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Oxidation method of acetophenone

A technology of acetophenone and oxidant, applied in chemical instruments and methods, organic chemistry, molecular sieve catalysts, etc., can solve problems such as complex production process and harmful emissions, and achieve the effect of overcoming complex production process

Active Publication Date: 2013-07-17
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Compared with the traditional method, the method provided by the present invention overcomes the problems of complex traditional production process, equipment corrosion, and harmful emissions, and adopts heteroatom molecular sieve modified by soluble zinc salt as the oxidation active component, without adding any inhibitor to the raw material. agent or initiator for green synthesis process

Method used

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  • Oxidation method of acetophenone
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Examples

Experimental program
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Effect test

Embodiment 1

[0033] With acetophenone, hydrogen peroxide, solvent and catalyst (the mol ratio of zinc nitrate and titanium silicon molecular sieve 0.2: 1) according to acetophenone and hydrogen peroxide mol ratio is 1: 10, solvent acetonitrile and catalyst mass ratio are 20: 1. The mass ratio of acetophenone to catalyst is 10:1, and the reaction is carried out at a temperature of 50° C. and a pressure of 1.5 MPa. After 2 hours of reaction, the conversion rate of acetophenone was 83%; the selectivity of phenyl acetate was 66%.

Embodiment 2

[0035] Acetophenone, hydrogen peroxide, solvent and catalyst (the molar ratio of zinc phosphate and titanium silicon molecular sieve 1: 1) is 1: 6 according to the molar ratio of acetophenone and hydrogen peroxide, and the mass ratio of solvent acetone and catalyst is 50: 1. The mass ratio of acetophenone to catalyst is 20:1, and the reaction is carried out at a temperature of 60° C. and a pressure of 2.5 MPa. After 2 hours of reaction, the conversion rate of acetophenone was 59%; the selectivity of phenyl acetate was 68%.

Embodiment 3

[0037]With acetophenone, hydrogen peroxide, solvent and catalyst (the mol ratio of zinc sulfate and titanium silicon molecular sieve 0.1: 1) according to acetophenone and hydrogen peroxide mol ratio is 2: 11, solvent acetic acid and catalyst mass ratio are 60: 1. The mass ratio of acetophenone to catalyst is 1:1, and the reaction is carried out at a temperature of 100° C. and a pressure of 0.5 MPa. After 2 hours of reaction, the conversion rate of acetophenone was 56%; the selectivity of phenyl acetate was 70%.

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Abstract

The invention discloses an oxidation method of acetophenone. According to the method, under oxidation reaction conditions, acetophenone, an oxidant, a solvent and a catalyst are mixed and subjected to a contact reaction. The method is characterized in that the catalyst is a soluble zinc salt modified heteroatom molecular sieve.

Description

technical field [0001] The present invention relates to an oxidation method of acetophenone, and furthermore relates to a method for preparing phenyl acetate by catalytic oxidation of acetophenone. Background technique [0002] Phenyl acetate is a colorless liquid with a boiling point of 195.7°C, a relative density of 1.0780, a refractive index of 1.5033 and a flash point of 76°C. Miscible with ethanol, ether, chloroform and acetic acid, slightly soluble in water. A strong refraction, phenol smell. It is mainly used as a solvent and an intermediate in organic synthesis. Phenyl acetate can also be used to obtain oxyacetophenone through transposition reaction, which can be used to treat acute and chronic icteric hepatitis, cholecystitis and other diseases. [0003] At present, the industrial production of phenyl acetate is mainly obtained by the reaction of sodium phenate and acetic anhydride. One operation method is to add phenol into sodium hydroxide solution, stir and di...

Claims

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Application Information

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IPC IPC(8): C07C69/157C07C67/42B01J29/00B01J29/89
Inventor 林民史春风朱斌
Owner CHINA PETROLEUM & CHEM CORP
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