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Modification process of surface bionic self-assembly multilayer film of artificial lens and artificial lens provided with surface bionic self-assembly multilayer film

An intraocular lens and multi-layer film technology, used in coatings, prostheses, medical science, etc., can solve the problems of high price of antibody drugs, affecting application value, toxic side effects, etc., to achieve good tissue and cell compatibility, avoid Toxic side effects, high biocompatibility effects

Inactive Publication Date: 2013-06-12
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned drug-loaded intraocular lens can inhibit the proliferation of lens epithelial cells relatively well, there are also some problems: while the loaded chemical drugs inhibit the proliferation of lens epithelial cells, they also inevitably affect corneal endothelial cells, iris, Other cells around the lens, such as ciliary body epithelial cells and retinal nerve cells, produce toxic and side effects; although loaded antibody drugs reduce the toxic and side effects on non-target cells, antibody drugs are expensive and easy to prepare, disinfect, store and Inactivation during transportation affects its practical application value

Method used

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  • Modification process of surface bionic self-assembly multilayer film of artificial lens and artificial lens provided with surface bionic self-assembly multilayer film
  • Modification process of surface bionic self-assembly multilayer film of artificial lens and artificial lens provided with surface bionic self-assembly multilayer film
  • Modification process of surface bionic self-assembly multilayer film of artificial lens and artificial lens provided with surface bionic self-assembly multilayer film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Positively charged surface activation of intraocular lens materials

[0028] Choice of hard and soft intraocular lenses, the materials of which are polymethylmethacrylate, polydimethylsiloxane PDMS silicone rubber and polyhydroxyethylmethacrylate hydrogel. Immersion to 1×10 -5 mol / L 3-aminopropyltriethoxysilane ethanol-water mixed solution, hydrolyzed for 2 hours, the surface of the intraocular lens material has positively charged amino groups, cleaned with ethanol-water mixed solution, and blown dry with nitrogen gas for later use.

Embodiment 2

[0029] Example 2: Negatively charged surface activation of intraocular lens materials

[0030]Choice of hard and soft intraocular lenses, the materials of which are polymethylmethacrylate, polydimethylsiloxane PDMS silicone rubber and polyhydroxyethylmethacrylate hydrogel. The intraocular lens was treated with surface plasma on a plasma generator by heating and volatilizing glacial acetic acid as a gas source. First, the flow rate is 20sccm, the inner pressure of the chamber is 0.3Torr, and the power is 100w, and the chamber is purged with Ar gas for 10min. Then put the intraocular lens into the chamber of the plasma generator, and use the acetic acid gas plasma to activate the intraocular lens. The conditions are: gas flow rate 20sccm, chamber pressure 0.3Torr, processing power 100w, processing time 60s.

Embodiment 3

[0031] Example 3: Preparation of surface biomimetic self-assembly (hyaluronic acid / chitosan) multilayer film modified intraocular lens

[0032] The artificial lens after surface activation is taken, and its material can be one of polymethyl methacrylate, polydimethylsiloxane PDMS silicone rubber and polyhydroxyethyl methacrylate hydrogel. In this example, a soft polydimethylsiloxane PDMS silicone rubber intraocular lens was taken. After surface activation by the scheme of Example 1, it was immersed in a 1 mg / mL negatively charged biomacromolecule hyaluronic acid solution, and statically adsorbed. After 10 minutes, take it out and wash it with phosphate buffer solution; then immerse the hyaluronic acid-adsorbed intraocular lens into 2 mg / mL positively charged biomacromolecule chitosan solution, let it stand for electrostatic adsorption for 10 minutes, take it out and wash it with phosphate buffer solution Cleaning; alternately assemble (hyaluronic acid / chitosan) for 1 t...

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Abstract

The invention relates to a modification process of a surface bionic self-assembly multilayer film of an artificial lens and the artificial lens provided with the surface bionic self-assembly multilayer film. The modification process of the surface bionic self-assembly multilayer film of the artificial lens comprises the following steps: the well cleaned artificial lens is provided with positive charge through surface pre-treatment, soaked into biomacromolecule polyelectrolyte solution provided with negative charge, placed still for electrostatic adsorption for a period of time, taken out and cleaned; then the artificial lens is soaked into biomacromolecule polyelectrolyte solution provided with positive charge, placed still for electrostatic adsorption for a period of time, taken out and cleaned; the alternative electrostatic assembly process is repeated for several times, at last the artificial lens is dried at room temperature, and the artificial lens modified by the surface bionic self-assembly multilayer film is obtained. The modification process of the surface bionic self-assembly multilayer film of the artificial lens and the artificial lens provided with the surface bionic self-assembly multilayer film have the advantages that a bionic modification layer formed by an artificial lens surface bionic lens envelope is obtained through a simple, convenient and rapid bionic method, adhesion and breeding of impedance lens epithelial cells are achieved, toxic and side effects on non-target cells existing in the application of a drug coating artificial lens are avoided, and the obtained artificial lens is high in biological compatibility.

Description

technical field [0001] The invention belongs to the field of medical implant materials and device surface modification, in particular to a modification process of a bionic self-assembled multilayer film on the surface of an artificial lens and an artificial lens with a surface bionic self-assembled multilayer film. Background technique [0002] Cataract A blinding eye disease. At present, the surgical treatment of cataract mainly adopts phacoemulsification combined with intraocular lens implantation. However, foreign body reactions are common in intraocular lenses prepared from materials such as polymethylmethacrylate, polyhydroxyethylmethacrylate hydrogel, and silicone rubber, which are widely used at present. After intraocular lens implantation, the lens capsule becomes opacified again, also known as after-onset cataract, which is the main complication that seriously affects the visual recovery of patients after intraocular lens implantation. In general, the incidence ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/04C08L33/12C08L83/04C08L33/14A61L27/40
Inventor 林全愧黄小洁南开辉张斌俊陈浩
Owner WENZHOU MEDICAL UNIV
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