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Medicine composition for treating biliary tract calculus, prepn. method and use thereof

A technology of biliary tract stones and compositions, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., which can solve problems such as difficulty in knowing the disease, undisclosed dosage of raw materials, usage of drugs, and different indications , to achieve the effect of feasible preparation process, stable quality and reasonable composition

Inactive Publication Date: 2009-01-21
SICHUAN XUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are related reports about "Gan Gall Stone Tablets", such as: Clinical Observation of 85 Cases of Hepatolithiasis Treated by Gan Gall Stone Tablets, Zhejiang Journal of Traditional Chinese Medicine (1999, 34 (7); Research on the Treatment of Cholelithiasis with Liver Gall Stone Tablets , Journal of Traditional Chinese Medicine, 1997, 38(3); Effects of Hepatolithiasis Tablets on Animal Inflammation and Bile Components, Journal of Traditional Chinese Medicine, 1998, 9(5); Litholysis, Antibacterial and Antispasmodic Effects of Hepatolithiasis in Vitro, Chinese Pharmacy 1998, September (2), which disclosed that the liver and gallbladder tablets were composed of ox gall water, fire salt, gallinaceous gold, citrus aurantii, Cyperus cyperi, woody, corydalis, coptis, Atractylodes macrocephala, evodia and other raw materials, but did not disclose The amount of raw materials and the usage of drugs, according to the theory of traditional Chinese medicine, different etiologies, pathogenesis, and different medicines in traditional Chinese medicine, without disclosing the amount of raw materials, it is difficult to know the disease it targets. Therefore, the usage and dosage of raw materials determine For the indications, the dosage of the same raw material is different, and the indications may be different

Method used

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  • Medicine composition for treating biliary tract calculus, prepn. method and use thereof
  • Medicine composition for treating biliary tract calculus, prepn. method and use thereof
  • Medicine composition for treating biliary tract calculus, prepn. method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Example 1 Preparation of the medicine of the present invention

[0026] 1. Prescription:

[0027] Beef Gallbladder Water 173g, Fire Nitrogen 115g, Chicken Neijin (fried) 133g, Citrus aurantium (fried with bran) 52g, Cyperus officinalis (made) 68g, Muxiang 34g, Corydalis (vinegar) 34g, Coptis chinensis 21g, Atractylodes (fried bran) ) 68g, Evodia (fried) 27g, galangal 41g, Hawthorn (fried coke) 68g, Jianqu 141g, green peel 34g;

[0028] Excipients: starch 4%, magnesium stearate 1%.

[0029] A total of 1,000 gallstone tablets were made from the above raw materials.

[0030] 2. Process and operation

[0031] (1) Mix the fried chicken Neijin, Jianqu and fire nitrate, pulverize according to the "Smashing Post Technical Safety Operation Method", pass through a 120-mesh sieve, and use the fine powder for use.

[0032] (2) Take green bark, wood incense, Atractylodes atractylodes, citrus aurantium, Cyperus officinalis, Evodia, galangal, coptis, Corydalis and hawthorn, put th...

Embodiment 2

[0046] The preparation of embodiment 2 medicine of the present invention

[0047] a, take by weighing the raw materials of the following weight proportions: ox gallbladder water 300g, fire salt 150g, chicken inner gold 200g, citrus aurantium 90g, Cyperus officinalis 100g, woodsy 50g, Corydalis fragrans 55g, Coptis chinensis 40g, Atractylodes Rhizoma 120g, Evodia 45g, Galangal 80g, Hawthorn 120g, Jianqu 200g, Qingpi 60g; (the raw materials can be processed or not processed)

[0048] b. Take chicken inner gold and fire nitrate and pulverize them into fine powder, for use;

[0049] c. Take Jianqu and smash;

[0050] d, the ox bile water is heated to boiling, filtered, and the filtrate is concentrated to obtain clear paste;

[0051] E, green bark, woody incense, Atractylodes japonica, Citrus aurantium, Cyperus officinalis, Evodia Fructus, galangal extract volatile oil by steam distillation, the volatile oil is packed with β-cyclodextrin, and the inclusions are dried and pulveriz...

Embodiment 3

[0053] The preparation of embodiment 3 medicine of the present invention

[0054] a, take by weighing the raw materials of the following weight proportions: ox gallbladder water 150g, fire nitrate 100g, chicken inner gold 100g, citrus aurantium 30g, Cyperus officinalis 30g, wood incense 20g, Corydalis chinensis 20g, Coptis chinensis 10g, Atractylodes Rhizoma 40g, Evodia 10g, Galangal 20g, Hawthorn 40g, Jianqu 120g, Qingpi 20g;

[0055] b. Take chicken inner gold and fire nitrate and pulverize them into fine powder, for use;

[0056] c. Take Jianqu heated water for extraction to obtain hot water extract;

[0057] d, the ox bile water is heated to boiling, filtered, and the filtrate is concentrated to obtain clear paste;

[0058] E, green bark, wood incense, Atractylodes japonica, Citrus aurantium, Cyperus officinalis, Evodia Fructus, galangal supercritical flow extraction volatile oil, volatile oil carries out inclusion with β-cyclodextrin, the inclusion matter is dried, pulv...

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Abstract

A Chinese medicine for treating cholelithiasis is prepared from 14 Chinese-medicinal materials including ox gall, cyprus tube, coptis root, haw, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating biliary calculi, which is prepared from traditional Chinese medicinal materials as raw materials, and belongs to the field of medicine. Background technique [0002] Among the medical metabolic diseases in the world, hepatolithiasis is increasing year by year, which is a serious threat to human health. The incidence of hepatolithiasis in the natural population was 10% in my country [1], 10% in the United States, 17.3% in Japan, and 18% in Germany [2], all showing an upward trend, becoming a common and frequently-occurring disease in various countries. In my country, bilirubin-based stones account for 40%, while bilirubin-based stones in rural areas account for 68%, which is a more serious threat to the health of rural people. [3] In 1971, Thistle and Schoenfield reported that CDCA was successful in dissolving cholesterol calculi, thus establishing oral lithotherapy as a part of modern ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61K35/413A61K35/38A61K33/00A61P1/16A61K35/57
Inventor 谢石方
Owner SICHUAN XUHUA PHARMA
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