Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel production process of pancreatin

A production process and technology of pancreatin, applied in pancreatin, drug combination, digestive system, etc., can solve the problems of low content of pancreatic amylase and pancreatic lipase, etc.

Active Publication Date: 2013-07-24
CHONGQING AOLI BIOPHARM
View PDF3 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to the defects and demands in the above-mentioned fields, the present invention provides a method for preparing pancreatic enzyme, which can improve the yield of pancreatic enzyme product and solve the problem of low content of pancreatic amylase and pancreatic lipase in pancreatic enzyme, specifically as follows:

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel production process of pancreatin
  • Novel production process of pancreatin
  • Novel production process of pancreatin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Pancreatin production process

[0037] (1) The raw materials are porcine pancreas and porcine duodenum. Accurately weigh the raw materials that pass the quarantine, put them in the stainless steel tank in the pretreatment room, and let them thaw naturally for 10 hours;

[0038] (2) Flaking and refining: flaking the thawed raw materials with a pancreas planer, stirring and mixing the flaked raw materials with 1 times the amount (w / w) of low-concentration acetone solution; the low-concentration acetone is The acetone aqueous solution of 10% by volume is refined with a colloid mill;

[0039] (3) Activation and extraction: add 0.2% CaCl of raw material weight to the refining pulp 2 Activate as an activator, stir evenly, put into the extraction tank, temperature 5°C, extract for 20 hours;

[0040] (4) Separation and filtration: separate and filter the activated extract with a separator, and collect the pancreas milk filtrate;

[0041] (5) Precipitation: pump the pancre...

Embodiment 2

[0088] (1) The raw materials are porcine pancreas and porcine duodenum. Accurately weigh the raw materials that pass the quarantine, put them in the stainless steel tank in the pretreatment room, and let them thaw naturally for 5 hours;

[0089] (2) Planing and refining: planing the thawed raw materials with a pancreas planer, stirring and mixing the planed raw materials with 2 times the amount (w / w) of low-concentration acetone solution; the low-concentration acetone is The acetone aqueous solution of 30% by volume is refined with a colloidal mill;

[0090] (3) Activation and extraction: add 0.5% CaCl of raw material weight to the refining pulp 2 Activate as an activator, stir evenly, put into the extraction tank, temperature 10°C, extract for 15 hours;

[0091] (4) Separation and filtration: separate and filter the activated extract with a separator, and collect the pancreas milk filtrate;

[0092] (5) Precipitation: pump the pancreas milk filtrate into the sedimentation t...

Embodiment 3

[0107] (1) The raw materials are porcine pancreas and porcine duodenum. Accurately weigh the raw materials that pass the quarantine, put them in the stainless steel tank in the pretreatment room, and let them thaw naturally for 1 hour;

[0108] (2) Flaking and refining: flaking the thawed raw materials with a pancreas planer, stirring and mixing the flaked raw materials with 1.5 times (w / w) low-concentration acetone solution; the low-concentration acetone is The acetone aqueous solution of 20% by volume is refined with a colloid mill;

[0109] (3) Activation and extraction: add 0.4% CaCl of raw material weight to the refining pulp 2 Activate as an activator, stir evenly, put into the extraction tank, temperature 15°C, extract for 8 hours;

[0110] (4) Separation and filtration: separate and filter the activated extract with a separator, and collect the pancreas milk filtrate;

[0111] (5) Precipitation: pump the pancreas milk filtrate into the sedimentation tank, add acetone...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
percent by volumeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a novel production process of pancreatin, belonging to the technique of medicine manufacturing. The production process comprises the following steps of: unfreezing raw materials, polishing tablets, grinding into pulp, activating, separating, filtering, precipitating, squeezing, degreasing, palletizing, drying and crushing, wherein 0.2-0.5% CaCl2 is adopted as an activating agent in the step of activation, a 10-30% acetone solution is adopted for extraction, the extraction temperature is 5-15 DEG C, and the time is 8-20 hours. The productivity of pancreatin produced by using the production process is remarkably improved, and the ratios of pancreatic lipase and amylopsin are remarkably improved; and on such basis, the steps are further adjusted and optimized, so that the steps cooperate with one another so as to obtain a complete optimized production process, the pancreatin yield is about 14%, and the main indexes are that the trypsin content is about 3600 U / g, the amylopsin is about 100000 U / g, and the pancreatic lipase content is about 43000 U / g, and achieve the standard of exported pancreatin.

Description

technical field [0001] The invention belongs to the medicine manufacturing technology, in particular to a new production process of pancreatin. Background technique [0002] Pancreatin is a digestive drug recorded in the pharmacopoeias of various countries. It is a mixture of various enzymes extracted from animal pancreas. The main components are trypsin, pancreatic lipase and pancreatic amylase. Pancreatin is mainly used for indigestion, loss of appetite, and digestive disorders caused by liver and pancreatic diseases. It is also suitable for congenital pancreatic insufficiency, abdominal surgery, and pancreatic insufficiency caused by traumatic pancreatectomy. In addition, pancreatin contains a variety of active substances, which can be used as basic raw materials to extract a variety of biochemical drugs, such as pancreatic kininogen, elastase, asparaginase, chymotrypsin, carboxypeptidase, etc. [0003] At present, the production of pancreatin is mainly extracted from an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12N9/94A61P1/14
Inventor 冉崇荣朱占权陈曾兰乾友
Owner CHONGQING AOLI BIOPHARM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com