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Traditional Chinese medicine for treating pathologic jaundice of neonate and preparation method thereof

A technology for pathological jaundice and neonates, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of retinal damage, expensive treatment, etc., achieves less toxic side effects, obvious clinical effects, easy to use effect of operation

Inactive Publication Date: 2013-06-26
张艳英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Western medicine believes that factors such as increased red blood cell destruction, low liver enzyme activity, and excretion defects of conjugated bilirubin are the pathological basis of pathological jaundice. According to the mechanism of jaundice, it can be divided into prehepatic, hepatocellular, and posthepatic. Western medicine uses intravenous injection of drugs combined with blue light therapy, which is not only expensive but also can cause rashes, diarrhea, retinal damage and other adverse consequences

Method used

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preparation example Construction

[0067] The present invention also provides a preparation method of the above-mentioned Chinese medicine, when the dosage form of the Chinese medicine is syrup, specifically:

[0068] The first step is to mix the components of the raw materials in proportion to obtain a mixture, add ethanol with an alcohol concentration of 70% to 80% to evenly moisten it, the mass ratio of the mixture to ethanol is 1:1 to 1:2, and place it in an airtight place for 12 hours ~18h, put it into the percolation tank, continue to add ethanol with an alcohol concentration of 70%~80% relative to the mass of the mixture 2~4 times, continue to soak for 6h~12h, percolate, the flow rate is 3~5ml per minute, collect the percolation Wet the liquid, filter, and concentrate the filtrate under reduced pressure at a pressure of -0.06 to -0.04 MPa and a temperature of 65°C to obtain an extract with a relative density of 1.15 to 1.20 at 65°C;

[0069] In the second step, take another sucrose and add water to decoc...

Embodiment 1

[0074] Embodiment 1 Syrup 1

[0075] Take 25g of chicken bone grass, 35g of green leaf gallbladder, 30g of Artemisia annua, 35g of turmeric, 30g of weeping pot grass, 35g of golden gentian, 45g of money grass, 50g of capillary, 60g of berberine, 50g of gardenia, 25g of Honglian, and Gentiana chinensis Mix 30g, Puhuang 40g, Centella asiatica 35g, Banzhilian 30g, Phellodendron 90g, Poria cocos 30g, Codonopsis 65g, saffron 50g, Chuanxiong 40g, Pulsatilla 60g and licorice 25g to obtain a mixture, add 1kg alcohol concentration to 80% Evenly wetted with ethanol, placed airtight for 18 hours, put into the percolation tank, continued to add 3kg of ethanol with an alcohol concentration of 80%, continued to soak for 12 hours, percolated, the flow rate was 4ml per minute, collected percolation liquid, filtered, and the filtrate was in Under the conditions of pressure -0.05MPa and temperature 65°C, concentrate under reduced pressure to obtain an extract with a relative density of 1.20 at ...

Embodiment 2

[0076] Embodiment 2 Syrup 2

[0077] Take 20g of chicken bone grass, 30g of green leaf gallbladder, 25g of Artemisia annua, 30g of turmeric, 25g of weeping pot grass, 30g of golden gentian, 40g of money grass, 45g of capillary, 55g of berberine, 45g of gardenia, 20g of Honglian, and Gentiana chinensis 25g, Puhuang 35g, Centella asiatica 30g, Scutellaria barbata 25g, Phellodendron 85g, Poria cocos 25g, Codonopsis 60g, Saffron 45g, Chuanxiong 35g, Pulsatilla 55g and Licorice 20g are mixed to obtain a mixture, add 1kg alcohol concentration to 80% Evenly wetted with ethanol, placed airtight for 18 hours, put into the percolation tank, continued to add 3kg of ethanol with an alcohol concentration of 80%, continued to soak for 12 hours, percolated, the flow rate was 4ml per minute, collected percolation liquid, filtered, and the filtrate was in Under the conditions of pressure -0.05MPa and temperature 65°C, concentrate under reduced pressure to obtain an extract with a relative dens...

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Abstract

The invention provides a traditional Chinese medicine for treating pathologic jaundice of neonate and a preparation method thereof. The raw material medicines of the traditional Chinese medicine comprise abrus cantoniensis hance, swertia mileensis, sweet wormwood, radix curcumae, sedum sarmentosum, conyza blinii, lysimachia christinae hance, oriental wormwood, rhizoma picrorhizae, jasmine, lagotisglauca, large-leaved gentian, pollen typhae, centella, sculellaria barbata, golden cypress, poria cocos, codonopsis pilosula, stigma croci, ligusticum wallichii, the root of Chinese pulsatilla and liquorice. Compared with treatment by western drugs, the traditional Chinese medicine has the advantages of remarkable clinical effect, small toxic and side effects, economy and easier operation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating neonatal pathological jaundice and a preparation method thereof. Background technique [0002] Neonatal jaundice is a common disease in the neonatal period. About 60% to 70% of full-term newborns have transient jaundice, and almost 100% of premature infants have jaundice. Neonatal jaundice is a common disease in the neonatal period. If it is not treated in time, bilirubin may be deposited in the brain to form bilirubin encephalopathy, which may leave serious sequelae of the nervous system and cause neonatal death in severe cases. [0003] Neonatal jaundice is divided into physiological jaundice and pathological jaundice. The former can transform into pathological jaundice under certain conditions. The incidence of neonatal pathological jaundice is relatively high, and some bilirubin encephalopathy can occur. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/08A61P1/16
Inventor 张艳英孙振芳
Owner 张艳英
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