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Preparation method of traditional Chinese medicine composition for treating advanced non-small cell lung cancers

A technology of non-small cell lung cancer and composition, which is applied in the field of medicine, and can solve the problems of poor curative effect, low transfer rate of active ingredients of decocted medicines, and inconvenient administration.

Inactive Publication Date: 2014-03-26
杨凌无为制药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most lung cancers are treated with chemotherapy, which has large toxic and side effects and poor curative effect. The transfer rate of active ingredients of the decoction medicine is low, the curative effect is poor, and it is inconvenient to take.

Method used

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  • Preparation method of traditional Chinese medicine composition for treating advanced non-small cell lung cancers
  • Preparation method of traditional Chinese medicine composition for treating advanced non-small cell lung cancers
  • Preparation method of traditional Chinese medicine composition for treating advanced non-small cell lung cancers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Step 1. Take 900g of Scutellaria sinensis, 400g of Scutellaria barbata, 300g of astragalus, 120g of notoginseng, and 100g of bellflower;

[0104] Step 2. Remove impurities from the notoginseng described in step 1, wash, dry, pulverize, pass through a 100-mesh sieve, and use 6KGy cobalt 60 Standby after irradiation sterilization; remove impurities from Scutellaria barbata described in step 1, wash, and cut into sections according to the length of 10mm; remove impurities from Scutellaria sinensis, Radix Astragali and Platycodon grandiflorum described in step 1, wash, moisten thoroughly, Slice according to 2mm thickness;

[0105] Step 3. Combine the sectioned Scutellaria barbata in step 2 with the sliced ​​Aegypti chinensis, astragalus and bellflower, add 17kg of purified water and soak for 2 hours, then decoct at 95°C for 2 hours, and then use a 350-mesh filter cloth Filtrate while hot to obtain filtrate and medicinal residues;

[0106] Step 4: Add 17kg of purified wate...

Embodiment 2

[0111] Step 1. Take 900kg of Scutellaria sinensis, 400kg of Scutellaria barbata, 300kg of astragalus, 120kg of notoginseng, and 100kg of bellflower;

[0112] Step 2. Remove impurities from the notoginseng described in step 1, wash, dry, pulverize, pass through a 100-mesh sieve, and use 6KGy cobalt 60 Standby after irradiation sterilization; remove impurities from Scutellaria barbata described in step 1, wash, and cut into sections according to the length of 10mm; remove impurities from Scutellaria sinensis, Radix Astragali and Platycodon grandiflorum described in step 1, wash, moisten thoroughly, Slice according to 2mm thickness;

[0113] Step 3. Combine the sectioned Scutellaria barbata in step 2 with the sliced ​​scutellaria, astragalus and platycodon root, add 17000kg of purified water to soak for 2 hours, then decoct at 95°C for 2 hours, and then use a 350-mesh filter cloth Filtrate while hot to obtain filtrate and medicinal residues;

[0114] Step 4: Add 17000 kg of pur...

Embodiment 3

[0119] Step 1, get 900g of Sagerae sinensis, 400g of Scutellaria barbata, 300g of Radix Astragali, 120g of Panax notoginseng, 100g of Platycodon grandiflorum in parts by weight;

[0120] Step 2. Remove impurities from the notoginseng described in step 1, wash, dry, pulverize, pass through a 100-mesh sieve, and use 6KGy cobalt 60 Standby after irradiation sterilization; remove impurities from Scutellaria barbata described in step 1, wash, and cut into sections according to the length of 10mm; remove impurities from Scutellaria sinensis, Radix Astragali and Platycodon grandiflorum described in step 1, wash, moisten thoroughly, Slice according to 2mm thickness;

[0121] Step 3. Combine the sectioned Scutellaria barbata in step 2 with the sliced ​​Aegypti chinensis, astragalus and bellflower, add 17kg of purified water and soak for 2 hours, then decoct at 95°C for 2 hours, and then use a 350-mesh filter cloth Filtrate while hot to obtain filtrate and medicinal residues;

[0122]...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine composition for treating advanced non-small cell lung cancers. The method comprises the following steps of: 1. taking root of glaucescent fissistigma, barbated skullcup herb, radix astragali, sanqi and platycodon root; 2. removing impurities from sanqi and washing, drying, grinding, sieving and sterilizing sanqi, removing impurities from barbated skullcup herb and washing and cutting barbated skullcup herb into segments, removing impurities from glaucescent fissistigma, radix astragali and platycodon root and washing, moistening and slicing glaucescent fissistigma, radix astragali and platycodon root; 3. mixing barbated skullcup herb, glaucescent fissistigma, radix astragali and platycodon root and then adding water to soak the medicines, decocting the medicines and filtering the decoction; 4. adding water to the medicine dregs, decocting the medicine dregs, filtering the decoction, mixing the filtrate and concentrating the filtrate into thick paste under reduced pressure; 5. adding sanqi to the thick paste, mixing the medicines uniformly and then drying the mixture under reduced pressure, grinding the dried mixture and sieving the powder to obtain dry paste powder; and 6. capsulizing the dry paste powder to obtain a capsule, or adding dextrin and magnesium stearate to the dry paste powder, mixing the materials uniformly, granulating the mixture, drying the granules under reduced pressure, tabletting the dried granules and sugarcoating, thus obtaining a tablet. The preparation method has the advantages that the anticancer active ingredients in the traditional Chinese medicine are fully extracted and the transfer rates of the anticancer active ingredients are above 90%.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of a traditional Chinese medicine composition for treating advanced non-small cell lung cancer. Background technique [0002] The root cause of lung cancer is the lack of righteousness in the human body, feeling the evil poison, the evil poison invades the lungs, the air mechanism is blocked, the phlegm is turbid, the blood vessels are stagnant, and a lump is formed for a long time, which is the disease. Its pathogenesis mostly belongs to deficiency in origin and superficiality in superficiality, superficiality is mainly based on heat toxin, phlegm obstruction, and blood stasis, and deficiency in origin is mainly insufficiency of qi and blood. Chemotherapy is the main treatment for lung cancer at present, with large toxic and side effects and poor curative effect. The effective ingredients of the medicine decocted in water have a low transfer rat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61P11/00A61P35/00
Inventor 尹子郡
Owner 杨凌无为制药集团有限公司
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