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Perhexiline lipidosome injection

A technology of Guanxinning fat and injection, which is applied in the field of medicine to achieve the effects of improving curative effect, improving bioavailability, and increasing retention time

Inactive Publication Date: 2015-01-07
海南路易丹尼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, the challenge in preparing liposomes lies in selecting the appropriate liposome composition and formulation

Method used

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  • Perhexiline lipidosome injection
  • Perhexiline lipidosome injection
  • Perhexiline lipidosome injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Guanxinning liposome injection

[0035] prescription

[0036]

[0037]

[0038] making process

[0039] (1) Weigh 20,000g of Salvia miltiorrhiza and 20,000g of Chuanxiong, add 400L of water to decoct three times, the first time for 2 hours, the second and third time for 1.5 hours each, combine the decoction, filter, concentrate the filtrate to 2L, and use ethanol precipitation treatment The second time, the alcohol content reached 75% for the first time, and 85% for the second time. After adding ethanol each time, they were kept in cold storage, filtered, and the filtrate was combined, concentrated to about 1L, diluted to 4L with water for injection, and diluted with dilute Adjust the pH value to 3.2 with hydrochloric acid, refrigerate, filter, adjust the pH value to 6.8 with 10% sodium hydroxide solution, concentrate to 1L, refrigerate, filter, adjust the pH value to 6.8, and boil for 30 minutes to obtain a concentrated medicinal solution ;

[004...

Embodiment 2

[0044] Embodiment 2 Guanxinning liposome injection

[0045] prescription

[0046]

[0047] making process

[0048] (1) Weigh 4000g of Salvia miltiorrhiza and 4000g of Chuanxiong, add 80L of water and decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, concentrate the filtrate to 0.5L, and precipitate with ethanol Treat twice, the first time to make the alcohol content reach 75%, the second time to 85%, after adding ethanol each time, keep it in cold storage, filter, combine the filtrate, concentrate to about 0.2L, and dilute to 0.4L with water for injection , adjust the pH value to 3.2 with dilute hydrochloric acid, refrigerate, filter, adjust the pH value to 6.8 with 10% sodium hydroxide solution, concentrate to 0.2L, refrigerate, filter, then adjust the pH value to 6.8, boil for 30 minutes, and prepare Concentrated liquid medicine;

[0049] (2) Weigh 200g of phosphatidylglycerol, 100g of cholestero...

Embodiment 3

[0053] Embodiment 3 Guanxinning liposome injection

[0054] prescription

[0055]

[0056] making process

[0057] (1) Weigh 4000g of Salvia miltiorrhiza and 4000g of Chuanxiong, add 80L of water and decoct three times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoction, filter, concentrate the filtrate to 0.5L, and precipitate with ethanol Treat twice, the first time to make the alcohol content reach 75%, the second time to 85%, after adding ethanol each time, keep it in cold storage, filter, combine the filtrate, concentrate to about 0.2L, and dilute to 0.4L with water for injection , adjust the pH value to 3.2 with dilute hydrochloric acid, refrigerate, filter, adjust the pH value to 6.8 with 10% sodium hydroxide solution, concentrate to 0.2L, refrigerate, filter, then adjust the pH value to 6.8, boil for 30 minutes, and prepare Concentrated liquid medicine;

[0058] (2) Weigh 100g of phosphatidylglycerol, 200g of choleste...

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Abstract

The invention provides perhexiline lipidosome injection which is mainly prepared from salvia miltiorrhiza, ligusticum wallichii, phosphatidyl glycerol, cholesterol, tween 80, edetate disodium and sodium hydrogen sulfite. Compared with the existing preparation, the injection largely improves the stability and the bioavailability of the preparation, smoothly releases drugs, improves the preparation product quality, reduces the poison and side effects, and has more remarkable curative effect.

Description

technical field [0001] The invention relates to a novel injection preparation of Guanxinning, in particular to a liposome injection of Guanxinning and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Guanxinning is a traditional Chinese medicine preparation commonly used in recent years for promoting blood circulation and removing blood stasis. Guanxinning injection is composed of two traditional Chinese medicines, Danshen and Chuanxiong. The chemical components in Chuanxiong mainly include alkaloids such as ligustrazine and phenolic substances such as ferulic acid, chrysophanol and ligustrazine. The pharmacological effects of Rhizoma Chuanxiong are mainly through the antagonism of calcium and scavenging free radicals. It has obvious protective and improvement effects on the damage of ischemic tissues and organs. 2 / PGI 2 have antithrombotic effects. [0003] Salvianolic acid has a protective effect on cerebral isc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K47/28A61K9/127A61P9/10A61P11/00A61P1/08A61P25/28A61P9/04A61P9/00A61P31/12A61P3/10A61P25/02A61P13/12A61K36/236
Inventor 王平
Owner 海南路易丹尼生物科技有限公司
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