH solution dropwise to adjust the reaction system to When the pH is 8.0, a large amount of black iron ferric oxide nanoparticles are obtained, and the temperature is raised to 85°C for aging for 30 minutes, then centrifuged at a high speed, washed repeatedly, and dried in vacuum to obtain dry powder of magnetic particles. Weigh 15 mg of magnetic particle dry powder and dissolve it in 100 mL of deionized water, add 25 mg of potassium persulfate, pass nitrogen gas for 30 min, raise the temperature to 75 °C under magnetic stirring and keep it for 10 min. Finally, 15 mL of a mixed aqueous solution in which 150 mg of N-isopropylacrylamide, 15 mg of methacrylic acid, 15 mg of N, N-methylenebisacrylamide and 15 mg of sodium lauryl sulfate were dissolved was adde...

Embodiment 3

[0029] The detailed preparation steps are as follows: Dissolve 0.2mol ferric chloride, 0.2mol ferrous sulfate and 0.4mol thioglycolic acid in 100mL deionized water, raise the temperature to 70°C under magnetic stirring, add NaOH solution dropwise to adjust the reaction system to When the pH is 7.5, a large amount of black iron ferric oxide nanoparticles is obtained, and the temperature is raised to 80°C for aging for 30 minutes, then centrifuged at a high speed, washed repeatedly, and dried in vacuum to obtain dry powder of magnetic particles. Weigh 10 mg of magnetic particle dry powder and dissolve it in 10 mL of deionized water, add 20 mg of potassium persulfate, pass nitrogen gas for 30 min, raise the temperature to 75 °C under magnetic stirring and keep it for 10 min. Finally, 25 mL of a mixed aqueous solution in which 200 mg of N-isopropylacrylamide, 20 mg of methacrylic acid, 20 mg of N, N-methylenebisacrylamide and 20 mg of sodium lauryl sulfate were dissolved was added,...

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Abstract

The invention relates to a preparation method of a composite microgel with temperature, pH and magnetic field sensitivities. The method specifically comprises the following steps of: firstly, hydrolyzing a mixed divalent / trivalent inorganic iron salt in an alkaline aqueous solution by taking thioalcohol as a stabilizing agent and adopting a coprecipitation method to prepare nano ferroferric oxide particulates with superparamagnetism; and secondly, carrying out a sedimentation polymerization reaction under the combined action of an initiator, a crosslinking agent and a surfactant by taking N-isopropyl acrylamide as a temperature-sensitive monomer and methacrylic acid as a pH-sensitive monomer to prepare a magnetic nano ferroferric oxide coated poly(N-isopropyl acrylamide-methacrylic acid) composite microgel with the temperature, pH and magnetic field sensitivities. Compared with the prior art, the preparation method has the advantages of reasonable design, feasible process, simple operation, easily-controllable reaction and the like, and the prepared product has three sensitivities, and has wide application values in the biological medical material fields of medicament controlled release, chemical separation and the like.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a preparation method of a composite microgel with triple sensitivity to temperature, pH and magnetic field. Background technique [0002] Environmentally sensitive microgel, also known as smart microgel, refers to the ability to sense small changes or stimuli in the external environment (such as temperature, pH, ionic strength, biomolecules, light, electric field or magnetic field, etc.) A class of polymer gels that vary in structure and chemical properties. In view of its special environmental sensitivity, it has shown application prospects in many fields, especially in drug sustained release, protein separation and purification, active enzyme embedding, artificial muscles, biological probes and other functional materials. wide attention of foreign scholars. [0003] Among the many sensitive microgels, temperature- or pH-sensitive microgels have become one of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/54C08F220/06C08F222/38C08J3/24C08K5/07
Inventor 万锕俊桂日军李慧丽金辉
Owner SHANGHAI JIAO TONG UNIV
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