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Antitussive expectorant oral solution containing guaifenesin for children

A technology of guaiacol glycerin ether and oral solution, which is applied in the fields of ether/acetal active ingredients, drug delivery, respiratory diseases, etc., and can solve the problems of children's drug safety, effectiveness and good taste

Inactive Publication Date: 2013-07-31
湖北凤凰白云山药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no guaiacol ether drug specially designed for the characteristics of children’s medication on the market. It is difficult for the existing guaiacol glyceryl ether drug to meet the three basic requirements of safety, efficacy and good taste of children’s medication at the same time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Preparation of 70% sorbitol solution: stir the prescribed amount of sorbitol with an appropriate amount of purified water to dissolve, dilute to 350ml, and set aside.

[0044] Preparation of 80% sucrose solution: Stir the prescribed amount of sucrose with an appropriate amount of purified water to dissolve, dilute to 50ml, and set aside.

[0045] Weigh 20.0g of guaiacol glyceryl ether, 3.0g of pseudoephedrine hydrochloride, 9.0g of sodium chloride, 4.5g of citric acid, 8.5g of sodium citrate, add 100ml of purified water, stir (about 20 minutes) to dissolve, and then add 350ml of 70% sorbitol, 50ml of 80% sucrose, stir (10 minutes) evenly, let stand, add 1.0ml of banana essence, purified water to 1000ml, stir for 5 minutes, that is, canned.

Embodiment 2

[0047] Preparation of 70% sorbitol solution: stir the prescribed amount of sorbitol with an appropriate amount of purified water to dissolve, dilute to 350ml, and set aside.

[0048] Preparation of 80% sucrose solution: Stir the prescribed amount of sucrose with an appropriate amount of purified water to dissolve, dilute to 50ml, and set aside.

[0049] Weigh 18.0g of guaiacol glyceryl ether, 3.3.0g of pseudoephedrine hydrochloride, 8.0g of sodium chloride, 5.0g of citric acid, and 8.5g of sodium citrate, add 100ml of purified water, stir (about 20 minutes) to dissolve, and then Add polyethylene glycol 4000100ml, glycerin 400ml, 70% sorbitol 330ml, 80% sucrose 45ml, stir (10 minutes) evenly, let stand, add banana essence 1.0ml, purified water to 1000ml, stir for 5 minutes, that is, jar Pack.

Embodiment 3

[0051] Preparation of 70% sorbitol solution: stir the prescribed amount of sorbitol with an appropriate amount of purified water to dissolve, dilute to 350ml, and set aside.

[0052] Preparation of 80% sucrose solution: Stir the prescribed amount of sucrose with an appropriate amount of purified water to dissolve, dilute to 50ml, and set aside.

[0053]Weigh 22.0g of guaiacol glyceryl ether, 2.7g of pseudoephedrine hydrochloride, 11.0g of sodium chloride, 0.9g of sodium benzoate, 4.0g of citric acid, and 8.5g of sodium citrate, add 100ml of purified water, and stir (about 20 minutes) Make it dissolve, then add 400ml of glycerin, 350ml of 70% sorbitol, 55ml of 80% sucrose, stir (10 minutes) evenly, let stand, add 1.0ml of banana essence, purified water to 1000ml, stir for 5 minutes, that is, canned.

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PUM

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Abstract

The invention discloses medicine containing guaifenesin. The medicine containing the guaifenesin is safe and effective, and meets the taste of children better. Every 1000ml of the medicine comprises 18-22g of the guaifenesin, 2.7-3.3g of pseudoephedrine hydrochloride, 8.0-10.0g of sodium chloride, 4.0-5.0g of citric acid, 8.0-9.0g of sodium citrate, 0.9-1.1ml of fruit flavor essence, 220-260g of sorbitol, 36-44g of cane sugar, and the balance of water.

Description

technical field [0001] The invention relates to an oral solution for antitussive and expectorant for children, in particular to an oral solution for antitussive and expectorant for children containing guaiacol glycerin ether. Background technique [0002] Phlegm is the secretion of the human respiratory tract. It is pushed from the lungs to the respiratory tract through the movement of bronchial cilia and epithelial cilia. Finally, it is coughed out from the trachea through the normal cough reflex of a person. Normal people have very little sputum. A small amount of mucus secreted by moist airways. However, when people inhale harmful microorganisms such as irritating gas, dust, pathogenic bacteria, and viruses, inflammation of the upper respiratory tract may occur, or lung disease may occur, the secretion of the respiratory tract will increase, and the amount of sputum will increase, and the nature of the sputum will also change. There will be changes, and it can change fro...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K9/08A61P11/10A61P11/14A61K31/09
Inventor 程雪翔
Owner 湖北凤凰白云山药业有限公司
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