Absorbable medical dressing and preparation method thereof

Abstract

The invention provides an absorbable medical dressing. The absorbable medical dressing comprises an elastic backing and a polymeric matrix layer arranged on the backing, wherein the backing comprises at least one of polyurethane, hyaluronic acid, hyaluronate, absorbable aliphatic polyester and polyhydroxy butyric acid; the polymeric matrix layer comprises at least one of polyacrylic acid, alginic acid, chitosan, water-soluble polyamide, chitosan derivative, polylysine and cellulose derivative; a medicine layer is arranged on the polymeric matrix layer; and the medicine layer comprises at least one of collagen, fibrinogen, growth factor and antibiotic. A preparation method of the absorbable medical dressing comprises the following steps: (1) preparing a polymeric matrix aqueous solution; (2) injecting the prepared polymeric matrix aqueous solution into a mould; (3) freezing the polymeric matrix aqueous solution in the mould; (4) lyophilizing the frozen polymeric matrix aqueous solution; and (5) postprocessing polymeric matrix sponge to prepare the absorbable medical dressing.

Description

technical field [0001] The invention relates to a dressing and a preparation method thereof, in particular to an absorbable medical dressing and a preparation method thereof. Background technique [0002] Trauma is a serious problem that endangers human health. According to the World Health Organization Trauma Treatment Guidelines, 16,000 people worldwide die from trauma every day, and medical expenses due to trauma are as high as 16% of all global medical expenditures, and 1 / 2 of the trauma patients 3 is death due to blood loss and multiple organ failure related to blood loss. If the bleeding can be stopped in time and effectively, it is very important to save the life of the wounded, stabilize the injury, and create conditions for follow-up treatment. Dressing, as a hemostatic material, refers to a protective covering on the wound, which can help control bleeding, prevent infection and absorb secretions. Hemostatic dressings are of great significance for timely hemostasis...

AI Technical Summary

Problems solved by technology

[0003] Traditional hemostatic dressings generally improve the hemostatic performance of the dressing by adding bioactive molecules, such as thrombin and fibrin, but the manufacturing cost of such dressings is high, and it is difficult to maintain the activity of such bioactive molecules

The existing hemostatic dressing is a chitosan derivative modified by polyacrylic acid. The porous sponge with chitosan and gelatin as the main components has poor wet stability and is easy to dissolve in wounds with a lot of blood oozing, so it cannot exert its coagulation performance