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Stomach-regulating qi-coordinating decoction formula granule, and preparation method and detection method thereof

A technology of Tiaowei Chengqi Decoction and formula granules, which can be used in pharmaceutical formulations, preparation of test samples, medical preparations containing active ingredients, etc., and can solve problems such as poor quality control.

Active Publication Date: 2013-06-26
KANGMEI PHARMA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, the purpose of the present invention is to solve the problems that Tiaowei Chengqi Decoction formula granules existing in the prior art are not compatible with modern life, and the simple addition of each medicine flavor when taking single-flavor formula granules, and the quality is not very good In view of the lack of local control, a formula granule of Tiaowei Chengqi Decoction and its preparation method and detection method are provided. The formula granule of Tiaowei Chengqi Decoction fully exerts the requirements of compatibility of traditional Chinese medicines, is suitable for modern life, and has a simple preparation method. Detection method makes it safer to use

Method used

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  • Stomach-regulating qi-coordinating decoction formula granule, and preparation method and detection method thereof
  • Stomach-regulating qi-coordinating decoction formula granule, and preparation method and detection method thereof
  • Stomach-regulating qi-coordinating decoction formula granule, and preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Preparation of Example 1 Tiaowei Chengqi Decoction Formula Granules

[0093] 1. Source of medicinal materials

[0094] See Table 1 for sources and places of origin.

[0095] Table 1

[0096]

[0097] 2. Instruments and equipment

[0098] HWZ-5B-1 box-type microwave vacuum drying equipment, Tianshui Huayuan Pharmaceutical Equipment Technology Co., Ltd.; RE-5205 rotary evaporator, Shanghai Yarong Biochemical Instrument Factory.

[0099] 3. Preparation method

[0100] Take rhubarb and licorice and add water to decoct twice, filter, combine the filtrate, add Glauber’s salt to dissolve the filtrate after boiling, concentrate under reduced pressure at 70°C, and concentrate to a clear paste with a relative density of 1.05-1.10 (60°C), microwave drying, microwave power 5Kw, material temperature 50°C, running time 20min, drying to obtain dry paste granules, process flow chart see figure 1 .

[0101] The specific conditions are shown in Table 2 below:

[0102] Table 2...

Embodiment 2

[0118] Embodiment 2 Thin-layer chromatography identification embodiment 1 is A in process condition 2 B 2 C 2 time-made tune Weichengqi Decoction Formula Granules

[0119] 1. Identification of Rhubarb in Tiaowei Chengqi Decoction Formula Granules

[0120] 1.1 Medicinal materials and reagents

[0121] Rhubarb control medicinal material: batch number 120984-200301, purchased from China Institute for the Control of Pharmaceutical and Biological Products.

[0122] Chrysophanol reference substance: batch number 110796-201017, purchased from China Institute for the Control of Pharmaceutical and Biological Products.

[0123] Test product: 12011001, produced by Kangmei Pharmaceutical Co., Ltd. according to Example 1 under process conditions A 2 B 2 C 2 time method.

[0124] TLC plate: Silicone G plate, made by Kangmei Pharmaceutical Co., Ltd.

[0125] 1.2 Test steps

[0126] Preparation of Rhubarb test solution: Take 2.5g of Tiaowei Chengqi Decoction formula gr...

Embodiment 3

[0153] Embodiment 3 detects that embodiment 1 is A at process condition 2 B 2 C 2 Tiao Wei Cheng Qi Decoction Heavy metal content of square particles

[0154] The test items refer to the Chinese Pharmacopoeia 2010 edition, under the [check] item of Huanglian Shangqing Pills, take about 1g of Tiaowei Chengqi Decoction formula granules prepared according to the method in Example 1 (batch number 12011003, made by Kangmei Pharmaceutical Co., Ltd.) , accurately weighed, according to the residue on ignition inspection method (Appendix IXJ of the Chinese Pharmacopoeia 2010 Edition) to be completely ashed. Take the remaining residue and check according to the law (Appendix IX E Second Method of Chinese Pharmacopoeia 2010 Edition), the results show that the heavy metal content does not exceed 25ppm.

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Abstract

The invention provides a stomach-regulating qi-coordinating decoction formula granule, and a preparation method and a detection method thereof. The stomach-regulating qi-coordinating decoction formula granule is prepared from 2 parts of rheum officinale and 1 part of liquorice by the processes of adding water to decoct, adding 1.5 parts of mirabilite to dissolve after merging the filtrate, drying and pelletizing. The detection method comprises the following steps of identifying the stomach-regulating qi-coordinating decoction formula granule by thin layer chromatography; measuring the heavy metal content in the stomach-regulating qi-coordinating decoction formula granule by an ignition residue detection method; measuring the residue of organo-chlorine pesticide in the stomach-regulating qi-coordinating decoction formula granule by a pesticide residue determination method; measuring a finger-print of the stomach-regulating qi-coordinating decoction formula granule through high performance liquid chromatography; measuring the content of extractum of the stomach-regulating qi-coordinating decoction formula granule by a hot dipping process; and measuring the content of substances in the stomach-regulating qi-coordinating decoction formula granule by high performance liquid chromatography. The preparation method provided by the invention is simple; and the quality of the formula granule can be effectively controlled by the detection method.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine. It specifically relates to traditional Chinese medicine granules, a preparation method and a detection method thereof, in particular to Tiaowei Chengqi Decoction formula granules, a preparation method and a detection method thereof. Background technique [0002] Tiaowei Chengqi Decoction comes from Ming Fang Xian's "Miraculous Prescription", which is composed of rhubarb (five qian), licorice (three qian), and Glauber's salt (one and a half qian). Clothes. It has the function of slowing down heat knots, and it is mainly used for the treatment of gastrointestinal dryness and heat in Yangming disease. Difficulty in defecation, thirsty and upset, transpiration and heat, or fullness in the abdomen, or delirium, yellow tongue coating, slippery and rapid pulse; There are only three traditional Chinese medicines in the prescription, but the compatibility is appropriate: rhubarb, bitter and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/16A61P1/00A61P1/10A61P1/02A61P11/04G01N30/90G01N30/02G01N1/28G01N30/36G01N30/06A61K33/04
Inventor 韦冬菊许冬瑾马兴田向飞军吴小明陈有军
Owner KANGMEI PHARMA
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