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Piperine self-emulsifying soft capsule and preparation method thereof

A technology of self-emulsifying soft capsules and piperine, which is applied in the field of medicine to achieve the effects of improving curative effect, easy preparation, and convenient storage

Active Publication Date: 2013-07-03
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no public report of piperine self-emulsifying preparations at present. The self-emulsification technology adopted by the present invention can significantly improve the dissolution rate of piperine, more significantly improve the oral bioavailability of piperine, and then improve the curative effect of the drug, in order to be more suitable for patients. demand, providing a broader prospect for the rational development and utilization of piperine

Method used

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  • Piperine self-emulsifying soft capsule and preparation method thereof
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  • Piperine self-emulsifying soft capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of piperine self-emulsifying soft capsule

[0033] 1. The ingredients are shown in Table 1 below:

[0034] Table 1 Composition of piperine self-emulsifying soft capsules

[0035]

[0036] 2. Preparation method:

[0037] (1) Weigh 15g of piperine as shown in Table 1, dissolve piperine in 75g of co-surfactant diethylene glycol monoethyl ether (Transcutol P), mix well, then add 150g of ethyl oleate (oil phase), 270g of surfactant Tween 80, at a temperature of 55°C, ultrasonication for 30min, after complete dissolution, a transparent and uniform piperine self-emulsifying liquid was obtained;

[0038] (2) Weigh gelatin, glycerin and water as shown in Table 1, put them in a stainless steel jacketed pot, heat to melt the gelatin, add ethylparaben dissolved in ethanol, stir well, keep warm for 1-2 hours, measure the moisture to Set the standard, release the gelatin solution, filter it, and put it in an insulated bucket;

[0039] (3) The piperi...

Embodiment 2

[0041] Embodiment 2: the preparation of piperine self-emulsifying soft capsule

[0042] 1. The ingredients are shown in Table 2 below:

[0043] Table 2 Composition of piperine self-emulsifying soft capsules

[0044]

[0045]

[0046] 2. Preparation method:

[0047] (5) Weigh 15g of piperine as shown in Table 2, dissolve piperine in 70g of co-surfactant diethylene glycol monoethyl ether (Transcutol P), mix well, then add 175g of oleic acid (oil phase), 240g of surfactant Tween 80, at a temperature of 60°C, ultrasonication for 25 minutes, after complete dissolution, a transparent and uniform piperine self-emulsifying liquid was obtained;

[0048] (6) Weigh and weigh gelatin, glycerin and water as shown in Table 2, put them in a stainless steel interlayer pot, heat to melt the gelatin, add ethylparaben dissolved in ethanol, stir well, keep warm for 1-2h, and measure When the moisture reaches the specified standard, release the gelatin solution, filter it, and put it in a...

Embodiment 3

[0051] Embodiment 3: the preparation of piperine self-emulsifying soft capsule

[0052] 1. The ingredients are shown in Table 3 below:

[0053] Table 3 Composition of piperine self-emulsifying soft capsules

[0054]

[0055] Make 1000 capsules

[0056] Preparation method: the basic steps are the same as in Example 1, and the specific substances and amounts used are as shown in Table 3.

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Abstract

The invention discloses a piperine self-emulsifying soft capsule and a preparation method thereof. The preparation agent can improve the dissolution rate of piperine and bioavailability and further improves the curative effect. Piperine serving as the bioavailability reinforcer is adopted to prepare the self-emulsifying soft capsule, the bioavailability of other drugs can be improved in various ways, such as absorption, metabolism and the like, and great clinic significance is achieved on some medicines with excellent pharmacologic action, difficulty in absorption and easiness in metabolism. The piperine self-emulsifying soft capsule comprises piperine, an oil phase, a surfactant and a cosurfactant, of which the mass proportion is 1:(2.5-32.5):(15-35):(2.5-12.5). The preparation method comprises the following steps: dissolving a proper amount of piperine in the prescribed cosurfactant, uniformly mixing, then adding prescribed oil phase and surfactant, obtaining a transparent and homogeneous solution after complete dissolution, and pressing to obtain the soft capsule by adopting a conventional method.

Description

technical field [0001] The invention relates to a soft capsule and a preparation method thereof, in particular to a piperine self-emulsifying soft capsule and a preparation method thereof. The invention belongs to the technical field of medicine. Background technique [0002] Piperine belongs to cinnamon amide alkaloids and is the main chemical component of black pepper. It exists widely in nature, especially in Piperaceae. Antidepressant, antioxidative, drug metabolism promotion, etc., but its application as a bioavailability enhancer is more common. Piperine can increase the bioavailability of propranolol, cholophylline, curcumin, etc. in the body. As a bioavailability enhancer, piperine can be taken at the same time as the drug, or it can be used before or after the drug. [0003] Studies have shown that piperine can increase the absorption surface of small intestinal mucosa and promote drug absorption by changing membrane dynamics, membrane permeability and inducing t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/4525A61K47/14A61K47/26A61K47/10A61P35/00A61P25/08A61P25/24A61P39/06A61P3/00A61P43/00
Inventor 吴琳华邵兵崔超唐景玲
Owner HARBIN MEDICAL UNIVERSITY
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