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Calcium sulfate spherical particle alveolar bone repair material and preparation method and application thereof

A technology of spherical particles and repair materials, applied in medical science, prosthesis, etc., can solve the problems of biological activity and physical and chemical properties decline, coarse particle size of reinforcement, difficult to degrade, etc., achieve complete degradation and degradation cycle, and simple preparation process. , excellent biological activity

Active Publication Date: 2013-04-24
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These studies have achieved certain results, but there are still some problems: (1) Pure mechanical mixing cannot significantly reduce the degradation rate of calcium sulfate composites, which is due to the presence of reinforcement particles in the composites prepared by the traditional external addition method. (2) The high-temperature solid-state phase transition reaction is used for the composite material, but the calcium sulfate composite material after high-temperature sintering is difficult to degrade or does not degrade, and the biological properties of the material The decline in activity and physical and chemical properties also limits its development in the direction of controllable slow-release carriers; (3) The surface of calcium sulfate is modified by polymer film coating technology, so that calcium sulfate cannot release calcium ions in the early stage, and local high calcium The environment has great significance for bone repair materials

Method used

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  • Calcium sulfate spherical particle alveolar bone repair material and preparation method and application thereof
  • Calcium sulfate spherical particle alveolar bone repair material and preparation method and application thereof
  • Calcium sulfate spherical particle alveolar bone repair material and preparation method and application thereof

Examples

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Embodiment 1

[0034] Example 1: Preparation method of calcium sulfate spherical particles alveolar bone repair material, the specific operation is as follows:

[0035] (1) Preparation of α-type calcium sulfate hemihydrate powder: Weigh 0.45g of ground aluminum sulfate octahydrate powder, put it in a 250ml beaker, weigh 31g calcium sulfate dihydrate powder with weighing paper, and add 0.45 g In the beaker where the aluminum sulfate is located, stir with a glass rod until uniformly mixed. Place the beaker in a closed autoclave with a steam pressure of 0.14 MPa and a temperature of 127°C for 8 hours at a constant temperature and pressure, and then take out the drum placed at 80°C Dry for 12 hours in an air drying oven, grind and encapsulate to obtain α-type calcium sulfate hemihydrate powder, such as figure 1 ;

[0036] (2) Prepare spherical calcium sulfate particles with a particle size of 0.5~2.0mm: weigh 2g of α-type calcium sulfate hemihydrate powder, shake it in a vibrating screen, and spray d...

Embodiment 2

[0039] Example 2: Preparation method of calcium sulfate spherical granule alveolar bone repair material, the specific operation is as follows:

[0040] (1) Preparation of α-type calcium sulfate hemihydrate powder: Weigh 0.45g of ground aluminum sulfate octahydrate powder, put it in a 250ml beaker, weigh 31g calcium sulfate dihydrate powder with weighing paper, and add 0.45 g In the beaker where the aluminum sulfate is located, stir with a glass rod until uniformly mixed. Place the above beaker in a closed autoclave with a steam pressure of 0.15 MPa and a temperature of 125°C for 6 hours at a constant temperature and pressure, and then take out the drum placed at 80°C Dry in an air drying oven for 12 hours, grind and encapsulate to obtain α-type calcium sulfate hemihydrate powder;

[0041] (2) Preparation of spherical calcium sulfate particles with a particle size of 0.5~2.0mm: Weigh 2g of α-type calcium sulfate hemihydrate powder, shake it in a vibrating screen, and spray the ball...

Embodiment 3

[0044] Embodiment 3: The preparation method of calcium sulfate spherical particles alveolar bone repair material, the specific operation is as follows:

[0045] (1) Preparation of α-type calcium sulfate hemihydrate powder: weigh 0.08g of ground aluminum sulfate powder, put it in a 250ml beaker, weigh 31g of calcium sulfate dihydrate powder with weighing paper, and put 0.08g of aluminum sulfate in In the beaker, stir with a glass rod until uniformly mixed. Place the beaker in a closed high-pressure reactor with a steam pressure of 0.14MPa and a temperature of 126°C for 4 hours at a constant temperature and pressure, and then take it out and place it in a blast drying oven at 80°C. Dry for 12 hours, grind and encapsulate to obtain α-type calcium sulfate hemihydrate powder;

[0046] (2) Preparation of spherical calcium sulfate particles with a particle size of 0.5~2.0mm: Weigh 2g of α-type calcium sulfate hemihydrate powder, shake it in a vibrating screen, and spray the balls with a ...

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Abstract

The invention relates to a calcium sulfate spherical particle alveolar bone repair material and a preparation method thereof. The calcium sulfate spherical particle alveolar bone repair material is mainly used for alveolar bone defect repair and also can be used for other bone defect repair, and belongs to the field of biomedical material. The calcium sulfate spherical particle alveolar bone repair material is characterized in that active ingredients are prepared from the following raw materials: (a) calcium sulfate, (b) molding liquid, and (c) surface modification liquid; and the size of the spherical particle is 0.5-2.0mm. The calcium sulfate is alpha type hemihydrate calcium sulfate powder. The surface modification liquid is soluble silicate aqueous solution. The calcium sulfate spherical particle alveolar bone repair material and the preparation method thereof have the following advantages: the provided calcium sulfate spherical particle alveolar bone repair material has the advantages of being excellent in biological activity, being capable of completely being degraded for a controllable period, and the like; good space can be provided for the growth of bone cells through big holes with the diameters of 183-732 microns produced by piling of spherical calcium sulfate particles in specific sizes; and the material is simple in preparation technology, short in preparation period and low in cost.

Description

Technical field [0001] The invention relates to a calcium sulfate spherical particle alveolar bone repairing material and a preparation method and application thereof. The material is mainly used for the repair of alveolar bone defects and can also be used for other bone defect repairs, belonging to the field of biomedical materials. Background technique [0002] Maxillofacial alveolar bone defects caused by inflammation, trauma, tumor or congenital malformations are very common. Since the alveolar bone is located in the middle and lower parts of the face, it is an important part of the chewing organs, language organs, and respiratory organs. It is also one of the important supporting structures of the face. It affects the beauty of the face. Therefore, the alveolar bone defect is physically and psychologically Will cause serious effects on patients. At present, the repair and reconstruction of bone defects is the difficulty and focus of research in orthopedics, maxillofacial su...

Claims

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Application Information

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IPC IPC(8): A61L27/02
Inventor 陈庆华伍小沛黄明华颜廷亭
Owner KUNMING UNIV OF SCI & TECH
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