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Method for separating/gathering trace ciprofloxacin in food

A ciprofloxacin and food technology, applied in the field of environmental analysis, can solve the problems of large environmental pollution and time-consuming operation, achieve high extraction efficiency and reduce experimental costs

Inactive Publication Date: 2013-07-10
JIANGSU UNIV
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Problems solved by technology

The most commonly used method is solid-phase extraction, but solid-phase extraction uses organic solvents, which causes great environmental pollution, and the desorption process is very time-consuming.

Method used

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  • Method for separating/gathering trace ciprofloxacin in food
  • Method for separating/gathering trace ciprofloxacin in food
  • Method for separating/gathering trace ciprofloxacin in food

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Embodiment Construction

[0029] Phase-splitting salt selection

[0030] Selection of an appropriate phase separation is an important factor in aqueous two-phase systems. Functional polymer aqueous two-phase, using temperature-sensitive polymer EOPO as the extractant, requires a salt that can form an aqueous two-phase system with it and have a high extraction rate for the target antibiotic. Acidic salts ((NH 4 ) 2 SO 4 , NaH 2 PO 4 ), neutral salt (KCl, Na 2 SO 4 ) and alkaline salt (K 2 HPO 4 、K 2 CO 3 ) and EOPO form dihydrate relative to the influence of CIP extraction rate.

[0031] The volume of EOPO in the fixed upper phase was 3mL, and the concentrations of the six phase-splitting salts were all close to the saturation concentration (7mL) to form double water relative to the target, and the extraction experiments were carried out. The experimental results are as follows figure 1 shown. It can be seen from the figure that among the three different types of salts, the extraction rate ...

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Abstract

The invention relates to a method for separating / gathering trace ciprofloxacin in food, belonging to the field of environment analysis technologies. The method is a novel separation technology in which thermo-sensitive polymer EOPO (ethylene oxide and propylene oxide copolymer) and salt are mixed, the property that the affinity of a surface active agent and water is changed under a temperature change condition is utilized, and an aqueous two-phase system is formed with the combination of inorganic salt to perform extraction separation. The novel separation system has the advantage of aqueous two-phase extraction, and can realize secondary extraction due to the temperature separation property of the thermo-sensitive polymer, so that the extraction efficiency is higher than that of one-time extraction, and besides, the recovery of phase components enables the experiment cost to be reduced.

Description

technical field [0001] The invention belongs to the technical field of environmental analysis, and relates to a new method for separating / enriching trace amounts of ciprofloxacin (CIP) in food, especially referring to random copolymers of ethylene oxide and propylene oxide (EOPO) as Extractant, with inorganic salt dipotassium hydrogen phosphate (K 2 HPO 4 ) as a phase-separation salting-out agent to form an aqueous two-phase system (ATPS) to separate / enrich trace ciprofloxacin in food. Background technique [0002] Ciprofloxacin is a fully synthetic third-generation vanolone antibacterial drug, which has the characteristics of broad antibacterial spectrum, high intrinsic activity, strong penetrating power, and is not easy to produce cross-resistance with other antibacterial drugs, so it has been widely used clinically in various systemic infections. At the same time, it destroys the metabolism and proliferation of bacteria from the depth of the bacterial nucleus, can quic...

Claims

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Application Information

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IPC IPC(8): B01D11/04G01N30/89
Inventor 闫永胜陈波韩娟逯洋王赟
Owner JIANGSU UNIV
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